Disordered Expression of , the Gene Encoding a Serine-Threonine Protein Kinase GSK3, Affects the Lifespan in a Transcript-, Stage-, and Tissue-Specific Manner.

GSK3 (glycogen synthase kinase 3) is a conserved protein kinase governing numerous regulatory pathways. In , GSK3 is encoded by (), which forms 17 annotated transcripts corresponding to 10 protein isoforms. Our goal was to demonstrate how differential transcription affects lifespan, which GSK3 isoforms are important for the nervous system, and which changes in the nervous system accompany accelerated aging.

Dynamics of Structural Parameters and Accumulation of Collagen Fibrils in Rat Lung after Inhalations of Surfactant-BL at Various Terms of Bleomycin-Induced Alveolitis.

Rats were subjected to surfactant-BL inhalations at the early and late phases of bleomycininduced alveolitis. In both regimens, the drug reduced the severity of inflammation. In the acute phase of alveolitis, the therapeutic effect of inhalation was accompanied by activation of the synthesis of fine lose collagen fibrils.

[Characteristics of allergic diseases in children in unfavorable ecologic situation of Komi Republic].

Ecologic situation in Komi Republic is heterogenous. Examination covered 207 children aged 6 months to 16 years, having allergic diseases, in Ukhta, Komi Republic. Findings are correlations between allergy symptoms, severity and increased xenobiotics load.

Quantitative two-process analysis of avoidance conditioning in goldfish.

The shuttlebox performance of goldfish was studied under standardized conditions in a variety of problems--with or without an avoidance contingency, a conditioned stimulus (CS)-termination contingency, and an escape contingency. The effects of CS-only, unconditioned stimulus (US)-only, and explicitly unpaired training were also examined. All the data could be simulated quantitatively with a version of O.

[Relation between the learning of young rainbow trout in a shuttle-box and survival in the presence of an unfamiliar predator].

The analysis of the curves of acquisition of a conditioned reflex (CR) in a shuttle box allowed to reveal three stages of this process and establish in two-year rainbow trouts the presence of four types of individuals differing in the dynamics of processes of the CR formation. A direct positive connection is established between the speed of learning in a shuttle box and surviving of young fish in the presence of artificial predator.

[Mechanisms of increasing the intensity of ultraviolet fluorescence of irradiated cells].

As shown on the in vitro irradiated Ehrlich ascites tumor cells the increase in the intensity of ultraviolet fluorescence (UVF) of the exposed cells occurs only in such incubation conditions when an increase in the tryptophan content of irradiated cells becomes possible. The increase in the UVF intensity and in the tryptophan content are quantitatively identical. It is concluded that the increase in the content of the fluorescing substance, tryptophan, in the irradiated cells is the cause of the increase in the UVF intensity.