Relationship Between Antiinflammatory Cytokine Interleukin-10 and Lactate Concentrations in Neonates Undergoing the Arterial Switch Operation.

Background: The aim of this study was to evaluate the relationship between antiinflammatory cytokine interleukin (IL)-10 production and perioperative lactate concentrations and their impact on postoperative outcomes in neonates undergoing the arterial switch operation (ASO).

Methods: Between August 2010 and August 2012, 80 neonates with transposition of the great arteries (TGA) were enrolled. Serum IL-10 levels were measured immediately before and after cardiopulmonary bypass (CPB) on the first, third, and seventh days.

[IMPACT OF PERINATAL TACTICS ON THE POSTOPERATIVE PERIOD COURSE IN SURGICAL ELIMINATION OF AORTAL COARCTATION IN NEWBORN BABIES].

The results of perinatal management and surgical treatment of 30 newborn babies, owing antenatally diagnosed isolated aortal coarctation (AC) and 40 newborn babies, in whom this diagnosis was not established antenatally, were analyzed. Application of antenatal diagnosis and optimization of the patients' perinatal management algorithm have permitted to reduce the treatment duration in the intensive therapy division of cardiosurgical department. In newborn babies, to whom the diagnosis of AC was established antenatally, a trustworthy reduced duration of postoperative pulmonary artificial ventilation was revealed in comparison with such in patients, in whom this diagnosis was not established antenatally.

Morphological characteristics of cultured fresh and thawed pericardium cells.

The need for selection of the optimal material for the manufacturing of cardio-patches can be resolved by the use of cryostored autologous pericardial tissue. This short communication is a concise fragment of a large-scale research and demonstrates only the efficiency of cell culturing before and after pericardial preservation in the low temperature conditions.

[Antibodies to Hsp60 in newborn babies, to whom during the intervention for critical inborn heart failure, autologous cord blood was transfused, in early and late postoperative period].

The titre of antibodies to Hsp60 (heat shock protein) enhancement in the blood serum is considered a biological marker of poor state of organism. Comparative investigation was done on the antibodies titre to Hsp60 in the blood serum of a newborn babies, suffering critical inborn heart failure, to whom autologous cord blood or the donor's blood components was transfused, in early and remote postoperative period. In early postoperative period the lowering of the antibodies titre to Hsp60 in the blood serum was observed in comparison with them preoperatively, in a late period (in 2 yrs) in all the blood serum samples investigated antibodies to Hsp60 were not revealed.

Tissue perfusion in neonates undergoing open-heart surgery using autologous umbilical cord blood or donor blood components.

Background: This study evaluates the hemoglobin-oxygen relationship and tissue perfusion during cardiopulmonary bypass (CPB) in neonates undergoing open-heart surgery using autologous umbilical cord blood or donor blood components.

Methods: We compared perioperative hematocrit (Hct), fetal hemoglobin (HbF), p(50)O(2), pH, pCO(2), serum lactate, duration of mechanical ventilation and intensive care unit (ICU) length of stay in neonates undergoing open-heart surgery using autologous umbilical cord blood (Group I, N=45) or donor blood components (Group II, N=65). The groups were similar with respect to diagnosis, weight, type of procedure, duration of CPB and duration of myocardial ischemia.

Doxorubicin dose for congestive heart failure modeling and the use of general ultrasound equipment for evaluation in rats. Longitudinal in vivo study.

Introduction: For the evaluation of the congestive heart failure (CHF) in rat models, the use of special equipment for echocardiography for dynamic evaluation is suggested. The optimal doxorubicin dose for CHF induction has still not been established.

Aims: The aims of our study was to find a reliable doxorubicin CHF rat model using a general ultrasound (US) equipment for in vivo ultrasound examination of the systemic circulation, to establish the optimal doxorubicin dose, and to assess the feasibility of US guided administration of the drug.

[The influence of autologous umbilical cord blood and donor blood on cytokine profile of newborns with transposition of great vessels].

We investigated the serum levels ofproinflammatory and antiinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10) in newborns with transposition of the great arteries to whom during the defect correction the autologous umbilical cord blood and blood components were administered before the surgery and at the 1st, 3rd, 7th day after the surgery. We found that in the group of newborns to whom during the operation the blood components were used, the levels ofpro-inflammatory interleukins were high before surgery and at the Ist, 3rd and 7th day after it, but IL-10 was reduced. During the postoperative period, the newborns of this group had imbalance in the system cytokine, accompanied by clinical complications such as hyperthermia and pulmonary complications.

Arterial switch operation in the first hours of life using autologous umbilical cord blood.

Background: In this study, we analyzed our clinical experience performing the arterial switch operation in the first hours of life using autologous umbilical cord blood transfusion (AUCBT). The safety and efficiency of AUCBT was assessed and compared with surgery with the use of homologous blood transfusion.

Methods: Between September 2009 and February 2011, 61 neonates underwent ASO at our institution.

[Arterial switching operation in the first hours of life of newborn babies with transposition of the main vessels diagnosed prenatally].

A global tendency of enhancement of a prenatal diagnosis establishment rate in critical inborn heart failures demands to overestimate the existing surgical strategy. Taking into account a present sufficient compensation of a newborn babies state, suffering main vessels transposition, in first hours of the patients life and existing possibility to approve a surgical tactics before the patient's birth after the prenatal diagnosis establishment, we have proposed an innovative approach, consisting of conduction of the arterial switching operation without preliminary performance of the balloon atrioseptostomy and preoperative medicinal therapy. The efficacy and security of a new approach were analyzed.

Open cardiac surgery in the first hours of life using autologous umbilical cord blood.

Objective: This article describes the first clinical experience of complete repair of complex critical congenital heart diseases (CHDs) in the first hours of life using autologous umbilical cord blood (UCB). Prenatal diagnosis and harvesting of autologous UCB allow to modify perioperative management and to perform corrective surgery in the first hours of a patient's life. This approach can afford avoiding homologous blood transfusion and preventing development of hypoxemia and heart failure due to hemodynamic changes of complex critical CHD.

[Early extubation of children in the the first year of life with inborn heart failure after surgery, performed with artificial blood circulation].

The possibility of early extubation of the first year of life children after surgical correction of congenital heart diseases while artificial blood circulation conduction was studied. For the 1996-1999 period surgical treatment was conducted in 381 patients aged at average (5.71 +/- 3.

[The experience of application of peritoneal dialysis in cardiosurgery of an early age children].

The experience of the peritoneal dialysis (PD) successful application in 16 children of an early age was summarized. In all the patients the terminal state with an acute cardiac and renal insufficiency was noted after cardiosurgical operation conduction using artificial blood circulation. The improvement of hemodynamical indices, renal and pulmonary function as well, were promoted by an early application of PD.

[The surgical treatment of aortic coarctation in infants in the 1st year of life with significantly decreased contractile function of the left ventricle].

During the 1991-1998 yrs period there were operated on 20 patients with coarctation of aorta (CoA), aged up to 1 year old, in whom the ejaculatory fraction (EF) of left ventriculus (LI) was not exceeding 40%. All the patients were admitted to the hospital in the severe state of health, the end-diastolic (EDI) and the end-systolic (ESI) index constituting accordingly (144.2 +/- 47.