Gastrointestinal absorption and its regulation of hawthorn leaves flavonoids.

Hawthorn leave flavonoids (HLF) are widely used as an herb or dietary supplements for cardio-cerebrovascular diseases. However, its gastrointestinal absorption behavior and mechanism have not been disclosed. In this study, gastrointestinal absorption and its regulation of 4''-O-glucosylvitexin (GLV), 2''-O-rhamnosylvitexin (RHV), vitexin (VIT), rutin (RUT) and hyperoside (HP) in HLF were investigated using in vitro, in situ and in vivo models.

Efficient and Stable Inverted Perovskite Solar Cells Enabled by Inhibiting Voids via a Green Additive.

The buried interface in inverted perovskite solar cells (PSCs) is critical for determining device performance. However, during annealing, the perovskite crystallized downward from the film's top surfaces, and the use of dimethyl sulfoxide (DMSO) often resulted in voids at the perovskite bottom surface, which negatively impacted PSC performance. In this study, a green solid-state additive, piracetam (PA), was introduced into a perovskite precursor to reduce void formation.

Reconstruction of Hole Transport Layer via Co-Self-Assembled Molecules for High-Performance Inverted Perovskite Solar Cells.

Adjusting the hole transport layer (HTL) to optimize its interface with perovskite is crucial for minimizing interface recombination, enhancing carrier extraction, and achieving efficient and stable inverted perovskite solar cells (PSCs). However, as a commonly used HTL, the self-assemble layer (SAM) of [2-(3,6-dimethoxy-9H-carbazol-9-yl)ethyl] phosphonic acid (MeO-2PACz) tends to form clusters and micelles during the deposition process, leading to inadequate coverage of the ITO substrate. Here, a Co-SAM strategy is employed by incorporating 4-mercaptobenzoic acid (SBA) and 4-trifluoromethyl benzoic acid (TBA) as additives into MeO-2PACz to fabricate a Co-SAM-based HTL.

Effectiveness and safety of exercise training and rehabilitation in elderly patients after heart valve intervention: A systematic review and meta-analysis of randomized controlled trials.

Objective: To investigate the effectiveness and safety of exercise rehabilitation in older adults undergoing intervention for heart valve disease.

Method: PubMed, Embase, Cochrane Library, CINAHL, Ovid Medline, SPORTDiscus, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang were systematically searched until January 2024. Risk-of-bias assessments were performed using the Cochrane risk-of-bias tool.

Tensorial multiview low-rank high-order graph learning for context-enhanced domain adaptation.

Unsupervised Domain Adaptation (UDA) is a machine learning technique that facilitates knowledge transfer from a labeled source domain to an unlabeled target domain, addressing distributional discrepancies between these domains. Existing UDA methods often fail to effectively capture and utilize contextual relationships within the target domain. This research introduces a novel framework called Tensorial Multiview Low-Rank High-Order Graph Learning (MLRGL), which addresses these challenges by learning high-order graphs constrained by low-rank tensors to uncover contextual relations.

Effects of cognitive training on cognitive function in patients after cardiac surgery: A systematic review and meta-analysis of randomized controlled trials.

Background: Postoperative cognitive deficits frequently occur in patients undergoing cardiac surgery, leaving them with reduced cognitive function. Cognitive training has been shown to improve cognitive function, however, the role in patients after cardiac surgery is unclear. In this study, we aimed to evaluate the effectiveness and safety of cognitive training in patients undergoing cardiac surgery.

Rational construction of a high-quality and high-efficiency biosynthetic system and fermentation optimization for A82846B based on combinatorial strategies in Amycolatopsis orientalis.

Background: Oritavancin is a new generation of semi-synthetic glycopeptide antibiotics against Gram-positive bacteria, which served as the first and only antibiotic with a single-dose therapeutic regimen to treat ABSSSI. A naturally occurring glycopeptide A82846B is the direct precursor of oritavancin. However, its application has been hampered by low yields and homologous impurities.

Endoglucanase H from Plays an Important Role in the Virulence on Pear Fruits.

can infect many agricultural products including cereals, grapes, and pear. Pathogenic fungi secrete diverse effectors as invasive weapons for successful invasion the host plant. During the pathogen-host interaction, 4486 differentially expressed genes were observed in with 2773 up-regulated and 1713 down-regulated, whereas 8456 differentially expressed genes were detected in pear fruits with 4777 up-regulated and 3679 down-regulated.

Chitosan inhibits Penicillium expansum possibly by binding to DNA and triggering apoptosis.

Chitosan is a natural polysaccharide that is abundant, biocompatible and exhibits effective antifungal activity against various pathogenic fungi. However, the potential intracellular targets of chitosan in pathogenic fungi and the way of activity of chitosan are far from well known. The present work demonstrated that chitosan could inhibit Penicillium expansum, the principal causal agent of postharvest blue mold decay on apple fruits, by binding to DNA and triggering apoptosis.

Daptomycin production enhancement by ARTP mutagenesis and fermentation optimization in Streptomyces roseosporus.

Aims: We evaluated whether the randomness of mutation breeding can be regulated through a double-reporter system. We hope that by establishing a new precursor feeding strategy, the production capacity of industrial microorganisms after pilot scale-up can be further improved.

Methods And Results: In this study, the industrial strain Streptomyces roseosporus L2796 was used as the starter strain for daptomycin production, and a double-reporter system with the kanamycin resistance gene Neo and the chromogenic gene gusA was constructed to screen for high-yield strain L2201 through atmospheric and room temperature plasma (ARTP).

SuperUDF: Self-Supervised UDF Estimation for Surface Reconstruction.

Learning-based surface reconstruction based on unsigned distance functions (UDF) has many advantages such as handling open surfaces. We propose SuperUDF, a self-supervised UDF learning which exploits a learned geometry prior for efficient training and a novel regularization for robustness to sparse sampling. The core idea of SuperUDF draws inspiration from the classical surface approximation operator of locally optimal projection (LOP).

[Weidiao-3 Mixture Improves the Clinical Efficacy of Immunotherapy for Advanced Gastric Cancer by Regulating Intestinal Flora].

Objective To investigate the effects of Weidiao-3(WD-3)Mixture on the clinical efficacy of immunotherapy for advanced gastric cancer and the intestinal flora.Methods Fifty-one patients with advanced gastric cancer treated in Wuxi Traditional Chinese Medicine Hospital from January 2020 to December 2021 were randomized into a WD-3 group(immunotherapy + WD-3 Mixture,one dose per day)(=25)and a gastric cancer(GC) group(only immunotherapy)(=26)according to the admission time.Ten healthy volunteers were included as the healthy control group.

Comprehension of rectosigmoid junction cancer molecular features by comparison to the rectum or sigmoid colon cancer.

Background: Colorectal cancer (CRC) is a heterogeneous cancer. Its treatment depends on its anatomical site and molecular features. Carcinomas of the rectosigmoid junction are frequent; however, specific data on these tumors are sparse, as they are frequently assigned to either the colon or rectum.

Identification and Characterization of a New Regulator, TagR, for Environmental Stress Resistance Based on the DNA Methylome of Streptomyces roseosporus.

DNA methylation is a defense that microorganisms use against extreme environmental stress, and improving resistance against environmental stress is essential for industrial actinomycetes. However, research on strain optimization utilizing DNA methylation for breakthroughs is rare. Based on DNA methylome analysis and KEGG pathway assignment in Streptomyces roseosporus, we discovered an environmental stress resistance regulator, TagR.

OncoVee™-MiniPDX-guided anticancer treatment for HER2-negative intermediate-advanced gastric cancer patients: a single-arm, open-label phase I clinical study.

Background: Chemotherapy is the main treatment strategy for patients with advanced HER2-negative gastric cancer (GC); yet, many patients do not respond well to treatment. This study evaluated the sensitivity of a mini patient-derived xenograft (MiniPDX) animal model in patients with HER2-negative intermediate-advanced GC.

Methods: In this single-arm, open-label clinical study, we consecutively recruited patients with HER2-negative advanced or recurrent GC from September 2018 to July 2021.

Degradation mechanism of AtrA mediated by ClpXP and its application in daptomycin production in Streptomyces roseosporus.

The efficiency of drug biosynthesis depends on different transcriptional regulatory pathways in Streptomyces, and the protein degradation system adds another layer of complexity to the regulatory processes. AtrA, a transcriptional regulator in the A-factor regulatory cascade, stimulates the production of daptomycin by binding to the dptE promoter in Streptomyces roseosporus. Using pull-down assays, bacterial two-hybrid system and knockout verification, we demonstrated that AtrA is a substrate for ClpP protease.

Experimental study on reducing the viscosity of sewage containing PAM catalyzed by low temperature plasma synergistic AC/Mn + TiO.

With the wide application of polymer flooding technology in oil fields, wastewater containing PAM (polyacrylamide) is produced. Its high viscosity makes it difficult to degrade. In this paper, the low-temperature plasma produced by DBD (Dielectric Barrier Discharge) was studied to reduce the viscosity of wastewater containing PAM under the synergistic action of AC (Activated carbon)/Mn + TiO catalyst.

How pom cheerleading improves the executive function of preschool children: the mediating role of speed and agility.

Physical exercises can improve individuals' physical health and cognition, but the internal influence path is unclear. This study aims to examine the influence of pom cheerleading training on physical fitness and executive function of preschool children and explore the relationship between sports training, physical fitness, and executive function. We selected seventy-one preschool children and divided them into the experimental group (n = 36) and the control group (n = 35).

ACP-check: An anticancer peptide prediction model based on bidirectional long short-term memory and multi-features fusion strategy.

The anticancer peptide is an emerging anticancer drug that has become an effective alternative to chemotherapy and targeted therapy due to fewer side effects and resistance. The traditional biological experimental method for identifying anticancer peptides is a time-consuming and complicated process that hinders large-scale, rapid, and effective identification. In this paper, we propose a model based on a bidirectional long short-term memory network and multi-features fusion, called ACP-check, which employs a bidirectional long short-term memory network to extract time-dependent information features from peptide sequences, and combines them with amino acid sequence features including binary profile feature, dipeptide composition, the composition of k-spaced amino acid group pairs, amino acid composition, and sequence-order-coupling number.

Improving the Yield and Quality of Daptomycin in by Multilevel Metabolic Engineering.

Daptomycin is a cyclic lipopeptide antibiotic with a significant antibacterial action against antibiotic-resistant Gram-positive bacteria. Despite numerous attempts to enhance daptomycin yield throughout the years, the production remains unsatisfactory. This study reports the application of multilevel metabolic engineering strategies in to reconstruct high-quality daptomycin overproducing strain L2797-VHb, including precursor engineering (i.

A novel strategy of gene screen based on multi-omics in Streptomyces roseosporus.

Daptomycin is a new lipopeptide antibiotic for treatment of severe infection caused by multi-drug-resistant bacteria, but its production cost remains high currently. Thus, it is very important to improve the fermentation ability of the daptomycin producer Streptomyces roseosporus. Here, we found that the deletion of proteasome in S.

Multiphoton upconversion and non-resonant optical nonlinearity in perovskite quantum dot doped glasses.

By incorporating the quantum dots (QDs) into a glass host, we report for the first time, to our knowledge, the measurement of non-resonant optical nonlinearity and multiphoton upconversion (UC) processes for this QD-in-glass composite. We observe up to four-photon stable UC photoluminescence under excitation by infrared femtosecond pulses, low optical limiting thresholds, and high nonlinear optical absorption coefficients close to those of colloid processed metal halide perovskite (MHP) QDs. Combined with high robustness against air and moisture, the monolithic inorganic glass with incorporated MHP QDs could be a better platform for exploiting strong light-matter interaction for MHPs.