Isolation and characterization of a broad-spectrum bacteriophage against multi-drug resistant Escherichia coli from waterfowl field.

Escherichia coli (E. coli) is a significant pathogen responsible for intestinal infections and foodborne diseases. The rise of antibiotic resistance poses a significant challenge to global public health.

Improvement of upper limb function in post-stroke patients with motion feedback training-based combination therapy: a retrospective analysis of muscle activation and recovery dynamics.

Objective: To evaluate the effectiveness of combination therapy based on motion feedback training in patients recovering from ischemic stroke.

Methods: A retrospective analysis was conducted on 205 patients in the recovery phase of ischemic stroke admitted between June 2022 and June 2023. Patients were divided into two groups: the conventional treatment group (n=101), receiving standard care, and the combination therapy group (n=104), receiving additional motion feedback training for 30 days.

Association of Preoperative Walking Speed With 1-Year Outcomes After Hip Arthroscopy for Femoroacetabular Impingement Syndrome.

Background: Previous studies have identified demographic, radiographic, and intraoperative predictors of outcomes after hip arthroscopy for femoroacetabular impingement syndrome, yet few studies have identified whether preoperative gait metrics can predict outcomes.

Hypothesis: Increased preoperative step count, walking speed, step length, and gait symmetry will be associated with better outcomes after surgery.

Study Design: Retrospective cohort study.

Transarterial chemoembolization combined with lenvatinib and sintilimab lenvatinib alone in intermediate-advanced hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer that has limited treatment options and a poor prognosis. Transarterial chemoembolization (TACE) is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia, thereby promoting angiogenesis. Recent studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might improve efficacy.

The high levels of fibrinogen and platelets are associated with poor survival in nephroblastoma in children.

Background: Pediatric nephroblastoma is the most common abdominal malignancy in children. Hyperfibrinogenemia and thrombocytosis are often associated with malignancy and poor prognosis. This study aimed to investigate the relationship between high fibrinogen and platelet levels and the clinicopathologic features as well as overall survival in pediatric nephroblastoma.

3D Covalent Organic Framework Membrane with Interactive Ion Nanochannels for Hydroxide Conduction.

Crystalline porous materials, known for their ordered structures, hold promise for efficient hydroxide conductivity in alkaline fuel cells with limited ionic densities. However, the rigid cross-linking of porous materials precludes their processing into membranes, while composite membranes diminish materials' conductivity advantage due to the interrupted phases. Here, we report a self-standing three-dimensional covalent organic framework (3D COF) membrane with efficient OH-transport through its interconnected 3D ionic nanochannels.

The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial.

Objective: To evaluate whether the immunomodulatory drug thymosin α1 reduces mortality in adults with sepsis.

Design: Multicentre, double blinded, placebo controlled phase 3 trial.

Setting: 22 centres in China, September 2016 to December 2020.

A phase 1 trial of prizloncabtagene autoleucel, a CD19/CD20 CAR T-cell therapy for relapsed/refractory B-cell non-Hodgkin lymphoma.

Prizloncabtagene autoleucel (prizlon-cel), a novel bispecific chimeric antigen receptor (CAR) T-cell, targets and eliminates CD19/CD20 positive tumor cells. This phase 1, open-label study investigated the safety and efficacy of prizlon-cel in patients with relapsed/refractory B-cell non-Hodgkin Lymphoma (r/r B-NHL). Patients with CD19 and/or CD20-positive r/r B-NHL received a 3-day lymphodepletion (cyclophosphamide: 300 mg/m2/d; fludarabine: 30 mg/m2/d) followed by an intravenous dose of prizlon-cel.

Compensatory effect-based oxidative stress management microneedle for psoriasis treatment.

Reactive oxygen species (ROS) at elevated levels trigger oxidative DNA damage, which is a significant factor in psoriasis exacerbation. However, normal ROS levels are essential for cell signaling, cell growth regulation, differentiation, and immune responses. To address this, we developed ROS control strategies inspired by compensatory effects.

Phase transition in magic with random quantum circuits.

Magic is a property of quantum states that enables universal fault-tolerant quantum computing using simple sets of gate operations. Understanding the mechanisms by which magic is created or destroyed is, therefore, a crucial step towards efficient and practical fault-tolerant computation. We observe that a random stabilizer code subject to coherent errors exhibits a phase transition in magic, which we characterize through analytic, numeric and experimental probes.

Microneedles as transdermal drug delivery system for enhancing skin disease treatment.

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding a viable resolution to the formidable barriers presented by the cutaneous interface. This review examines MNs as an advanced approach to enhancing dermatological pathology management. It explores the complex dermis structure and highlights the limitations of traditional transdermal methods, emphasizing MNs' advantage in bypassing the stratum corneum to deliver drugs directly to the subdermal matrix.

Effects of thermal treatment and Glucono-δ-lactone on the quality of alkaline dough and steamed buns.

In the present study, the effects of glucono-δ-lactone (GDL) as an acid reagent during thermal treatment on the quality of alkaline dough and steamed buns were examined. During the heating process, GDL improved the viscoelasticity and fluidity of the alkaline dough and enhanced intermolecular hydrogen bonding. The hardness of steamed buns was reduced by 61.

Arctic soil carbon insulation averts large spring cooling from surface-atmosphere feedbacks.

The insulative properties of soil organic carbon (SOC) and surface organic layers (moss, lichens, litter) regulate surface-atmosphere energy exchanges in the Arctic through a coupling with soil temperatures. However, a physical description of this process is lacking in many climate models, potentially biasing their high-latitude climate predictions. Using a coupled surface-atmosphere model, we identified a strong feedback loop between soil insulation, surface air temperature, and snowfall.

ATXN2 polyglutamine intermediate repeats length expansions in Malaysian patients with amyotrophic lateral sclerosis (ALS).

Intermediate CAG repeats from 29 to 33 in the ATXN2 gene contributes to the risk of amyotrophic lateral sclerosis (ALS) in European and Asian populations. In this study, 148 ALS patients of multiethnic descent: Chinese (56.1%), Malay (24.

Neoadjuvant adebrelimab combined with chemotherapy (cisplatin/carboplatin and etoposide) for limited-stage small-cell lung cancer: a study protocol of phase 2 trial (NIUS).

Introduction: Small-cell lung cancer (SCLC) is a highly malignant neuroendocrine tumour, and concurrent chemoradiotherapy is the current recommended treatment for limited-stage SCLC. However, the overall survival (OS) of patients with SCLC remains poor. Therefore, improving the survival of patients with SCLC and benefitting more patients are urgent clinical requirements.

Y-27632 and dual media culture approach promote the construction and transplantation of rabbit limbal epithelial cell sheets via cell spheroid culture and auto-bioprinting.

The shortage of corneal donors and the limitations in tissue engineering grafts, such as biocompatibility and mechanical properties, pose significant challenges in corneal transplantation. Here, for the first time, we investigate the effect of Rho kinase inhibitor Y-27632 and a dual media culture approach, including proliferative media (M1) and stabilizing media (M2), on rabbit limbal epithelial stem cells (LESCs), aiming to explore the feasibility of constructing corneal cell sheets in vitro through auto-bioprinting and assessing their corneal wound healing capacity in vivo. Y-27632 has primarily demonstrated significantly enhanced LESCs growth, proliferation, and reduced apoptosis.

5-Methylcytosine-modified circRNA-CCNL2 regulates vascular remdeling in hypoxic pulmonary hypertension through binding to FXR2.

Pulmonary hypertension (PH) is a malignant cardiovascular disease with a complex etiology. 5-Methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant RNAs, with a lower frequency of occurrence in circular RNAs (circRNAs). Nevertheless, the function of m5C-modified circRNAs in the pathogenesis of PH remains uncertain.

Influence of Heat- and Cold-Stressed Raw Milk on the Stability of UHT Milk.

This study investigated the variations and alterations in the concentrations of plasmin system components in raw and UHT (ultra-high-temperature) milk under cold stress (WCT ≤ -25 °C), heat stress (THI ≥ 80), and normal (THI < 70 and WCT ≥ -10 °C) circumstances. The findings indicated elevated amounts of plasmin system components in cold-stressed raw milk. While storing UHT milk at 25 °C, the concentrations and activity of plasmin in the milk exhibited an initial increase followed by a decrease, peaking around the 30th day.

Comparison of bioabsorbable screw versus metallic screw fixation for tibial tubercle fractures in adolescents: a retrospective cohort study.

Background: Displaced tibial tubercle (TT) fractures in adolescents are typically treated with open reduction and internal fixation. While metallic screw (MS) fixation provides strong stability, it often results in a high incidence of postoperative screw head protrusion or irritation, leading to additional removal surgery. Bioabsorbable screw (BS) fixation presents an alternative that may avoid these issues, though its stability has not yet been extensively documented in the literature.

Strategies for phosphorus management and greenhouse gas reduction via plant harvesting in the water-level fluctuation zone of the Three Gorges Reservoir.

The water-level fluctuation zones (WLFZ) in Three Gorges Reservoir encounter several ecological challenges, particularly potential greenhouse gas (GHG) emissions and water eutrophication due to water level variations. Therefore, to address those challenges, our study explores the relationships between soil properties (Phosphorus cycle), plant conditions, microbial community, and GHG emissions. Our findings reveal that aboveground plants are the key link in the WLFZ ecosystem, which has previously been overlooked.

Self-calibrating temperature sensing strategy based on KBaY(MoO):Pr phosphor luminescence characteristics with excellent relative temperature sensitivity.

Non-contact temperature sensors have gained immense popularity due to their inherent benefits, including the absence of physical interaction with targets and rapid response characteristics. In this work, KBaY(MoO):Pr was successfully synthesized utilizing a high-temperature solid-phase method. Experimental studies have indicated that multi-phonon relaxation (MPR), cross-relaxation (CR), and the unique intervalence charge transfer state (IVCT) exhibited by Pr-Mo contribute to the changes in luminescence properties.

PAMAM/miR-144 nanocarrier system inhibits the migration of gastric cancer by targeting mTOR signal transduction pathway.

Exogenous microRNA-144 (miR-144) is considered as a potential biological drug for gastric cancer because of its biological activity to inhibit the epithelial-mesenchymal transition (EMT). However, the specific molecular mechanisms have not been fully revealed. In addition, their vulnerability to degradation by RNA enzymes in the blood limits their bioavailability.

Infectious keratitis following photorefractive keratectomy: a 13-year study at a tertiary center.

Introduction: Infectious keratitis is a rare but devastating complication following photorefractive keratectomy (PRK) that may lead to visual impairment. This study assessed the clinical features, treatment strategies, and outcomes of post-PRK infectious keratitis.

Methods: This retrospective study was conducted on patients with post-PRK infectious keratitis presenting to Khalili Hospital, Shiraz, Iran, from June 2011 to March 2024.