A Proprioceptive Janus Fiber with Controllable Multistage Segments for Bionic Soft Robots.

Smart fibers capable of integrating the multifunctionality of actuation and self-sensation into a single proprioceptive device have significant applications in soft robots and biomedicine. Especially, the achievement of self-sensing the movement patterns of different actuating segments in one fiber is still a great challenge. Herein, in this study, a fiber with the controllable Janus architecture is successfully proposed via an artful centrifugation-driven hierarchical gradient self-assembly strategy, which couples two functional components of piezoresistive carbon nanotubes and magnetic NdFeB nanoparticles into the upper and lower layers of this flexible fibrous framework with the porous sponge structure partially, respectively.

Dendritic cell mineralocorticoid receptor controls blood pressure by regulating T helper 17 differentiation: role of the Plcβ1/4-Stat5-NF-κB pathway.

Background And Aims: Dendritic cells (DCs) are closely related to blood pressure (BP) regulation. Mineralocorticoid receptor (MR) is an important drug target for antihypertensive treatment. However, the role of DC MR in the pathogenesis of hypertension has not been fully elucidated.

Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats.

Approximately 50% of patients with chronic neuropathic pain experience cognitive impairment, which negatively impacts their quality of life. The cannabinoid type 2 receptor (CB2R) may be involved in hippocampal cognitive processes. However, its role in chronic neuropathic pain-induced cognitive impairment remains elusive.

Tailoring Atomic Ordering Uniformity Enables Selectively Leached Nanoporous Pd-Ni-P Metallic Glass for Enhanced Glucose Sensing.

Constructing nanostructures, such as nanopores, within metallic glasses (MGs) holds great promise for further unlocking their electrochemical capabilities. However, the MGs typically exhibit intrinsic atomic-scale isotropy, posing a significant challenge in directly fabricating anisotropic nanostructures using conventional chemical synthesis. Herein a selective leaching approach, which focuses on tailoring the uniformity of atomic ordering, is introduced to achieve pore-engineered Pd-Ni-P MG.

Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1.

Brassinosteroids (BRs) are steroidal phytohormones indispensable for plant growth, development, and responses to environmental stresses. The export of bioactive BRs to the apoplast is essential for BR signaling initiation, which requires binding of a BR molecule to the extracellular domains of the plasma membrane-localized receptor complex. We have previously shown that the Arabidopsis thaliana ATP-binding cassette (ABC) transporter ABCB19 functions as a BR exporter and, together with its close homolog ABCB1, positively regulates BR signaling.

Effect of machining method and margin design on the accuracy and margin quality of monolithic zirconia crowns.

Statement Of Problem: The machining accuracy and marginal integrity of monolithic zirconia crowns with minimal invasive preparations may impact the long-term survival rate of tooth and periodontal health, but studies on the effect of machining method are lacking.

Purpose: The purpose of this in vitro study was to digitally evaluate the machining accuracy and margin quality of monolithic zirconia crowns fabricated using gel deposition and conventional soft milling processes by comparing 2 different margin types.

Material And Methods: A total of 40 monolithic zirconia crowns were produced using gel deposition (Self-glazed Zirconia Group, SGG, n=20) and soft milling (Milled Zirconia Group, MG, n=20).

Neutrophil pyroptosis regulates corneal wound healing and post-injury neovascularisation.

Rationale: The cornea is a unique structure that maintains its clarity by remaining avascular. Corneal injuries can lead to neovascularisation (CNV) and fibrosis and are the third most common cause of blindness worldwide.

Objective: Corneal injuries induce an immune cell infiltration to initiate reparative processes.

SynNotch-Programmed Macrophages for Cancerous Cell Detection and Sensing.

Synthetic Notch (synNotch) receptors have enabled mammalian cells to sense extracellular ligands and respond by activating user-prescribed transcriptional programs. Based on the synNotch system, we describe a cell-based in vivo sensor for cancerous cell detection. We attempted to engineer synNotch-programmed macrophages to sense cancer cells via urinary analysis of human chorionic gonadotropin (HCGB5).

Characteristics and genesis of high-quality metasilicate mineral water in Liaocheng City, Shandong Province.

Drinking natural mineral water often contains minerals and trace elements essential for human beings, such as strontium and silicon. As people's quality of life improves, so do their requirements for drinking water. Therefore, it is crucial to identify and develop high-quality groundwater that is rich in metasilicate and other minerals.

PD-1CD8 T Cell-Mediated Hepatocyte Pyroptosis Promotes Progression of Murine Autoimmune Liver Disease.

The specific mechanisms underlying effector pathways in autoimmune liver disease remain enigmatic and therefore constructing appropriate murine models to investigate disease pathogenesis becomes critical. A spontaneous severe murine model of autoimmune liver disease has been previously established in dnTGFβRII Aire mice, exhibiting disease phenotypes that resemble both human primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). The data suggests that auto-reactive liver-specific CD8 T cells are the primary pathogenic cells in liver injury.

A novel chimeric endolysin Cly2v shows potential in treating streptococci-induced bovine mastitis and systemic infections.

species are important pathogens implicated in bovine mastitis, causing considerable economic losses within the global dairy industry. With the development of multidrug-resistant bacteria, it is crucial to develop novel antibiotic alternatives. Here, we constructed a novel chimeric endolysin, Cly2v, which comprises the Ply2741 CHAP domain (1-155aa) and the PlyV12 CBD domain (146-314aa).

Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway.

Background: The gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of a range of health issues including inflammatory and autoimmune conditions, metabolic disorders, cardiovascular problems, and psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence and presentation between genders. The present study aimed to evaluate whether the composition of gut microbiota is associated with sex-specific differences and to elucidate the mechanism.

Microbial community assembly patterns at the species level in different parts of the medium temperature Daqu during fermentation.

Medium-temperature Daqu (MT-Daqu) serves as a crucial saccharifying and fermentation agent in the production of strong-flavor Baijiu. Due to the spatial heterogeneity of solid fermentation, significant differences occurred in the fermentation state and appearance features in different parts of Daqu during fermentation. Currently, the understanding of the underlying mechanism behind this phenomenon remains limited.

Hybrid Homodimeric Prodrug Nanoassemblies for Low-Toxicity and Synergistic Chemophotodynamic Therapy of Melanoma.

Synergistically active nanoparticles hold great promise for facilitating multimodal cancer therapy. However, strategies for their feasible manufacture and optimizing their formulations remain lacking. Herein, we developed hybrid homodimeric prodrug nanotherapeutics with tumor-restricted drug activation and chemophotodynamic pharmacology by leveraging the supramolecular nanoassembly of small molecules.

Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on Holstein bull testis after sexual maturity.

Spermatogenesis is an extremely sophisticated and complex process and is regulated not only by a large number of genes, but also by a large number of epigenetic factors. Although existing studies have demonstrated that circRNAs plays an important regulatory role in spermatogenesis, there is still insufficient information to properly understand the regulatory role and mechanism of circRNA action. We addressed this issue by examining the testes of two Holstein bull developmental stages; three 8-week-olds (young bull, YB) and three 80-week-olds (adult bull, AB), randomly selected from the same breeding stock.

Photo-Induced Radical Generation of Supramolecular Gel with Sign-Inverted and White-Light Circularly Polarized Luminescence.

The realization of persistent luminescence and in particular circularly polarized luminescence (CPL) of organic radicals remains a challenge due to their sensitivity to oxygen at ambient conditions and elusive excited state chirality control. Here, it is reported that UV-irradiation on a supramolecular gel from a chiral triarylamine derivative, TPA-Ala, led to the formation of luminescent radicals with bright CPL. TPA-Ala can form an organogel in chloroform with blue emission and supramolecular chirality as demonstrated by both CD and CPL signals.

FLASH radiotherapy using high-energy X-rays: Current status of PARTER platform in FLASH research.

Purpose: Recent studies indicated that ultrahigh dose rate (FLASH) radiation can reduce damage to normal tissue while maintaining anti-tumour activity compared to conventional dose rate (CONV) radiation. This paper provides a comprehensive description of the current status of the Platform for Advanced Radiotherapy Research (PARTER), which serves as the first experimental FLASH platform utilizing megavoltage X-rays and has facilitated numerous experiments.

Methods And Materials: PARTER was established in 2019 based on a superconducting linac to support experimental FLASH studies using megavoltage X-rays.

Upregulation of Nav1.6 expression in the ventral posterolateral nucleus of thalamus contributes to hyperalgesia in a model of Parkinson's disease.

Pain is the most common non-motor manifestation of Parkinson's disease (PD), affecting the quality of life for patients. Nav1.6 is the most abundant subtype of voltage-gated sodium channels (VGSCs) in the brain of adult mammals.

Efficacy and safety of ZX-7101A, an inhibitor of influenza cap-dependent endonuclease, in adults with uncomplicated influenza: a randomized, double-blind, placebo-controlled phase 2/3 trial.

Objectives: To evaluate the efficacy and safety of ZX-7101A: an inhibitor of influenza viral cap-dependent endonuclease, in adults with uncomplicated influenza and explore treatment-emergent resistance.

Methods: We conducted a randomized, double-blind, placebo-controlled, adaptive-design phase 2 and phase 3 studies (ZX-7101A-202) in adults with uncomplicated influenza. Eligible patients were randomized 1:1:1 to receive a single dose of 40 or 80 mg ZX-7101A or placebo, stratified by body weight and baseline composite symptom score.