Lignocellulose nanofiber-enhanced hydrogel electrolytes with lignin-Al in metal-based neutral deep eutectic solvent for flexible supercapacitors.

The mechanical flexibility and high conductivity of hydrogel electrolytes are crucial for their application in supercapacitors. In this study, we developed hydrogel electrolyte based on lignocellulose nanofibers (LCNFs) through nanofibrillation and self-catalytic gelation in a glycerinum/choline chloride/aluminum chloride hexahydrate (Gly/ChCl/AlCl·6HO) metal-based neutral deep eutectic solvent (DES) system. The lignin-Al self-catalytic mechanism offered an eco-friendly and sustainable method for synthesizing hydrogel electrolytes, while enhancing their ionic conductivity.

Individualized treatment recommendations for patients with locally advanced head and neck squamous cell carcinoma utilizing deep learning.

Background: The conventional treatment for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is surgery; however, the efficacy of definitive chemoradiotherapy (CRT) remains controversial.

Objective: This study aimed to evaluate the ability of deep learning (DL) models to identify patients with LA-HNSCC who can achieve organ preservation through definitive CRT and provide individualized adjuvant treatment recommendations for patients who are better suited for surgery.

Methods: Five models were developed for treatment recommendations.

Classification Prediction of Hydrocephalus After Intercerebral Haemorrhage Based on Machine Learning Approach.

In order to construct a clinical classification prediction model for hydrocephalus after intercerebral haemorrhage(ICH) to guide clinical treatment decisions, this paper retrospectively analyses the clinical data of 844 cases of ICH and hydrocephalus inpatients admitted to Yueyang People's Hospital from May 2019 to October 2022, of which 95 cases of hydrocephalus occurred after ICH and no hydrocephalus in 749 cases. The following indicators were compared between the two groups of patients: gender, age, Glasgow Coma Scale(GCS)score, whether the amount of bleeding was greater than 30 ml, whether it broke into the ventricle or not, modified Graeb score(MGS), modified Rankin Scale (MRS) score, whether surgery was performed or not, red blood cells, white blood cells, and platelets. After variable screening, the following six variables were selected: GCS score, MGS, MRS score, whether the bleeding volume was greater than 30 ml, whether it broke into the ventricle or not, and whether surgery was performed or not were modelled and analysed using logistic regression model and support vector machine model in machine learning.

Foxk2 Enhances Adipogenic Differentiation by Relying on the Transcriptional Activation of Peroxisome Proliferator-Activated Receptor Gamma.

Proper differentiation of bone marrow stromal cells (BMSCs) into adipocytes is crucial for maintaining skeletal homeostasis. However, the underlying regulatory mechanisms remain incompletely understood, posing a challenge for the treatment of age-related osteopenia and osteoporosis. Here, through comprehensive gene expression analysis during BMSC differentiation into adipocytes, we identified the forkhead transcription factor Foxk2 as a key regulator of this process.

Quantifying the contributions of factors to bioaccessible Cd and Pb in soil using machine learning.

The bioaccessibility of cadmium (Cd) and lead (Pb) in the gastrointestinal tract is crucial for health risk assessments of contaminated soils. However, variability in In vitro analytical conditions and soil properties introduces bias and uncertainty in predictions. This study employed three in vitro methods to measure Cd and Pb bioaccessibility during the gastric and gastrointestinal phases, using soil samples incubated for one year.

From marine debris to a valuable medical resource: A review on biology, chemistry, ethnopharmacology, bioactivity and application in biomedical materials of cuttlebone.

Ethnopharmacological Relevance: Cuttlebone (CB), also known as SEPIAE ENDOCONCHA, is the inner shell of cuttlefish and has been employed in traditional medicine in numerous countries since antiquity. Despite its significant medicinal value, CB is often underestimated and discarded on the beach as debris in some countries, which considerably impacts the environment and economy.

The Aim Of The Review: This study aims to elucidate the value of CB, particularly in the context of its medicinal properties, to promote its rational utilization.

A Fluid-Structure Interaction Model of the Zebrafish Aortic Valve.

The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental manipulations. Computational fluid-structure interaction (FSI) simulations are an efficient and highly controllable means to study the function of cardiac valves in development and diseases. Due to their small scales, little is known about the mechanical properties of zebrafish cardiac valves, limiting existing computational studies of zebrafish valves and their interaction with blood.

Transforming dementia research into practice: a multiple case study of academic research utilization strategies in Dutch Alzheimer Centres.

Background: Non-pharmacological dementia research products, such as social and behavioural interventions, are generated in traditional university settings. These often experience challenges to impact practices that they were developed for. The Netherlands established five specialized academic health science centres, referred to as Alzheimer Centres, to structurally coordinate and facilitate the utilization of dementia research knowledge.

IGF2-IGF1R signaling inhibition delays the growth of IGF2-high colorectal cancer by modulating MDSCs.

Approximately 22 % of human colorectal cancers (CRC) are characterized by IGF2 overexpression, and the tumor-promoting role of IGF2 has been widely reported. Despite promising preclinical results, IGF2 signaling inhibition therapy has exhibited limited efficacy in treating unselected patients with CRC. Recent evidence suggests that IGF2-high CRC are more sensitive to IGF2 signaling blockade therapy in immune-deficient mice, suggesting that IGF2-high CRC can benefit from IGF2 signaling blockade therapy.

Fractional Carbon Dioxide Laser Combined with Secukinumab in the Treatment of Refractory Psoriasis Lesions on the Lower Legs.

Psoriasis is a chronic autoimmune skin disorder characterized by high morbidity and a tendency for recurrence. Although biologic therapy for lesion clearance can achieve PASI 90/100, refractory sites remain challenging to completely clear, particularly on the lower legs and elbows. To explore the efficacy of novel treatments for these resistant sites, we present a clinical observation on the safety and effectiveness of fractional carbon dioxide (CO2) laser therapy combined with secukinumab for four patients with moderate-to-severe plaque psoriasis.

Evaluation of the effect of DRG payment policy based on interrupted time series modeling: evidence from a tertiary hospital in Anhui Province.

Background: The payment methodology for diagnosis-related groups (DRG) has implications for both society and medical institutions. Our study aims to analyse the impact of the reform of the payment policy according to the DRG on the operation of a tertiary hospital in Anhui Province.

Methods: Monthly data were collected from April 2020 to September 2023 during the reform period for a tertiary hospital on nine types of operational indicators, including average length of stay (ALOS), number of discharges, number of outpatient visits, percentage of discharged patients undergoing level III or IV surgery, bed turnover rate, inpatient essential drug utilization rate, low-risk group mortality, outpatient subaverage cost and inpatient subaverage cost.

Three-dimensional tracking of organ development in live plants based on plasma membrane dyes at single-cell resolution.

Plant developmental biology necessitates precise three-dimensional (3D) tracking of dynamic processes in live plants, and the 3D imaging technique in developmental bioimaging requires suitable fluorophores to achieve single-cell resolution imaging. Herein, we have designed a series of plasma membrane fluorescent dyes with a number of excellent properties and established a single-cell resolution imaging tool based on these dyes for three-dimensional imaging of various tissues and organs in living plants. The designed plasma membrane fluorescent dyes not only have the advantages of rapid wash-free staining, highly specific targeting, high brightness and high contrast imaging, ultralong imaging time and low biotoxicity, but also effectively avoid the autofluorescence interference of chlorophyll in cells, allowing for the development of a three-dimensional imaging approach of living plant organs with single-cell resolution.

Mentha haplocalyx Briq. (Mint): a comprehensive review on the botany, traditional uses, nutritional value, phytochemistry, health benefits, and applications.

Mentha haplocalyx Briq. (M. haplocalyx), a notable member of the Lamiaceae family, occupies a significant role in the realm of health foods and botanical medicines.

Rapid prediction of acute thrombosis via nanoengineered immunosensors with unsupervised clustering for multiple circulating biomarkers.

The recent SARS-CoV-2 pandemic underscores the need for rapid and accurate prediction of clinical thrombotic events. Here, we developed nanoengineered multichannel immunosensors for rapid detection of circulating biomarkers associated with thrombosis, including C-reactive protein (CRP), calprotectin, soluble platelet selectin (sP-selectin), and D-dimer. We fabricated the immunosensors using fiber laser engraving of carbon nanotubes and CO laser cutting of microfluidic channels, along with the electrochemical deposition of gold nanoparticles to conjugate with biomarker-specific aptamers and antibody.

Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities.

The interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection. In the musculoskeletal system, the soft-hard tissue interfaces at tendon-bone, ligament-bone, and meniscus-bone have been extensively researched as regenerative targets. Similarly, extensive research efforts have been made to guide the regeneration of multi-tissue complexes in periodontium.

Research Progress of Cobalt-Based Metal Organic Frameworks and Their Derivatives in Energy Storage and Conversion.

With the rapid development of modern society, the efficient development and utilization of new energy have become more and more important. The development of high-performance energy storage and conversion devices has a decisive impact on the sustainable and efficient use of energy. In the foreseeable future, the exploration of high-quality functional materials for energy storage and conversion will continue to be the main goal pursued by the scientific and application fields.

Patient voices on PKU care: Insights from focus groups with current and former patients.

Many adults with phenylketonuria (PKU) were discharged from clinics before lifelong treatment guidelines and new therapies. As part of the PKU lost to clinical care study, moderated focus groups were conducted to understand why individuals become lost to care and how to maintain patient engagement. Focus groups involved active clinic patients and those lost to PKU care.

Impact of cognitive impairment on heart failure prognosis: insights into central nervous system mechanism.

Background: Epidemiological studies have indicated that patients with heart failure (HF) who experience cognitive impairment (CI) have a poor prognosis. While poor self-management and compliance are suggested as contributing factors, they do not fully explain the underlying mechanisms of high risk of cardiac events in HF patients with CI. Given the interconnectedness of CI and the autonomic nervous system (ANS), both regulated by the central nervous system, this study investigated the relationship among cognitive function, metabolism in ANS-related brain regions, and major arrhythmic events (MAEs) in patients with HF with reduced ejection fraction (HFrEF).

Prognostic Communication, Symptom Burden, Psychological Distress, and Quality of Life Among Patients With Decompensated Cirrhosis.

Background & Aims: Timely prognostic communication is a critical component of care for patients with decompensated cirrhosis (DC). However, few studies have examined the association of prognostic communication with symptoms, mood, and health-related quality of life (HRQOL) in this population.

Methods: In this cross-sectional study of 218 outpatients with DC, we assessed their self-reported health status (terminally ill vs not terminally ill), their prognostic communication with their hepatologists (Prognosis and Treatment Preferences Questionnaire), symptom burden (Revised Edmonton Symptom Assessment Scale), psychological distress (Hospital Anxiety and Depression Scale), and HRQOL (Short-Form Liver Disease Quality of Life scale).

Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice.

Naked cuticle homolog 2 (NKD2) has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor. The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully understood. In this study, we identified the up-regulation of NKD2 during osteoblast and adipocyte differentiation.

Development and validation of a nomogram for predicting early acute hydrocephalus after spontaneous intracerebral hemorrhage: a single-center retrospective study.

Acute hydrocephalus is a severe complication that may occur early after an intracerebral hemorrhage (ICH). However, clinical factors predicting the occurrence of acute hydrocephalus have rarely been studied. This study aimed to establish a nomogram model to predict early acute hydrocephalus after ICH.