Publications by authors named "Zhou-Ming Wu"
AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation.
Signal Transduct Target Ther
October 2024
Article Synopsis
- AXIN1 is a crucial scaffold protein that regulates cell fate and plays a significant role in antiviral immunity against both DNA and RNA viruses.
- It stabilizes the transcription factor IRF3 by preventing its degradation and increases IRF3 phosphorylation during viral infections, enhancing the production of interferon.
- The small molecule KYA1797K improves AXIN1 and IRF3 interactions, potentially serving as an effective antiviral treatment, with reduced AXIN1 levels linked to poorer survival rates in HBV-associated liver cancer patients.
The techniques and outcomes of in situ replantation are discussed for managing 5 cases of articular composite tissue masses severed from an extremity (digit). All 5 cases treated with in situ replantation survived. Rehabilitation was performed after surgery.
View Article and Find Full Text PDF