Bioinformation study of immune microenvironment characteristics of disulfidptosis-related subtypes in ovarian cancer and prognostic model construction.

Objective: Ovarian cancer significantly impacts women's reproductive health and remains challenging to diagnose and treat. Despite advancements in understanding DNA repair mechanisms and identifying novel therapeutic targets, additional strategies are still needed. Recently, a novel form of cell death called disulfidptosis, which is triggered by glucose deprivation, has been linked to treatment resistance and changes in the tumor microenvironment (TME).

Mesoporous TiO@g-CN Nanostructure-Enhanced Photocatalytic Degradation of Tetracycline Under Full-Spectrum Sunlight.

TiO has broad prospects in reducing the safety risks posed by emerging pollutants in water environments. However, the high recombination rate of photogenerated carriers limits the activity and photon utilization efficiency of TiO. In this study, mesoporous TiO (m-TiO) and ultra-thin g-CN nanosheets were composited using a hydrothermal method, with the m-TiO tightly and uniformly wrapped by g-CN.

Effect of Solution Treatment on the Microstructure and Elevated Temperature Tensile Properties of Forged Rene 41 Superalloy.

The effects of a solution treatment on the microstructure and elevated mechanical properties of the forged Rene 41 superalloy were investigated. The results indicate that the solution treatment temperature has a significant influence on the γ' structure and mechanical properties. The sub-solvus solution treatment resulted in the co-existence of residual primary coarse γ' precipitates and fine secondary γ' precipitates, while the super-solvus solution treatments led to the complete dissolution of the primary γ' precipitates and the precipitation of a nano-sized secondary spherical γ' precipitate.

Exploration of the feasibility of clinical application of phage treatment for multidrug-resistant -induced pulmonary infection.

() commonly induces refractory infection due to its multidrug-resistant nature. To date, there have been no reports on the application of phage treatment for infection. This study was conducted to explore the feasibility of phage application in treating refractory infection by collaborating with a 59-year-old male patient with a pulmonary infection of multidrug-resistant Our experiments included three domains: ) selection of the appropriate phage, ) verification of the efficacy and safety of the selected phage, ) confirmation of phage-bacteria interactions.

Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population.

Background: Keratoconus (KC) is a prevalent corneal condition with a modest genetic basis. Recent studies have reported significant genetic associations in multi-ethnic cohorts. However, the situation in the Chinese population remains unknown.

Enhancing the Performance of Hole-Conductor-Free Printable Mesoscopic Perovskite Solar Cells through Polyaniline-Mediated Iodine Recycling and Defect Passivation.

Printable mesoscopic perovskite solar cells (p-MPSCs) provide an opportunity for low-cost manufacturing of photovoltaics. However, the performance of p-MPSCs is severely compromised by iodine defects. This study presents a strategy by incorporating polyaniline (PANI) to achieve both iodine recycling and iodine defect passivation to significantly improve the performance of p-MPSCs.

Global, regional and national burdens of chronic kidney disease due to T1DM and T2DM among adolescents and young adults aged 10-35 years from 1990-2021: A trend analysis based on the global burden of disease study 2021.

Backgrounds: Chronic kidney disease (CKD) is a major complication of diabetes, which is rising among adolescents and young adults worldwide, but data on the trends of these diseases are sparse. This study examined the burden of CKD due to type 1 diabetes (CKD-T1D) and type 2 diabetes (CKD-T2D) among those aged 10-35 from 1990 to 2021 on global, regional, and national levels.

Methods: Using Global Burden of Disease 2021 data, joinpoint regression analysis and decomposition analysis were employed to identify significant changes in CKD-T1D and CKD-T2D trends, including incidence, prevalence, mortality, and disability-adjusted life years (DALYs).

Association between remnant cholesterol (RC) and endometriosis: a cross-sectional study based on NHANES data.

Background: Prior research indicates a potential link between dyslipidemia and endometriosis (EMs). However, the relationship between remnant cholesterol (RC) and EMs has not been thoroughly investigated. Consequently, looking into and clarifying the connection between RC and EMs was the primary goal of this study.

Diagnostic Value of Circulating microRNAs for Hepatocellular Carcinoma: Results of a Meta-analysis and Validation.

Mounting evidence suggests that circulating microRNAs (miRNAs) hold diagnostic value in various malignancies. To identify circulating miRNAs for the early diagnosis of hepatocellular carcinoma (HCC), we conducted a meta-analysis to evaluate the diagnostic utility of miRNAs in HCC and further validated the results of the meta-analysis. English articles published prior to December 2023 were retrieved from databases including PubMed, Embase, and Web of Science.

Network analysis of intergenerational transmission of psychopathological symptom among adolescents: A cross-sectional study.

The intergenerational transmission of psychopathology has been well documented, but limited studies have examined the link at the symptomatic level accounting for these associations. This study aimed to identify the central symptoms that bridge adolescents and parental psychopathological symptoms and the specific symptom pathways by using a novel network approach. From September to October 2021, a cross-sectional study was conducted in Wuhan, China.

Development of Betalain-immobilized polylactic acid nanofibers as a green and sustainable sensor for toxic ammonia.

Ammonia has been an important industrial colorless agent. Exposure to gaseous ammonia results in organ damage or even death. Herein, an environmentally friendly colorimetric detector for aqueous and gaseous ammonia was prepared utilizing vapochromic polylactic acid nanofibers.

Real-time risk estimation for active road safety: Leveraging Waymo AV sensor data with hierarchical Bayesian extreme value models.

Near-miss traffic risk estimation using Extreme Value Theory (EVT) models within a real-time framework offers a promising alternative to traditional historical crash-based methods. However, current approaches often lack comprehensive analysis that integrates diverse roadway geometries, crash patterns, and two-dimensional (2D) vehicle dynamics, limiting both their accuracy and generalizability. This study addresses these gaps by employing a high-fidelity, 2D time-to-collision (TTC) near-miss indicator derived from autonomous vehicle (AV) sensor data.

Fast and Efficient Screening and Separation Based on AUF-MS Combined With Molecular Docking Technology and Network Pharmacology Method for Potential Xanthine Oxidase Inhibitors From Pinelliae Rhizoma Praeparatum.

Introduction: Studies show that Pinelliae Rhizoma Praeparatum (PRP) has some pharmacological effects in enhancing immunity and against gout.

Objectives: A mathematical model was created for extraction process optimization, analysis and identification, activity screening, and isolation and purification; moreover, the mechanism of action was studied.

Methods: First, the extraction of PRP was investigated using the gray wolf optimization mathematical regression model; the extraction variables were optimized to maximize the yield.

In vivo imaging of glycogen in human muscle.

Probing regional glycogen metabolism in humans non-invasively has been challenging due to a lack of sensitive approaches. Here we studied human muscle glycogen dynamics post-exercise with a spatial resolution of millimeters and temporal resolution of minutes, using relayed nuclear Overhauser effect (glycoNOE) MRI. Data at 5T showed a homogeneous distribution of glycogen in resting muscle, with an average concentration of 99 ± 13 mM.

Structure-Based Design of "Head-to-Tail" Macrocyclic PROTACs.

Macrocyclization is a compelling strategy for conventional drug design for improving biological activity, target specificity, and metabolic stability, but it was rarely applied to the design of PROTACs possibly due to the mechanism and structural complexity. Herein, we report the rational design of the first series of "Head-to-Tail" macrocyclic PROTACs. The resulting molecule exhibited pronounced Brd4 protein degradation with low nM DC values while almost totally dismissing the "hook effect", which is a general character and common concern of a PROTAC, in multiple cancer cell lines.

Association between the ratio of serum uric acid to high-density lipoprotein cholesterol and liver fat content: evidence from a Chinese health examination dataset.

Despite numerous studies investigating the correlation between the serum uric acid and high-density lipoprotein cholesterol ratio (UHR) and fatty liver disease, the evidence for the dose-response relationship between UHR and liver fat content (LFC) remains uncertain. This study employs quantitative computed tomography (CT) to quantify LFC and aims to investigate the correlation and dose-response relationship between UHR levels and LFC in Chinese adults. Based on the health check-up data from 2021 at Henan Provincial People's Hospital, China, the objective of this cross-sectional study was to investigate the association between UHR levels and LFC among individuals of different genders.

Evaluation of Facial Symmetry in Congenital Unilateral Lower Lip Palsy Patients with Depressor Labii Inferioris Muscle Resection.

Background: Congenital hypoplasia of the depressor labii inferioris muscle can lead to Asymmetrical crying facies(ACF). The objective of this research was to examine the alterations in both static and dynamic facial symmetry following the resection of the depressor labii inferioris on the healthy side through an intraoral approach.

Methods: Patients exhibiting palsy of the depressor labii inferioris muscles were included in the study.

Comparison of Population Pharmacokinetic Modeling and Machine Learning Approaches for Predicting Voriconazole Trough Concentrations in Critically Ill Patients.

Despite the widespread use of voriconazole in antifungal treatment, its high pharmacokinetic and pharmacodynamic variability may lead to suboptimal efficacy, especially in intensive care unit (ICU) patients. Machine learning (ML), an artificial intelligence modeling approach, is increasingly being applied to personalized medicine. The effectiveness of ML models for predicting voriconazole blood concentrations in ICU patients, compared to traditional population pharmacokinetics (popPK) models, has been uncertain until now.

Insights into the Assembly of Peptides Catalyzed by Polysaccharides.

Nucleation is a critical step that determines the assembly pathway and the structure and functions of the peptide assemblies. However, the dynamic evolution of interactions between nucleating agents and peptides, as well as between peptides themselves during the nucleation process, remains elusive. Herein, we show that the heterogeneous nucleating agent carboxymethylcellulose (CMC) can promote the nucleation of Aβ (KF) peptide.

An Integrated Analysis of the Role of Gut Microbiome-Associated Metabolites in the Detection of MASH-Related Cirrhosis.

Background And Aim: The prevalence and adverse outcomes of metabolic dysfunction associated with steatotic liver disease (MAFLD) are increasing. The changes in the gut microbiota and metabolites associated with metabolic dysfunction-associated steatohepatitis (MASH) are regarded as an essential part of the progression of MAFLD. This study aimed to identify the gut microbiota and metabolites involved in the development of MAFLD in patients.

Preoperative clinical and contrasted-enhanced CT features to predict perineural invasion in gallbladder carcinoma: focus on clinical T3-4 stage.

Purpose: To investigate the utility of combining clinical and contrasted-enhanced tomography (CECT) parameters for the preoperative evaluation of perineural invasion (PNI) in gallbladder carcinoma (GBC).

Methods: A total of 134 patients with GBC (male/female, 52/82; age, 64.4 ± 9.