Tb-based Metal-Organic Framework-Referenced Fluorescence Assay for Distinguishing Hydroquinone from Its Isomers and Subsequent Quantitative Visual Detection of Cu.

Hydroquinone (HQ) and copper ions (Cu) are categorized as environmental pollutants that are severely limited in water. Designing a selective assay for discriminating HQ from its two isomers and the convenient determination of Cu is of great importance. Herein, a Tb-based metal-organic framework (Tb-MOF) and HQ are assembled innovatively into a ratiometric fluorescence nanoprobe to selectively distinguish HQ and subsequent quantitative visual detection of Cu.

Targeted Theranostic Nanoprobes Assisted NIR-II Fluorescence Imaging-Guided Surgery Therapy for Alveolar Echinococcosis.

Alveolar echinococcosis (AE) is a serious parasitic infectious disease that is highly invasive and destructive to the liver and has a high mortality rate. However, currently, there is no effective targeted imaging and treatment method for the precise detection and therapy of AE. We proposed a new two-step targeting strategy (TSTS) for AE based on poly(lactic--glycolic acid) (PLGA).

The mosquito evolves two types of prophenoloxidases with diversified functions.

Insect phenoloxidase, presented as an inactive precursor prophenoloxidase (PPO) in hemolymph, catalyzes melanin formation, which is involved in wound healing, pathogen killing, reversible oxygen collection during insect respiration, and cuticle and eggshell formation. Mosquitoes possess 9 to 16 PPO members across different genera, a number that is more than that found in other dipteran insects. However, the reasons for the redundancy of these PPOs and whether they have distinct biochemical properties and physiological functions remain unclear.

Molecular and clinical traits of HER2-low breast cancer patients and their relationship with neoadjuvant treatment effectiveness.

Background: We aimed to investigate the clinical and molecular characteristics of different degrees of human epidermal growth factor receptor 2 (HER2) protein expression in HER2-negative breast cancer and the related factors affecting the efficacy of neoadjuvant chemotherapy in HER2-low breast cancer patients.

Methods: The study endpoint was pathological complete remission (PCR). Blood specimens and fresh cancer tissue samples were collected before neoadjuvant chemotherapy for whole-exon sequencing (WES) and RNA sequencing (RNA-seq), and patients were divided into a human epidermal growth factor receptor 2 (HER2)-low group and a HER2-0 group according to their HER2 expression status via bioinformatics analysis.

A prediction method and evaluation for assessing guide-supported dental implant accuracy.

Functional and esthetic results require accurate implant placement. We aimed to develop a predictive method for assessing dental implant accuracy, and to evaluate the cumulative system influence of surgical guides. A mathematical model was constructed to determine the influence of surface changes on a specific point, using Jacobian matrix expressions.

Unusual Iron-Independent Ferroptosis-like Cell Death Induced by Photoactivation of a Typical Iridium Complex for Hypoxia Photodynamic Therapy.

Ferroptosis is a unique cell death mode that relies on iron and lipid peroxidation (LPO) and is extensively utilized to treat drug-resistant tumor. However, like the other antitumor model, requirement of oxygen limited its application in treating the malignant tumors in anaerobic environments, just as photodynamic therapy, a very promising anticancer therapy. Here, we show that an iridium(III) complex (Ir-dF), which was often used in proton-coupled electron transport (PCET) process, can induce efficient cell death upon photo irradiation, which can be effectively protected by the typical ferroptosis inhibitor Fer-1 but not by the classic iron chelating agents and ROS scavengers.

Citrobacter rodentium promotes brain cognitive dysfunction of type 2 diabetes mice by activating FXR mediated gut barrier damage.

Type 2 diabetes (T2D) is an important risk factor for brain cognitive impairment, but the specific mechanism is still unclear. The imbalance of gut microbiota under pathological conditions (such as an increase in pathogenic bacteria) may be involved in the occurrence of various diseases. The purpose of this study is to investigate the effect of increased abundance of gut Citrobacter rodentium on cognitive function in T2D mice.

Narciclasine attenuates sepsis-associated acute kidney injury through the ESR1/S100A11 axis.

Narciclasine (Ncs) was effective in sepsis management due to its antioxidant properties. The present study dissected the protective effects of Ncs against sepsis-associated acute kidney injury (SA-AKI) and the molecular mechanisms. The SA-AKI mice were developed using cecum ligation and puncture and pretreated with Ncs and adenoviruses.

Development and validation of a preoperative nomogram for predicting gallbladder adenoma.

Background: Gallbladder cholesterol polyp (GCP) and gallbladder adenoma (GA) are easily confused in clinical diagnosis. This study aims to establish a nomogram prediction model for preoperative prediction of the risk of GA patients.

Study Design: We retrospectively collected clinical data of GCP or GA patients who underwent laparoscopic cholecystectomy (LC) between January 2020 and April 2023.

Epigenetics in the modern era of crop improvements.

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades, our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits.

Organocatalytic Asymmetric Synthesis of -Carboranyl Amines.

Carboranyl amines are distinct from typical organic amines. Due to the electronic influence of the carborane cage, they have low nucleophilicity and are reluctant to alkylate. Moreover, asymmetric synthesis of chiral carboranes is still in its infancy.

A mouse coccygeal intervertebral disc degeneration model with tail-looping constructed using a suturing method.

Backgroud: Intervertebral disc degeneration (IDD) is one of the common degenerative diseases. Due to ethical constraints, it is difficult to obtain sufficient research on humans, so the use of an animal model of IDD is very important to clarify the pathogenesis and treatment mechanism of the disease.

Methods: In this study, thirty 2-month-old mice were selected for operation to establish a coccygeal IDD model.

Continuous Costoclavicular Brachial Plexus Block for Humeral Fractures in Pregnancy: A Case Report and Literature Review.

Brachial plexus block is the predominant anesthetic method used for upper-limb surgical procedures in pregnant patients. The innovative method of brachial plexus block in the costoclavicular space has shown enhanced reliability and effectiveness for postoperative analgesia. We report a case of a pregnant woman who underwent surgery for a humeral fracture.

Bis(dialkylaminethiocarbonyl)disulfides Act as Electron Acceptors for EDA Complexes for the Synthesis of Dithiocarbamate Derivatives under Visible Light.

This study proposes a green and efficient atom- and step-economical method for converting hazardous CS to dithiocarbamate derivatives under visible light irradiation and catalyst-free conditions. By the construction of novel C-S and C-N bonds, a series of β-dicarbonyl compounds and amines are incorporated into the products. Under light, CS and amine first form bis(dialkylaminethiocarbonyl)disulfides, which then react with KCO-activated β-dicarbonyl compounds to form electron donor-acceptor (EDA) complexes and subsequently generate the target products.

Near-complete genome sequence of a type-A deformed wing virus discovered from in Mississippi, USA.

Deformed wing virus (DWV) can cause a major disease in honeybees worldwide and has been detected in many other arthropods (S. J. Martin and L.

Influence of the neck length of urease-powered flask-like colloidal motors on their kinematic behavior.

Enzyme-powered synthetic colloidal motors hold promising potential for medical applications because of their unique features such as self-propulsion, sub-micrometer size, fuel bioavailability, and structural and functional versatility. However, the key parameters influencing the propulsion efficiency of enzyme-powered colloidal motors still remain unclear. Here, we report the effect of the neck length of urease-powered pentosan flask-like colloidal motors on their kinematic behavior resembling the role of bacterial flagella.

Highly Tension-Strained Copper Concentrates Diluted Cations for Selective Proton-Exchange Membrane CO2 Electrolysis.

Electrolysis of carbon dioxide (CO2) in acid offers a promising route to overcome CO2 loss in alkaline and neutral electrolytes, but requires concentrated alkali cations (typical ≥3 M) to mitigate the trade-off between low pH and high hydrogen evolution reaction (HER) rate, causing salt precipitation. Here we report a strategy to resolve this problem by introducing tensile strain in a copper (Cu) catalyst, which can selectively reduce CO2 to valuable multicarbon products, particularly ethylene, in a pH 1 electrolyte with 1 M potassium ions. We find that the tension-strained Cu creates an electron-rich surface that concentrates diluted potassium ions, contributing to CO2 activation and HER suppression.

Graphene quantum dot-modified CoO/NiCoO yolk-shell polyhedrons as a polysulfide-adsorptive sulfur host for lithium-sulfur batteries.

The shuttle effect of lithium polysulfides and non-ideal reaction kinetics restrict the development of high-energy-density lithium-sulfur (Li-S) batteries. Here, we report a graphene quantum dot (GQD)-modified CoO/NiCoO yolk-shell polyhedron as a sulfur host for Li-S batteries. GQDs shorten transport pathways of electrons, while strong binding of CoO and NiCoO to LiS, LiS and LiS are demonstrated from density functional theory calculations.

Proteomics unveil candidate biomarkers and pathogenesis of subacute thyroiditis.

Subacute thyroiditis (SAT) is an inflammatory thyroid disease characterized by neck pain, tenderness, general symptoms, and thyroid dysfunction. Despite gaining new insights into the epidemiology, pathogenesis, and treatment of SAT in recent years, the exact pathogenesis and determinants of its clinical progression remain unclear. Here, we profiled thyroid in situ protein alterations in fine needle aspiration biopsy samples from SAT patients using proteomic analysis and uncovered 57 differentially abundant proteins.

Predicting delayed neurological sequelae in patients with carbon monoxide poisoning using machine learning models.

Introduction: Delayed neurological sequelae is a common complication following carbon monoxide poisoning, which significantly affects the quality of life of patients with the condition. We aimed to develop a machine learning-based prediction model to predict the frequency of delayed neurological sequelae in patients with carbon monoxide poisoning.

Methods: A single-center retrospective analysis was conducted in an emergency department from January 01, 2018, to December 31, 2023.

Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's-related phenotypes.

Introduction: Interferon-induced transmembrane protein 3 (IFITM3) modulates γ-secretase in Alzheimer's Disease (AD). Although IFITM3 knockout reduces amyloid β protein (Aβ) production, its cell-specific effect on AD remains unclear.

Methods: Single nucleus RNA sequencing (snRNA-seq) was used to assess IFITM3 expression.

Lignan-phloroglucinol hybrids with an unprecedented beadlike core from the leaves of .

(±)-Melichuniiones A and B (1 and 2), two novel enantiomeric pairs of lignan-phloroglucinol hybrids with an unprecedented beadlike core were isolated from the leaves of , together with new analogues 3-6. Compounds 1 and 2 possess a unique dispiro [furan-2,5'-cyclopenta[]furan-2',3''-furan] 5/5/5/5 tetracyclic skeleton. Their structures were established by extensive spectroscopic analyses, single crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations.

Validation Status of Electronic Sphygmomanometers in China: A National Survey.

Background: Although the information on the validation status of electronic sphygmomanometer (ES) devices in use in health care institutions and households is much more clinically relevant than that of ES models available on the market, it remains insufficient.

Methods: A national survey was conducted across all administrative regions of mainland China to assess the validation status of ESs. Fifty-eight cities were selected with stratification by municipality, provincial capital, and other cities, and health care institutions and households in each city were chosen by convenience to identify ES devices in use according to the study protocol.

Reductive Removal of Antimony from Wastewater by a UV/Sulfite Process: Targeted Recovery of Strategic Metalloid Antimony.

The removal of antimony from wastewater using traditional methods such as adsorption and membrane filtration generates large amounts of antimony-containing hazardous wastes, posing significant environmental threats. This study proposed a new treatment strategy to reductively remove and recover antimony from wastewater using an advanced UV/sulfite reduction process in the form of valuable strategic metalloid antimony (Sb(0)), thus preventing hazardous waste generation. The results indicated that more than 99.

Molecular Mechanisms of Humic Acid in Inhibiting Silica Scaling during Membrane Distillation.

Membrane distillation (MD) efficiently desalinizes and treats high-salinity water as well as addresses the challenges in handling concentrated brines and wastewater. However, silica scaling impeded the effectiveness of MD for treating hypersaline water and wastewater. Herein, the effects of humic acid (HA) on silica scaling behavior during MD are systematically investigated.