In situ formation of boronic acid-based covalent organic frameworks for specific and ultra-sensitive electrochemical assay of glycosylated amyloid-beta proteins.

Alzheimer's disease (AD) significantly impacts the well-being of older people around the world. However, the accurate detection of glycosylated amyloid-beta (Aβ) proteins, which serve as important biomarkers for AD, remains challenging due to their extremely low levels. To address these issues, we proposed a method for fabricating a flexible and stable sensor platform based on an innovative boronic acid-based covalent organic framework COF-B(OH).

Associations of serum uric acid-to-high density lipoprotein cholesterol ratio with age-related diseases and mortality among older population in the United States.

Background: Older adults experience numerous physiological and socioeconomic changes that increase the risk of chronic diseases. The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a potential biomarker for assessing various health conditions. This study aimed to investigate the relationship between UHR and the prevalence of age-related diseases and mortality in a nationally representative sample of older adults in the United States.

IGFBP5 affects cardiomyocyte survival and functional recovery in mice following myocardial ischemia.

Insulin-like growth factor-binding protein 5 (IGFBP5) has been shown to be useful for the diagnosis and treatment of multiple tumors and cerebrovascular diseases. However, it is unknown whether IGFBP5 is involved in myocardial repair following myocardial infarction (MI). Here we show high expression of IGFBP5 in multiple models of ischemic and hypoxic injury.

Prognostic value of mechanical dyssynchrony in patients with heart failure: a systematic review.

Background: Heart failure (HF) significantly impacts quality of life and healthcare systems worldwide. Assessing left ventricular mechanical dyssynchrony (LVMD) is crucial for understanding cardiac function and optimizing treatments like cardiac resynchronization therapy (CRT). Phase analysis using gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has shown promise in predicting outcomes, yet recent comprehensive reviews are lacking.

Amorphous MoS Anchored within Hollow Carbon as a Cathode Material for Magnesium-Ion Batteries.

Magnesium-ion batteries are considered the next-generation promising large-scale energy storage devices owing to the low-cost and nondendritic features of metallic Mg anode. Nevertheless, such strong electrostatic interaction between bivalent Mg and crystalline cathode materials will lead to low capacity and poor diffusion kinetics, which seriously hinders the further development of magnesium-ion batteries. Herein, amorphization and anion-rich strategies are employed to prepare well-designed cathode materials with MoS anchored on hollow carbon nanospheres (a-MoS/HCS).

Effects of maternal posture and cognitive-behavioral interventions on labor outcomes in primigravidas with abnormal fetal head position: a randomized controlled clinical trial.

Objective: Fetal head malposition can result in neonatal and maternal complications. Fetal head malposition occurs frequently in labor. Appropriate and timely managements are required.

Relationships between organizational support, emotional intelligence and work engagement among Chinese nurses: A correlation study.

Aim: To investigate and analyse the current situation of clinical nurses' sense of organisational support, emotional intelligence and work engagement in different departments and their correlation, in order to provide guidance for enhancing the sense of organisational support, improving nurses' emotional intelligence and mobilising nurses' work engagement and to promote the development of nursing teams.

Methods: Clinical nurses from three hospitals in eastern and western China were selected by convenience sampling method from September to October 2023 and were surveyed using a general information questionnaire, organisational support questionnaire, emotional intelligence scale and work engagement scale. We investigated the correlation between nurses' sense of organisational support, emotional intelligence and work engagement in clinical units.

Resistant starch confers protection of dietary against diabetic cardiomyopathy.

Long-term dysfunction of glucose metabolism causes cardiac dysfunction called diabetic cardiomyopathy (DCM). To investigate the effect and underlying mechanism of RS on the process of DCM, mouse models induced by a high-fat diet (HFD) and streptozotocin (STZ) were fed RS (2 g/kg/day) and vehicle treatment (by oral gavage) for 14 weeks. Various analyses, including qRT-PCR, western blot, immunofluorescence staining, histology staining, cardiac function, and diversity detection of intestinal microbiota were performed.

TAFRO syndrome with abdominal pain as the first symptom accompanied by liver damage with hyperbilirubinemia: A case report.

Thrombocytopenia, anasarca, fever, reticulin fibrosis on bone marrow biopsy/renal dysfunction, and organomegaly (TAFRO) syndrome are infrequent conditions with diverse clinical and pathological characteristics related to multi-organ damage. There are few reports of TAFRO syndrome accompanied by liver damage with hyperbilirubinemia. We describe the case of a 61-year-old male who presented with sudden onset abdominal pain accompanied by liver damage with hyperbilirubinemia.

Decorating Cage-Shaped Cavities with Carboxyl Groups on Two-Dimensional MOF Nanosheet for Trace Uranium(VI) Trapping.

The efficient and complete extraction of uranium from aqueous solutions is crucial for safeguarding human health from potential radiotoxicity and chemotoxicity. Herein, an ultrathin 2D metal-organic framework (MOF) nanosheet with cavity structures was elaborately constructed, based on a calix[4]arene ligand. The large molecular skeleton and cup-shaped feature of the calix[4]arene enabled the as-prepared MOFs with large layer separations, which can be readily delaminated into ultrathin single-layer (∼1.

Combined traditional Chinese medicine therapy for the treatment of infertility with polycystic ovary syndrome: A network meta-analysis of randomized controlled trials.

Background: Polycystic ovary syndrome (PCOS) infertility has attracted great attention from researchers due to its high incidence. Numerous studies have shown that Chinese medicine is effective in treating this disease, but there is a wide variety of Chinese medicine therapies available, and there is a lack of comparative evaluation of the efficacy of various Chinese medicine combination therapies in the clinic, which requires further in-depth exploration. This study aims to evaluate the efficacy of a combined traditional Chinese medicine (TCM) therapy for the treatment of infertility with PCOS using network meta-analysis (NMA).

Psychometrics validation of the Chinese version of social support for exercise scale among adolescents in China.

Physical activity (PA) is widely recognized as crucial for human health, yet the low level of PA in adolescents continues to raise major concerns. This study aims to validate the Chinese version of the Social Support Scale for Exercise (SE) and establish its reliability among Chinese adolescents. A cross-sectional study was conducted on two primary and two secondary schools in central China.

Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020.

Background: Early-life cardiovascular risk factors (CVRFs) are known to be associated with target organ damage during adolescence and premature cardiovascular morbidity and mortality during adulthood. However, contemporary data describing whether the prevalence of CVRFs and treatment and control rates have changed are limited. This study aimed to examine the temporal trends in the prevalence, treatment, and control of CVRFs among US adolescents over the past 2 decades.

Using haematological indices to predict impaired liver function in DTC patients.

Objective: In patients with normal liver function, patients with acute or chronic thyroid disease are more likely to develop liver dysfunction. Although the mechanisms underlying this process are not yet fully understood, it has been shown that hypothyroidism can lead to hepatic injury. We evaluated haematological function trends in patients with differentiated thyroid cancer (DTC) at baseline and approximately 4 weeks after l-thyroxine withdrawal before radioactive iodine ablation.

Genome and GWAS analysis identified genes significantly related to phenotypic state of bark.

As an important horticultural plant, is often used in urban greening and landscape design. However, factors such as the high rate of genetic recombination, frequent outcrossing in the wild, weak linkage disequilibrium, and the susceptibility of gene expression to environmental factors limit further exploration of functional genes related to important horticultural traits, and make the breeding of new varieties require a longer time. Therefore, we choose bark as the target trait which is not easily affected by environmental factors, but also has ornamental properties.

Evaluating the efficacy and safety of oral triple sequential combination therapy for treating patients with pulmonary arterial hypertension: A multicenter retrospective study.

This study aimed to evaluate the effectiveness and safety of an oral sequential triple combination therapy with selexipag after dual combination therapy with endothelin receptor antagonist (ERA) and phosphodiesterase-5 inhibitor (PDE5I)/riociguat in pulmonary arterial hypertension (PAH) patients. A total of 192 PAH patients from 10 centers had received oral sequential selexipag therapy after being on dual-combination therapy with ERA and PDE5i/riociguat for a minimum of 3 months. Clinical data were collected at baseline and after 6 months of treatment.

Impact of vector richness on the risk of vector-borne disease: The role of vector competence.

A central goal of disease ecology is to identify the factors that drive the spread of infectious diseases. Changes in vector richness can have complex effects on disease risk, but little is known about the role of vector competence in the relationship between vector richness and disease risk. In this study, we firstly investigated the combined effects of vector competence, interspecific competition, and feeding interference on disease risk through a two-vector, one-host SIR-SI model, and obtained threshold conditions for the occurrence of dilution and amplification effects.

Impact of different sequential triple oral combination therapies based selexipag on outcomes in pulmonary arterial hypertension.

Background: While the GRIPHON study and others have confirmed the efficacy and safety of selexipag with single, dual, and initial triple combination therapy for patients with pulmonary arterial hypertension (PAH), multicenters studies concerning diverse triple oral combination therapies based on selexipag are limited.

Hypothesis: This study was conducted to evaluate the effects of various sequential triple oral combination therapies on PAH outcomes.

Methods: A retrospective study was carried out involving 192 patients from 10 centers, who were receiving sequential triple oral combination therapy consisting of an endothelin receptor antagonist (ERA), a phosphodiesterase 5 inhibitor (PDE5i)/riociguat and selexipag.

Low-concentration exogenous 3-indoleacetic acid improves fruit-setting rate of Marsdenia tenacissima by inhibiting the expression of embryo abortion-related genes.

Marsdenia tenacissima is a medicinal plant characterized by many flowers, few fruits, and a low fruit-setting rate. Exogenous auxins can improve the fruit-setting rate of plants; however, their impacts on M. tenacissima and regulatory mechanisms remain unclear.

Development and validation of a diagnostic nomogram in pulmonary hypertension due to left heart disease.

Background: Pulmonary hypertension (pH) due to left heart disease (pH-LHD) is the most common form of pH in clinical practice.

Objectives: The purpose of the study is to develop a diagnostic nomogram predictive model combining conventional noninvasive examination and detection indicators.

Methods: Our study retrospectively included 361 patients with left heart disease (LHD) who underwent right heart catheterization between 2013 and 2020.

Ratiometric electrochemical determination of hydroxyl radical based on graphite paper modified with metal-organic frameworks and impregnated with salicylic acid.

Hydroxyl radical (•OH) detection is pivotal in medicine, biochemistry and environmental chemistry. Yet, electrochemical method-specific detection is challenging because of hydroxyl radicals' high reactivity and short half-life. In this study, we aimed to modify the electrode surface with a specific recognition probe for •OH.

Positive Synergy between the Helical Poly(phenylacetylene) Backbones and the Helical -Proline Oligopeptide Pendants for Enhanced Enantioseparation Properties.

A series of optically active helical poly(phenylacetylene)s (, , , , and ) bearing different chain lengths of -proline oligopeptide in the side chains were obtained by polymerizing the corresponding novel phenylacetylene monomers. The monomer adopted a -rich helix structure when the -proline oligopeptide chain length was longer, according to the optical activities and 2D-NMR analysis. The helical structure could be maintained and significantly influenced the polymers' helical conformation by introducing the -proline oligopeptide to the pendants.