An insulator target detection algorithm based on improved YOLOv5.

Drone inspections are widely utilized in the detection of insulators in power lines. To address issues with traditional object detection algorithms, such as large parameter counts, low detection accuracy, and high miss rates, this paper proposes an insulator detection algorithm based on an improved YOLOv5 model. Firstly, in the backbone and neck networks, a lightweight CSP-SCConv module is employed to replace the original CSP-Darknet53 module, thereby reducing the parameter count and enhancing the feature extraction capabilities.

Wide field of view large aperture meta-doublet eyepiece.

Wide field of view and light weight optics are critical for advanced eyewear, with applications in augmented/virtual reality and night vision. Conventional refractive lenses are often stacked to correct aberrations at a wide field of view, leading to limited performance and increased size and weight. In particular, simultaneously achieving a wide field of view and large aperture for light collection is desirable but challenging to realize in a compact form-factor.

Chronic unpredictable stress induces anxiety-like behavior and oxidative stress, leading to diminished ovarian reserve.

Chronic stress can adversely affect the female reproductive endocrine system, potentially leading to disorders and impairments in ovarian function. However, current research lacks comprehensive understanding regarding the biochemical characteristics and underlying mechanisms of ovarian damage induced by chronic stress. We established a stable chronic unpredictable stress (CUS)-induced diminished ovarian reserve (DOR) animal model.

MFC-ACL: Multi-view fusion clustering with attentive contrastive learning.

Multi-view clustering can better handle high-dimensional data by combining information from multiple views, which is important in big data mining. However, the existing models which simply perform feature fusion after feature extraction for individual views, mostly fails to capture the holistic attribute information of multi-view data due to ignoring the significant disparities among views, which seriously affects the performance of multi-view clustering. In this paper, inspired by the attention mechanism, an approach called Multi-View Fusion Clustering with Attentive Contrastive Learning (MFC-ACL) is proposed to tackle these issues.

Kif15 regulates Coro1a cell migration and phagocytosis in zebrafish after spinal cord injury.

The role of immune cells is crucial in nerve regeneration following spinal cord injury. Kif15, a member of the kinesin family, has been shown to enhance macrophage phagocytosis. This study investigates the impact of Kif15 deficiency on immune cells in zebrafish with spinal cord injury.

Fully Integrated Passive Wireless Sensor with Mechanical-Electrical Double-Gradient for Multifunctional Healthcare Monitoring.

Accurate, effective, and continuous monitoring of pressure, moisture, and temperature is essential for routine health assessments and professional patient care. In this study, we present a fully integrated multiparameter passive wireless sensor (MWS) that employs a mechanical-electrical dual-gradient structure design. The unique gradient porous structure endows the MWS with significant advantages in terms of detection dimensions (pressure, moisture, and temperature), sensitivity, and stability.

ScRNA-seq and bulk RNA-seq identified NUPR1 as novel biomarkers related to CD4 + T cells infiltration for abdominal aortic aneurysm.

Background: Developing a molecular signature associated with CD4 + T cell infiltration is essential for identifying biomarkers in abdominal aortic aneurysms (AAA). Establishing such a signature is vital for improving diagnostic accuracy and therapeutic strategies for AAA. This study focuses on CD4 + T cells, which are pivotal in the immune microenvironment of AAA, to pinpoint key targets.

mA RNA methyltransferase METTL16 induces Cr(VI) carcinogenesis and lung cancer development through glutamine biosynthesis and GLUL expression.

Hexavalent chromium [Cr(VI)] exposure increases the risk of cancer occurrence. This study found that the levels of an atypical methyltransferase, METTL16 were greatly upregulated in the cells, and mouse tissues with Cr(VI) exposure, and played a critical role in cell proliferation and tumor growth induced by Cr(VI). Similarly, we found METTL16 was upregulated in various human cancer tissues.

Wearable Pendulum-Rotor-Separated Hybrid Generator for Smart Healthcare Monitoring.

Human biomechanical energy, with features of fluctuating amplitudes and low frequency, has been considered as a potential sustainable power source for wearable healthcare monitoring devices. Developing an effective energy harvester to ensure robust energy harvesting efficiency remains highly desired. Herein, we propose a wearable pendulum-rotor-separated triboelectric-electromagnetic hybrid generator (PTEHG).

Research on Lightweight Method of Insulator Target Detection Based on Improved SSD.

Aiming at the problems of a large volume, slow processing speed, and difficult deployment in the edge terminal, this paper proposes a lightweight insulator detection algorithm based on an improved SSD. Firstly, the original feature extraction network VGG-16 is replaced by a lightweight Ghost Module network to initially achieve the lightweight model. A Feature Pyramid structure and Feature Pyramid Network (FPN+PAN) are integrated into the Neck part and a Simplified Spatial Pyramid Pooling Fast (SimSPPF) module is introduced to realize the integration of local features and global features.

Screening of oxytetracycline-degrading strains in the intestine of the black soldier fly larvae and their degradation characteristics.

The presence of excessive antibiotic residues poses a significant threat to human health and the environment. This study was designed to identify an effective oxytetracycline (OTC)-degrading strain through the screening of the intestine of black soldier fly larvae (BSFL). A strain designated "B2" was selected using a series of traditional microbial screening methods.

Nonlinear upconverted thermal emission through difference frequency generation.

Thermal radiation management is of critical importance in energy, sensing, and heat transfer. According to Planck's law, objects at room temperature predominantly emit thermal radiation within the mid- and far-infrared bands. Here, we demonstrated the upconversion of the mid- and far-infrared thermal radiation emitted by second-order nonlinear material to the easily-detectable visible band through a difference frequency process.

Gut Microbiota Disorder Contributes to the Production of IL-17A That Exerts Chemotaxis via Binding to IL-17RA in Endometriosis.

Introduction: Endometriosis (EM) is a chronic estrogen-dependent condition characterized by the growth of endometrial-like tissue outside the uterus, posing a significant burden on reproductive-aged women. Previous research has shown a correlation between gut microbiota dysbiosis and interleukin-17A (IL-17A) in EM patients. IL-17A, a promising immunomodulatory molecule, exerts dual roles in human physiology, driving inflammatory diseases.

Upregulation of NPC1 and its association with poor prognosis in gastric cancer.

Background: The Niemann-Pick disease type C1 (NPC1) protein plays a pivotal role in lipid transport, particularly free cholesterol, within lysosomal/late endosomal membranes. Previous studies have highlighted NPC1 as a promising target for cholesterol trafficking and cancer therapy. Nevertheless, the expression of NPC1 in gastric cancer (GC) and its clinical implications remain unexplored.

MEF2C contributes to axonal branching by regulating Kif2c transcription.

Neurons are post-mitotic cells, with microtubules playing crucial roles in axonal transport and growth. Kinesin family member 2c (KIF2C), a member of the Kinesin-13 family, possesses the ability to depolymerize microtubules and is involved in remodelling the microtubule lattice. Myocyte enhancer factor 2c (MEF2C) was initially identified as a regulator of muscle differentiation but has recently been associated with neurological abnormalities such as severe cognitive impairment, stereotyping, epilepsy and brain malformations when mutated or deleted.

Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality.

Aim: In 2019, to examine the functions of METTL3 in liver and underlying mechanisms, we generated mice with hepatocyte-specific METTL3 homozygous knockout (METTL3Δhep) by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT) or Alb-Cre mice (JAX), respectively. In this study, we explored the potential reasons why hepatocyte-specific METTL3 homozygous disruption by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and then postnatal lethality.

Main Methods: Mice with hepatocyte-specific METTL3 knockout were generated by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT; Strain No.