A wireless sensor for nanosecond transient electric field measurement based on asymptotic conical antenna and high-speed data acquisition technology.

The transient electromagnetic field generated by the operation of high-voltage switches in substations can cause electromagnetic interference to the communication and control electronic equipment in the substation. On the other hand, it can also reflect the working status of the high-voltage switch itself. Therefore, it is necessary to measure and study it.

Bacterial Spore Inactivation Technology in Solid Foods: A Review.

In response to physiological stress, some bacterial strains have the ability to produce spores that are able to resist conventional food heating processes and even more extreme environmental factors. Dormant spores can germinate and return to their vegetative state during food preservation, leading to food spoilage, or safety issues that pose a risk to human health. Thus, spore inactivation technology is gaining more and more attention.

A multifunctional semi-interpenetrating polymer network hydrogel dressing for wound healing.

Hydrogels have exhibited significant application potential in the field of new wound dressings due to their unique physicochemical properties and biological functions. However, traditional hydrogels possess limitations regarding mechanical properties, adhesion, and the promotion of wound healing. Herein, a multifunctional polyvinyl alcohol-tannic acid/polyacrylamide-polydopamine (PVA-TA/PAM-PDA) hydrogels are developed.

Effect of driving pressure-guided individualised positive end-expiratory pressure on postoperative atelectasis in patients with morbid obesity: study protocol of a randomised controlled trial.

Introduction: Atelectasis is a common postoperative complication in patients with obesity, contributing to respiratory insufficiency, pneumonia and poor clinical outcomes. Studies have shown that driving pressure (DP)-guided individualised positive end-expiratory pressure can improve respiratory mechanics and oxygenation, while also reducing the incidence of atelectasis and other postoperative pulmonary complications (PPCs). However, the effect of this ventilation strategy on patients with morbid obesity remains unclear.

Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co-Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma.

Apart from the blood-brain barrier (BBB), the efficacy of immunotherapy for glioblastoma (GBM) is limited by the presence of intrinsic and adaptive immune resistance, implying that co-delivery of various immunotherapeutic agents or simultaneous regulation of different cells is urgently needed. Bacterial outer membrane vesicles (OMVs) offer a unique advantage in the treatment of GBM, owing to their multifunctional properties as carriers and immune adjuvants and their ability to cross the BBB. However, traditional OMVs can lead to toxic side effects and disruption of tight junctions in the BBB.

Develop a prognostic and drug therapy efficacy prediction model for hepatocellular carcinoma based on telomere maintenance-associated genes.

Background: Hepatocellular carcinoma (HCC) poses a substantial global health challenge because of its grim prognosis and limited therapeutic options. Telomere maintenance mechanisms (TMM) significantly influence cancer progression, yet their prognostic value in HCC remains largely unexamined. This research aims to establish a telomere maintenance-associated genes(TMGs)-based prognostic model using transcriptomic and clinical data to evaluate its effectiveness in predicting patient outcomes in HCC.

FERMT2 drives anoikis resistance and peritoneal metastasis by enhancing extracellular matrix deposition in gastric cancer.

Peritoneal metastasis is a critical step in the progression of gastric cancer (GC), yet its underlying mechanisms remain poorly understood. Here, we identify FERMT2, a member of the Kindlin protein family, as a key regulator of anoikis resistance (AR) and peritoneal metastasis in GC. FERMT2 expression increases in a suspension-time-dependent manner and is associated with higher pathological grade, advanced clinical stage, and poorer prognosis.

Molecular mechanistic insights towards aggregation of nano-biochar moderated by aromatic components in dissolved organic matter.

Nano-biochar (NBC) is a promising tool for sustainable remediation of contaminants in aquatic environments. However, the presence of ubiquitous ions and dissolved organic matter (DOM) can impact NBC aggregation, resulting in reduced application efficacy and potential ecological risks. Understanding and regulating NBC aggregation offers valuable insights for its deployment.

Lipid pro-oxidative reactions mediated by heat, light and microwave and the structural characteristics of their products: Revealed via multi-omics approaches.

Heat, light, and microwave treatments differentially modulate food flavor profiles through lipid oxidation, but the mechanistic distinctions remain unclear. This study monitored and compared lipid molecular species and flavor compounds in salmon oil processed by these methods via multi-omics technology. Thermal treatment yielded the highest concentrations of alkanes, alkenals, enols, and aldehydes (50.

Highly Strained Electron-Rich Molecular Bowl and Nanographene.

Introducing two pyrrole rings at the armchair edges of perylene creates the small, electron-rich molecular bowl 1, which can be viewed as a nitrogen-doped end-cap of C. Despite numerous attempts since 2008, its synthesis has been hindered by strain and synthetic challenges. In this study, we present the synthesis and property analysis of molecular bowl 1 and its dimer, the wavy-shaped nanographene 2.

A Methionine Allocation Nanoregulator for the Suppression of Cancer Stem Cells and Support to the Immune Cells by Epigenetic Regulation.

Epigenetic dysregulation is prevalent in human cancers, affecting gene expression and metabolic patterns to meet the demands of malignant evolution and abnormal epigenetic processes, and resulting in a protumor immune microenvironment. Tumors require a steady supply of methionine for maintaining epigenetic flexibility, which is the only exogenous precursor of methyl donor S-adenosylmethionine for methylation, crucial for their resistance to therapies and survival in a nutrient-deficient microenvironment. Thus, tumor cells upregulate the Lat4 transporter to compete and deprive methionine in the microenvironment, sustaining their malignant phenotypes and also impairing immune cell functions.

Association between surrogate indices of fatty liver and the risk of colorectal cancer: a cross-sectional United States study.

Background: The presence of fatty liver (FL) has been suggested to influence the incidence of colorectal cancer (CRC). This study aimed to evaluate the predictive utility of six alternative indices of FL-namely, liver fat percentage (PLF), lipid accumulation product (LAP), hepatic steatosis index (HSI), United States fatty liver index (USFLI), fatty liver index (FLI), and Zhejiang University index (ZJU)-in assessing the risk of CRC. We aimed to determine their effectiveness in predicting CRC risk by comparing these surrogate indices.

Pilot randomized controlled trial of extracorporeal shock wave therapy for temporomandibular joint disorders.

Background: Temporomandibular joint disorders (TMDs) are collective terms for a series of clinical diseases. However, due to the complexity of the temporomandibular joint (TMJ), TMDs are still unknown as to their pathogenesis.

Objective: This pilot randomized controlled trial aimed to evaluate the efficacy of extracorporeal shock wave therapy (ESWT) in conjunction with drug therapy for myogenic TMDs

Methods: In accordance with the CONSORT (Consolidated Standards of Reporting Trials) guidelines, we conducted a randomized controlled trial involving 60 patients diagnosed with myogenic TMDs.

Validation of DNA methylation and transcriptional characteristics in CCL5 and CXCL8 genes in autoimmune thyroiditis with varying iodine levels.

AIT (autoimmune thyroiditis) is a complex disease influenced by genetic and environmental factors as well as immune dysregulation. Epigenetics has unveiled potential connections among environmental factors, gene expression and thyroid autoimmunity. Among epigenetic modifications, DNA methylation is the first discovered and the most extensively-studied.

DNA methylation of genes that mediate autophagosome formation contributes to iodine-induced autoimmune thyroiditis: A population-based study conducted at regions with different iodine levels in China.

Purpose: Autoimmune thyroiditis (AIT) results from a combination of genetic predispositions and environmental factors. This study aims to examine the methylation patterns of genes that mediate autophagosome formation (MAF) between AIT patients and controls from areas with different water iodine levels.

Methods: A protein-protein interaction (PPI) network was constructed to explore the interactions of autophagy-related genes (ARGs).

Predictors and Prognostic Effects of Perioperative Myocardial Injury After Transcatheter Aortic Valve Replacement According to VARC-3 Criteria.

Purpose: The impact of periprocedural myocardial injury (PPMI) according to VARC-3 criteria in patients undergoing transcatheter aortic valve replacement (TAVR) remains unclear. This study aimed to investigate the incidence, risk factors, and prognosis of PPMI in patients with severe aortic who underwent TAVR in China.

Materials And Methods: Between September 2012 and November 2021, 516 patients with severe aortic stenosis who underwent TAVR at the Fuwai Hospital were consecutively enrolled.

H4K12 Lactylation Activated-Spp1 in Reprogrammed Microglia Improves Functional Recovery After Spinal Cord Injury.

Background: Spinal cord injury (SCI) is a severe condition leading to significant disability and high mortality. The role of the secreted phosphoprotein 1 (SPP1) signaling pathway in SCI, which is quickly activated after injury, is critical for intercellular communication but remains poorly understood.

Aims: This study aimed to explore the function and regulatory mechanisms of the SPP1 signaling pathway in SCI and investigate its potential as a therapeutic target for improving functional recovery after injury.

Lipid nutritional variances in thermal-treated egg yolks and their influence on flavor formation.

The nutrition and flavor of egg yolks can be affected by poultry species. However, chicken, duck, and goose eggs, as the most common poultry egg products, have not been fully explored. This study explored the lipid composition and flavor differences among three egg yolks via multi-omics, unraveling the flavor-formation mechanisms during thermal treatment.

[Efficacy of endoscopic-assisted resection of congenital first and second branchial cleft malformations in children with external fistula incision approach].

To explore the feasibility of endoscopic-assisted resection of congenital first and second branchial cleft malformations in children via the external fistula incision approach. A retrospective analysis was conducted on 20 children with congenital first and second branchial cleft malformations who were admitted to the Department of Otolaryngology Head and Neck Surgery of Hu'nan Children's Hospital from January 2020 to January 2024 and whose families voluntarily consented to endoscopic surgery. Clinical data were collected.

The effect mechanism of different natural spices on the formation of associated hazardous compounds in roasted chicken.

Exploring the interaction mechanism between the key components in spices and the hazardous compounds in thermally processed foods will help in improving the safety level of processed foods, which is of great significance to the food field. This paper investigated the inhibitory regularities and mechanisms of 6 natural spices on 15 associated hazardous compounds in the chicken. Dried ginger and black pepper had the best inhibitory effects, dried ginger had inhibitory effects on 13 hazardous compounds, and the average inhibition rate ranged from 20.

Transcytosis-Triggering Nanoparticles for Overcoming Stromal Barriers and Reversing Immunosuppression in Pancreatic Cancer Combinatorial Therapy.

In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that, while preventing the outward spread of tumor cells, also limits the penetration of drugs and CD8 T cells inward. Additionally, the overactivated TGF-β/SMAD signaling pathway further promotes matrix proliferation and immune suppression. Therefore, crossing the stromal barrier while preserving the integrity of the stroma, releasing drugs intratumorally, remodeling the stroma, and activating the immune system is a promising drug delivery strategy.

Identifying spatiotemporal pattern and trend prediction of land subsidence in Zhengzhou combining MT-InSAR, XGBoost and hydrogeological analysis.

Zhengzhou city (China) experienced relatively significant land deformation following the July 20, 2021, extreme rainstorm (7·20 event). This study jointly utilised Multi-temporal synthetic aperture radar interferometry (MT-InSAR), eXtreme Gradient Boosting (XGBoost), and hydrogeological analysis to quantitatively assess the extent and trends, as well as the causes of land deformation before and after the 7·20 event in Zhengzhou city. The findings detected three major subsidence zones and two uplift zones within the city.

Case report: Detection and treatment of a rare submucosal gland duct adenoma of the esophagus.

This article reports a rare case of esophageal submucosal gland duct adenoma (ESGDA). The patient was found to have this tumor after undergoing endoscopy in an outpatient clinic due to occasional tingling while eating. White light endoscopy revealed the tumor as a dumbbell-shaped bulge, and ultrasound endoscopy revealed it as a hypoechoic mass located in the submucosal layer.

Stepwise Chemical Reduction of [4]Cyclo[4]helicenylene: Stereo Transformation and Site-Selective Metal Complexation.

A highly strained macrocycle comprising four [4]helicene panels, [4]cyclo[4]helicenylene ([4]CH, ), was synthesized through a one-pot macrocyclization and chemically reduced by alkali metals (Na and K), revealing a four-electron reduction process. The resulting di-, tri-, and tetraanions of compound were isolated and crystallographically characterized by X-ray diffraction. Owing to the four axially chiral bi[4]helicenyl fragments, a reversible stereo transformation of between the (,,,)- and (,,,)-configurations was disclosed upon the two-electron uptake, which was rationally understood by theoretical calculations.

Atomically Dispersed Co-P Moieties via Direct Thermal Exfoliation for Alkaline Hydrogen Electrosynthesis.

The development of highly active and stable cathodes in alkaline solutions is crucial for promoting the commercialization of anion exchange membrane (AEM) electrolyzers, yet it remains a significant challenge. Herein, we synthesized atomically dispersed CoP moieties (CoP-SSC) immobilized on ultrathin carbon nanosheets via a phosphidation exfoliation strategy at medium temperature. The thermodynamic formation process of the Co-P moieties was elucidated using X-ray absorption spectroscopy (XAS) and theoretical calculations.