BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype.

Unlabelled: RUNX2 expression in mesenchymal cells induces osteoblast differentiation and bone formation. BMP blocking agents were used to show that RUNX2-dependent osteoblast differentiation and transactivation activity both require BMP signaling and, further, that RUNX2 enhances the responsiveness of cells to BMPs.

Introduction: BMPs and the RUNX2 transcription factor are both able to stimulate osteoblast differentiation and bone formation.