Genome-Wide Identification of the Gene Family and the Function of Under Salt Stress.

A comprehensive genome-wide identification of SET-domain-containing genes in (tomato) has revealed 46 members. Phylogenetic analysis showed that these genes, along with those from and , are divided into five subfamilies, with Subfamilies II and V being the largest. Motif and domain analyses identified 15 conserved motifs and revealed the presence of pre-SET and post-SET domains in several genes, suggesting functional diversification.

Potential of G-6 for Biocontrol of Cucumber Wilt Disease and Growth Enhancement.

Cucumber wilt disease, caused by f. sp. (FOC), is a major threat to cucumber production, especially in greenhouses.

Analysis of tirzepatide in the US FDA adverse event reporting system (FAERS): a focus on overall patient population and sex-specific subgroups.

Objective: Tirzepatide, a novel GIP and GLP1 agonist, has been extensively examined in clinical trials. However, specific data on its adverse drug events (ADEs) remain limited. This study aims to comprehensively assess real-world ADEs associated with tirzepatide by mining data from the U.

Research on disease management of chronic disease patients based on digital therapeutics: A scoping review.

Background: The prevalence of chronic diseases is rising annually due to the aging of the population, and these illnesses constitute a major cause of mortality. Digital therapeutics (DTx) is a promising solution for the prevention and management of chronic diseases. With the rapid advancement of information technology in recent years, software algorithms or applications based on clinical assessment, evidence, and technology can be used to directly provide digital medical interventions to patients to promote disease management.

Causal association between thyroid function and the risk of infertility: a Mendelian randomization study.

Objectives: Thyroid dysfunction is commonly associated with the risk of infertility in both females and males. However, recent randomized controlled trials have demonstrated that thyroid function levels in females are not significantly related to infertility, and evidence on the association between male thyroid function and infertility is limited. We aim to investigate the association between thyroid function levels and infertility in both females and males.

Research on the aerodynamic characteristics of dragonfly leading edge.

Dragonflies are some of the most stable and maneuverable flying organisms. To explore the mechanism of how dragonfly leading edges enhance flight lift, this article conducts a detailed study on the leading edge veins and the microstructures on them of dragonfly wings. Observations have discovered the special leading edge vein and the regularly distributed microstructures on the leading edge vein.

Adverse drug events associated with linezolid administration: a real-world pharmacovigilance study from 2004 to 2023 using the FAERS database.

Linezolid is an oxazolidinone antibiotic that is active against drug-resistant Gram-positive bacteria and multidrug-resistant . Real-world studies on the safety of linezolid in large populations are lacking. This study aimed to determine the adverse events associated with linezolid in real-world settings by analyzing data from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).

Silica Nanoparticle Exposure Implicates β-Amyloid (1-42) Inbound and the Accelerating Alzheimer's Disease Progression in Mice Overexpressing Mutated Forms of Human Amyloid Precursor Protein and Presenilin 1 Genes.

The increasing nanoparticle (NP) applications in the biomedical field have become an emerging concern regarding human health. NP exposure may play a role in the accelerating Alzheimer's disease (AD) progression; however, the etiology of this disorder is complex and remains largely unclear. Here, we identified that intravenous injection of silica NPs (SiNPs) caused the blood-brain barrier breakdown via downregulating tight junction-related gene expressions.

A real-world pharmacovigilance study of mepolizumab in the FDA adverse event reporting system (FAERS) database.

Mepolizumab is primarily used in the treatment of asthma, eosinophilic granulomatosis with polyangiitis, eosinophilia syndrome, and chronic rhinitis with nasal polyps. The information about its adverse drug reactions is mainly derived from clinical trials, and there is a shortage of real-world studies with extensive sample sizes. In this study, the U.

Investigation and analysis of pin-point damage and damage growth characteristics in KDP and DKDP crystals.

In this paper, we report the damage and damage growth in potassium dihydrogen phosphate and its deuterated analog crystals. A time-resolved shadow imaging system was used to investigate the damage behavior in the bulk and on the rear surface. The damage images show differences in the damage sizes of the crystals with different deuterization rates.

Malaria sporozoites evade host complement attack.

Complement is the first line of the host innate immune response against bacterial and viral infections; however, its role in the development of the malaria liver stage remains undefined. We found that sporozoite infection by either a mosquito bite or intravenous injection activated systemic complement, but neither depletion of C3 nor knockout of C3 had a significant effect on malaria liver stage development. Incubation of mouse serum with trypsin-treated sporozoites, but not naive sporozoites, led to the deposition of a membrane attack complex (MAC) on the surface of sporozoites and greatly reduced the number of exo-erythrocytic forms (EEF).

ZIF-8-Derived Carbon In-Situ Encapsulated Hollow MnSiO Sub-Microspheres as Anode for Lithium-Ion Batteries with Ultrahigh Capacity and Excellent Rate Performance.

Manganese silicate (MnSiO) possesses a more suitable volume expansion (186%) compared to SiO-based materials and is also characterized by low cost, environmental friendliness, and considerable theoretical capacity. Hollow MnSiO sub-microspheres encapsulated by a highly continuous network of conductive carbon (MSC) are prepared by the self-templating method and subsequent ZIF-8-derived carbon coating. The as-prepared MnSiO@C hybrid under optimal conditions (MSC-2) can provide a high capacity of 1343 mA h g at 0.

Exercise improved bone health in aging mice: a role of SIRT1 in regulating autophagy and osteogenic differentiation of BMSCs.

Introduction: This study was designed to investigate the effect of running exercise on improving bone health in aging mice and explore the role of the SIRT1 in regulating autophagy and osteogenic differentiation of Bone marrow Mesenchymal Stem Cells (BMSCs).

Methods: Twelve-month-old male C57BL/6J mice were used in this study as the aging model and were assigned to treadmill running exercise for eight weeks. Non-exercise male C57BL/6J mice of the same old were used as aging control and five-month-old mice were used as young controls.

Influence of the laser pulse time profile on residual stress characteristics in laser shock peening.

In this paper, residual stress and plastic deformation of TC4 titanium alloys and AA7075 aluminum alloys after laser shock peening (LSP) with the laser pulses that have the same energy and peak intensity but different time profiles have been studied. The results show that the time profile of the laser pulse has a significant influence on LSP. The difference between the results of LSP with varying laser input mode has been contributed to the shock wave caused by different laser pulse.

Surface Cleanliness Maintenance with Laminar Flow Based on the Characteristics of Laser-Induced Sputtering Particles in High-Power Laser Systems.

In high-power laser systems, the primary cause of contamination of optical components and degradation of spatial cleanliness is laser-induced sputtering of particles. To mitigate this problem, laminar flow is frequently utilized to control the direction and transport of these particles. This study characterizes the properties of laser-induced sputtering particles, including their flying trend, diameter range, and velocity distribution at varying time intervals.

An overview of brain-like computing: Architecture, applications, and future trends.

With the development of technology, Moore's law will come to an end, and scientists are trying to find a new way out in brain-like computing. But we still know very little about how the brain works. At the present stage of research, brain-like models are all structured to mimic the brain in order to achieve some of the brain's functions, and then continue to improve the theories and models.

The distinctive role of membrane fibrinogen-like protein 2 in the liver stage of rodent malaria infections.

Viral infection often induce the expression of murine fibrinogen-like protein 2 (mFGL2) triggering immune coagulation, which causes severe liver pathogenesis via increased fibrin deposition and thrombosis in the microvasculature. We aimed to investigate the role of mFGL2 in the liver stage of malaria infections. We reveal that infection with malaria sporozoites also induces increased expression of mFGL2 and that this expression is primarily located within the liver Kupffer and endothelial cells.

Synergistic Optimization Strategy Involving Sandwich-like MnO@rGO and Laponite-Modified PAM for High-Performance Zinc-Ion Batteries and Zinc Dendrite Suppression.

Optimization of the cathode structure and exploration of a novel electrolyte system are important approaches for achieving high-performance zinc-ion batteries (ZIBs) and zinc dendrite suppression. Herein, a quasi-solid-state ZIB combining a sandwich-like MnO@rGO cathode, a laponite (Lap)-modified polyacrylamide (PAM) hydrogel electrolyte, and an electrodeposited zinc anode is designed and constructed by a synergistic optimization strategy. The MnO composite prepared through the intercalation of rGO shows developed mesopores, providing accessible ion transport channels and exhibiting a high electrical conductivity.

Evolution of laser-induced bulk damage in KDP crystal.

Pinpoint damage is the main type of bulk damage in potassium dihydrogen phosphate (KDP) crystals in high-power lasers. Using time-resolved microimaging, we observed the complete dynamic evolution of pinpoint damage in a KDP crystal. We analyzed changes in the patterns of dark zones formed by decreasing probe transmittance in transient images throughout the process.

Niobium Tungsten Oxides for Electrochromic Devices with Long-Term Stability.

There is a keen interest in the use of electrochromic materials because they can regulate light and heat, thereby reducing the cooling and heating energy. However, the long response time, short cycle life, and high power consumption of an electrochromic film hinder its development. Here, we report an electrochromic material of complex niobium tungsten oxides.

[Construction and Identification of Acute Myeloid Leukemia NOD/SCID Mouse Model by Tail Vein Injection of THP-1 Cells].

Objective: To construct NOD/SCID mouse leukemia model by using THP-1 cells.

Methods: Eighteen female NOD/SCID mice aged 3 to 4 weeks were randomly divided into control group, model group A and model group B (6 in each group). Before inoculation, each mouse was intraperitoneally injected with cyclophosphamide 2 mg/(kg·d) for 2 d, and the mice in model groups were inoculated with cells within 24 h after pretreatment.

Investigation of stress wave and damage morphology growth generated by laser-induced damage on rear surface of fused silica.

In this study, stress wave and damage morphology on the rear surface of silica during laser induced damage with cumulative UV pump shots is investigated. Time resolved imaging system, along with stress induced birefringence detecting, is used to demonstrate the development of stress wave. The properties of three types of stress waves, namely, compressive wave (P-wave), shear wave (S-wave), and Rayleigh wave (R-wave) are recorded and studied during the damage process.

Ultrasensitive Electrochemical Immunosensor Reveals the Existence of Silk Products on the Maritime Silk Road.

The Maritime Silk Road was the major trade route between eastern and western civilizations in the Middle Ages. However, hardly any silk products have been found along the transoceanic trade route. Thus, the extrasensitive detection of silk relic traces has tremendous importance in research regarding the Maritime Silk Road.

Tailored monoclonal antibody as recognition probe of immunosensor for ultrasensitive detection of silk fibroin and use in the study of archaeological samples.

The ultrasensitive detection of fibroin in unearthed silk relics has great significance for investigating the origin and transmission of silk. In this study, an anti-fibroin monoclonal antibody was successfully prepared through animal immunization. Next, a label-free electrochemical immunosensor was fabricated using layer-by-layer self-assembly technology, and an indirect enzyme-linked immunosorbent assay (ELISA) was proposed.