Influence of pulsed electric field and glycerol pretreatments on freeze-thaw process and quality of white radish.

This study focused on the effects of pulsed electric field (PEF) and glycerol (G) pretreatments on the quality of freeze-thawed white radishes. The optimal PEF strength, frequency, and treatment time were 800 V/cm, 5 Hz, and 0.1 s, respectively.

Post-market safety profile of cefiderocol: a real-world pharmacovigilance exploratory analysis based on U.S. FDA adverse event reporting system (FAERS).

Background: Cefiderocol is a new drug class, which is approved to treat Gram-negative bacteria infection. Its approval for marketing has provided clinicians with additional options for treating antimicrobial resistant gram-negative infections. The aim of our study was to assess the safety profiles of cefiderocol in real-world through data mining of the United States Food and Drug Administration Adverse Event Reporting System (FAERS).

Comparative efficacy and safety of bicompartmental versus total knee arthroplasty: a systematic review and update meta-analysis.

Background: This study was aimed at comparing the efficacy and safety of bicompartmental knee arthroplasty (BKA) and total knee arthroplasty (TKA) in treating bicompartmental knee osteoarthritis through a systematic evaluation and meta-analysis.

Methods: A comprehensive systematic literature search of the Pub Med, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov databases was performed to identify the relevant scientific literature published until 1st March 2024.

Genome-wide identification of the UGT genes family in Acer rubrum and role of ArUGT52 in anthocyanin biosynthesis under cold stress.

Acer rubrum is a widespread Acer species valued for its vibrant autumn foliage. The UGT (UDP-glycosyltransferase) gene family is integral to the biosynthesis of anthocyanins, the pigments responsible for leaf coloration. This study aimed to comprehensively identify and characterize the UGT gene family in the A.

Implicit-explicit Integrated Representations for Multi-view Video Compression.

With the increasing consumption of 3D displays and virtual reality, multi-view video has become a promising format. However, its high resolution and multi-camera shooting result in a substantial increase in data volume, making storage and transmission a challenging task. To tackle these difficulties, we propose an implicit-explicit integrated representation for multi-view video compression.

MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1-mediated oxidative phosphorylation.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by disrupted bone homeostasis. This study investigated the effect and underlying mechanisms of one-carbon metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) on osteoclast differentiation and bone loss in RA.

Methods: The expression of MTHFD2 was examined in CD14 + monocytes and murine bone marrow-derived macrophages (BMMs).

Cancer Recurrence Fear and Return to Work in Breast Cancer Survivors:The Mediating Effects of Health Literacy.

Purpose: This study investigates the relationships between breast cancer survivors' return to work, health literacy, and cancer recurrence fear. By employing structural equation modeling, we examine the mediating effect of health literacy on the interplay between cancer recurrence fear and the ability to return to work.

Patients And Methods: We conducted a survey involving 190 breast cancer survivors, utilizing a general information questionnaire, the Concern About Recurrence Scale, and the Health Literacy Management Scale.

Enhancing Pain Assessment Among Post-Surgery Patients at a Tertiary Hospital in China: A Best Practice Implementation Project.

Background: Postoperative pain is a common complication that can delay recovery and increase hospital stays and costs. Accurate pain assessments are essential for effective management.

Local Problem: Compliance with evidence-based pain assessment protocols in the Anesthesia Intensive Care Unit (AICU) at a teaching hospital in Hefei, China, was suboptimal.

Plasma proteomic profiles predict individual future osteoarthritis risk.

Objective: Osteoarthritis (OA) is a widespread degenerative joint disease that causes a considerable socioeconomic burden. Despite progress in genetic and environmental insights, early diagnosis is still limited by the lack of evident symptoms during the initial phases and accurate biomarkers. This study aims to identify plasma proteins associated with future risk of OA and develop a predictive model.

Targeting stromal cells in tumor microenvironment as a novel treatment strategy for glioma.

Glioma is the most common primary malignant tumor of the central nervous system in adults, characterized by high mortality, low cure rate and high recurrence rate. Among gliomas, glioblastoma multiforme (GBM) is the most malignant subtype. Currently, the standard treatment for patients with GBM is maximum surgical excision combined with radiotherapy and chemotherapy.

Therapy-Related Leukemia following Docetaxel Chemotherapy for Metastatic Hormone-Sensitive Prostate Cancer: A Case Report.

Introduction: Docetaxel is the first-line drug that has been proved to improve the overall survival of men with metastatic hormone-sensitive prostate cancer (mHSPC). For patients who survive the prostate cancer, they may be at risk of secondary neoplasm, especially for the therapy-related myelodysplastic syndrome or therapy-related acute myeloid leukemia (t-AML).

Case Presentation: We reported a 44-year-old man with prostate cancer (cT4N1M1c) who developed t-AML following docetaxel chemotherapy.

Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke.

Background: The prognostic significance of hemoglobin glycation index (HGI) on acute ischemic stroke (AIS) patients treated with endovascular thrombectomy (EVT) remained unclear. This study aimed to investigate the association between HGI and the risk of poor outcome after EVT.

Methods: We retrospectively enrolled AIS patients with large vessel occlusion in the anterior circulation treated with EVT from a multicenter study.

Association between serum homocysteine concentration level and tooth loss: a cross-sectional study from NHANES 2003-2006.

Introduction: This cross-sectional study aimed to investigate the associations between serum homocysteine levels and missing teeth, as well as to explore the threshold effect of serum homocysteine levels on the number of missing teeth.

Materials And Methods: This study involved 4746 participants (aged ≥ 40 years) from NHANES data 2003-2006. Negative binomial regression was used to assess the association between serum homocysteine levels and tooth loss.

Endoscopic diagnosis of gastric carcinoma of fundic gland type: A case report.

Rationale: Gastric carcinoma of fundic gland type is a new type of gastric cancer with a low incidence rate. The mechanism of gastric carcinoma of the fundic gland differs significantly from that of common adenocarcinoma. While it typically presents as a benign growth, there are cases where it can progress to malignancy.

Interconnecting fragmented forests: Small and mobile birds are cornerstones in the plant-frugivore meta-network.

Habitat fragmentation is causing the collapse of seed dispersal interactions and ecosystem functioning. When management and conservation strategies aim to sustain ecosystem functioning of fragmented forests, species' traits and functional performance are critical in guiding decisions. However, to date, we lack a quantitative understanding of the role of frugivores' body size and dispersal ability in ecosystem sustainability among fragmented forests.

Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) poses challenges in adult patients, considering its heterogeneous nature and often suboptimal treatment outcomes. Here, we performed a study on 201 newly diagnosed adult ALL cases (age ≥ 15 y) to generate intracellular and dynamic serum metabolomic profiles. Our findings revealed a predominant increase in bile acid (BA) metabolites in serum, alongside metabolic rewiring that supported highly proliferative states and actively metabolic signaling, such as enriched nucleotide metabolism in leukemic blasts.

A metabolic fingerprint of ovarian cancer: a novel diagnostic strategy employing plasma EV-based metabolomics and machine learning algorithms.

Ovarian cancer (OC) is the third most common malignant tumor of women and is accompanied by an alteration of systemic metabolism. A liquid biopsy that captures and detects tumor-related biomarkers in body fluids has great potential for OC diagnosis. EVs, nanosized extracellular vesicles found in the blood, have been proposed as promising biomarkers for liquid biopsies.

Nanozyme-Based Strategies against Bone Infection.

Nanozymes are a class of nanomaterials that exhibit catalytic functions analogous to those of natural enzymes. They demonstrate considerable promise in the biomedical field, particularly in the treatment of bone infections, due to their distinctive physicochemical properties and adjustable catalytic activities. Bone infections (e.

Organic Molecular Amino Acids Additives Containing Amide Groups for Uniform Zinc Deposition in Aqueous Zinc Ion Batteries.

Aqueous Zn-metal batteries have been considered as a potentially sustainable energy storage device. They often suffer from poor reversibility and cyclability due to metallic Zn dendrites and parasitic reactions. However, the previous perspectives and mechanisms, coupled with their intricate functional groups for dendrite growth, H evolution, and Zn metal corrosion, render the selection criteria of electrolyte additives inherently ambiguous.

Evaluation and prediction of relapse risk in stable systemic lupus erythematosus patients after glucocorticoid withdrawal (PRESS): an open-label, multicentre, non-inferiority, randomised controlled study in China.

Objectives: To explore the relapse rate after glucocorticoid (GC) withdrawal with or without hydroxychloroquine (HCQ) maintenance in sustained clinically inactive systemic lupus erythematosus (SLE).

Methods: The PRESS trial is a multicentre, 33-week, open-label, three-arm, non-inferiority designed, randomised controlled trial. SLE patients with sustained clinically inactive disease who maintained on low-dose GC plus HCQ therapy were screened and qualified patients were randomly assigned to three groups: drug-free group (both GC and HCQ withdrew); HCQ group (discontinued GC but maintained HCQ); dual maintenance group (both GC and HCQ continued).

Cell-free epigenomes enhanced fragmentomics-based model for early detection of lung cancer.

Background: Lung cancer is a leading cause of cancer mortality, highlighting the need for innovative non-invasive early detection methods. Although cell-free DNA (cfDNA) analysis shows promise, its sensitivity in early-stage lung cancer patients remains a challenge. This study aimed to integrate insights from epigenetic modifications and fragmentomic features of cfDNA using machine learning to develop a more accurate lung cancer detection model.

Preparation of Degradable and Sequence-Controlled Aliphatic Polysulfones by Group Transfer Radical Polymerization.

The incorporation of sulfur atoms into polymer backbones for the synthesis of sulfur-containing polymers, such as aliphatic polysulfones, not only enhances degradability but also imparts many distinctive properties to these materials. Traditional synthetic methods encounter substantial challenges in achieving sequence-controlled aliphatic polysulfones with high molecular weights (MW), which significantly limits their applications. We report a novel approach for synthesizing aliphatic polysulfones using the strategy of sulfonyl radical-mediated group transfer radical polymerization (GTRP).

Multi-dimensional evidence from the UK Biobank shows the impact of diet and macronutrient intake on aging.

Background: The role of diet in aging is crucial, yet research findings on how specific diets influence human aging remain inconsistent. Understanding the relationship between dietary factors and aging could inform interventions to promote healthier aging outcomes.

Methods: We analyzed data from the UK Biobank baseline survey and a 24-hour dietary assessment survey to investigate the association between diet and aging.

Trace Dual-Crosslinkable Additives Enable Direct Microlithography for Enhanced Organic Electrochemical Transistors.

Similar to silicon-based electronics, the implementation of micro/nano-patterning to facilitate complex device architectures and high-density integration is crucial to the development of organic electronics. Among various patterning techniques, direct microlithography (DML) is highly applicable and extensively adopted in organic electronics, such as organic electrochemical transistors (OECTs). However, conventional DML often requires high crosslinker concentrations, leading to compromised electrical performance.

Causal Association Between Chronic Inflammatory Arthropathies and Sarcopenia and the Mediation Role of Inflammatory Factors.

Background: Although chronic inflammatory arthropathies (CIA) are associated with sarcopenia, sarcopenia plays a role in their pathogenesis remains unknown. This study investigated the causal relationship between sarcopenia and CIA and to identify potential mediating factors.

Methods: We examined data from 458 910 participants in the UK Biobank to analyze the association between sarcopenia-related traits and CIA.