Publications by authors named "Zhou-Ai Wang"
Article Synopsis
- Anterior lumbar interbody fusion (ALIF) utilizes broad-footprint interbody cages and increasingly incorporates bone graft substitutes to enhance fusion rates and reduce postoperative issues related to autologous bone grafts.
- A systematic review analyzed recent literature from 2012 to 2023, focusing on fusion efficacy and complications associated with these substitutes, particularly recombinant human bone morphogenetic protein-2 (rhBMP-2), which showed high fusion rates but also potential for increased complications.
- Findings reveal inconsistency in methodologies for assessing fusion and complications across studies, indicating a need for standardized evaluation criteria to improve research reliability and comparability.
Time of day differences in the regulation of glutathione levels in the rat lens.
Front Ophthalmol (Lausanne)
August 2024
Introduction: Evidence in non-ocular tissues indicate that the antioxidant glutathione (GSH) may be regulated in a circadian manner leading to the idea that GSH levels in the lens may also be controlled in a circadian manner to anticipate periods of oxidative stress.
Methods: Male rat Wistar lenses (6 weeks) were collected every 4 hours over a 24-hour period at 6am, 10am, 2pm, 6pm, 10pm and 2am and quantitative-PCR, western blotting and immunohistochemistry performed to examine the expression of core clock genes and proteins (BMAL1, CLOCK, CRY1-2, PER 1-3) and their subcellular localisation over a 24-hour period. Western blotting of lenses was also performed to examine the expression of NRF2, a transcription factor involved in regulating genes involved in GSH homeostasis and GSH related enzymes (GCLC, GS and GR) over the 24-hour period.