Recurrent acute myocardial infarction associated with calcified pseudoaneurysm: A case analysis.

Left ventricular pseudoaneurysm (LVP), a rare but life-threatening complication following acute myocardial infarction (AMI), has an incidence of approximately 0.5% and a high mortality rate due to its significant risk of rupture. Early detection and timely surgical intervention are crucial.

Genome mining and metabolite profiling illuminate the taxonomy status and the cytotoxic activity of a mangrove-derived Microbacterium alkaliflavum sp. nov.

The genus Microbacterium in the phylum Actinomycetota contains over 100 species to date that little is known about their bioactive metabolites production. In this study, a mangrove sediment-derived strain B2969 was identified as a novel type strain within the genus Microbacterium due to the low 16S rRNA gene sequence similarity (< 99%), and low overall genome relatedness indices (ANI, 75.4%-79.

Notopterol mitigates osteoarthritis progression and relieves pain in mice by inhibiting PI3K/Akt/GPX4-mediated ferroptosis.

Ferroptosis-induced lipid peroxidation in chondrocytes exacerbates intra-articular inflammation, oxidative stress, and articular cartilage degradation, accelerating osteoarthritis (OA) progression. Effective anti-inflammatory and antioxidant interventions can alleviate both joint pain and cartilage damage. This study aims to elucidate the therapeutic effects of Notopterol (NP), a bioactive compound extracted from the rhizome of Notopterygium incisum, a traditional Chinese medicine known for its potent anti-inflammatory and antioxidant properties, in treating OA.

Physiochemical properties of V-type cold water swelling tapioca starch prepared by ethanolic extrusion.

This study developed V-type cold-water swelling tapioca starch (VCSTS) through ethanolic extrusion from tapioca starch and examined the effects of various extrusion conditions on its physiochemical properties. The findings revealed that ethanolic extrusion transforms tapioca starch from A-type to V-type crystalline structure, giving VCSTS cold-water solubility/swelling capacity. XRD, FTIR, and SEM analyses confirmed that VCSTS produced under optimal conditions (extrusion temperature of 90 °C, 40 % ethanol solution, a starch-to-ethanol solution ratio of 1: 0.

Debranching by enzymatic extrusion of oat flour for enhanced amylose-lipid complex formation: Effects on in vitro digestibility and functional properties.

The amylose-lipid complex, also known as resistant starch type 5, is classified as dietary fibre with well-recognized health benefits. This study investigated its formation in pre-gelatinized whole oat flour using enzymatic extrusion-debranching and evaluated its effects on in vitro digestibility and functional properties. Whole oat grains were cooked in a steam oven, dried, ground, blended with pullulanase (60 U/g), and extruded enzymatically.

Association between psoriasis and Life's Essential 8 among adults in the United States.

This study aimed to investigate the association between psoriasis and Life's Essential 8 (LE8), which has demonstrated an inverse relationship with various chronic diseases, though its link to psoriasis remains unexplored. In this cross-sectional study, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) conducted during 2005 to 2006 and 2009 to 2014 that included participants who were 20 years or older. The LE8 score was calculated based on the American Heart Association's recommendations and categorized into three levels: low (0-49), moderate (50-79), and high (80-100).

Association of MiRNA Polymorphisms Involved in the PI3K/ATK/GSK3β Pathway with T2DM in a Chinese Population.

Background: Single nucleotide polymorphisms (SNPs) in miRNA genes can influence the expression of miRNAs that modulate the PI3K/AKT/GSK3β pathway and play crucial roles in type 2 diabetes mellitus (T2DM) susceptibility. The purpose of this study was to investigate the association of SNPs in miRNA genes targeting the PI3K/AKT/GSK3β pathway with T2DM.

Methods: This case-control study included 1,416 subjects with T2DM and 1,694 non-diabetics.

Pharmacogenomics-based subtype decoded implications for risk stratification and immunotherapy in pancreatic adenocarcinoma.

Background: With fatal malignant peculiarities and poor survival rate, outcomes of pancreatic adenocarcinoma (PAAD) were frustrated by non-response and even resistance to therapy due to heterogeneity across clinical patients. Nevertheless, pharmacogenomics has been developed for individualized-treatment and still maintains obscure in PAAD.

Methods: A total of 964 samples from 10 independent multi-center cohorts were enrolled in our study.

Critical role of Oas1g and STAT1 pathways in neuroinflammation: insights for Alzheimer's disease therapeutics.

Background: Alzheimer's disease (AD) has a significant impact on an individual's health and places a heavy burden on society. Studies have emphasized the importance of microglia in the progression and development of AD. Interferon responses and Interferon-stimulated genes (ISGs) significantly function in neuroinflammatory and neurodegenerative diseases involving AD.

Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy.

Background: Neuroblastoma, a prevalent extracranial solid tumor in pediatric patients, demonstrates significant clinical heterogeneity, ranging from spontaneous regression to aggressive metastatic disease. Despite advances in treatment, high-risk neuroblastoma remains associated with poor survival. SLC1A5, a key glutamine transporter, plays a dual role in promoting tumor growth and immune modulation.

Plant Diversity Reduces the Risk of Antibiotic Resistance Genes in Agroecosystems.

Despite advances in dispersal mechanisms and risk assessment of antibiotic resistance genes (ARGs), how plants influence ARG contamination in agricultural soils remains underexplored. Here, the impacts of plant species and diversity on ARGs and mobile genetic elements (MGEs) in three agricultural soils are comprehensively investigated in a pot experiment. The results indicate that increased plant diversity reduces ARGs and MGEs abundance by 19.

Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy.

Traumatic hemorrhage and infection are major causes of mortality in wounds caused by battlefield injuries, hospital procedures, and traffic accidents. Developing a multifunctional nano-drug capable of simultaneously controlling bleeding, preventing infection, and promoting wound healing is critical. This study aimed to design and evaluate a nanoparticle-based solution to address these challenges effectively.

From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery.

Biomimetic nanodrug delivery systems based on cell membranes have emerged as a promising approach for targeted cancer therapy due to their biocompatibility and low immunogenicity. Among them, platelet-mediated systems are particularly noteworthy for their innate tumor-homing and cancer cell interaction capabilities. These systems utilize nanoparticles shielded and directed by platelet membrane coatings for efficient drug delivery.

Unveiling the electrochemical nitrogen reduction reaction mechanism in heteroatom-decorated-MoCS-MXene: the synergistic effect of single-atom Fe and heteroatom.

Conversion of nitrogen (N) to ammonia (NH) is a significant process that occurs in environment and in the field of chemistry, but the traditional NH synthesis method requires high energy and pollutes the environment. In this work, the charge, orbital and spin order of the single-atom Fe loaded on heteroatom (X) doped-MoCS (X = B, N, O, F, P and Se) and its synergistic effect on electrochemical nitrogen reduction reaction (eNRR) were investigated using well-defined density functional theory (DFT) calculations. Results revealed that the X-element modified the charge loss capability of Fe atoms and thereby introduced a net spin through heteroatom doping, resulting in the magnetic moment modulation of Fe.

The dCas9/crRNA linked immunological assay (dCLISA) for sensitive, accurate, and facile drug resistance gene analysis.

The rapid and reliable diagnosis of methicillin-resistant Staphylococcus aureus (MRSA) is essential for preventing the spread of MRSA infections and guiding therapeutic strategies. However, there is still a huge challenge in further simplifying MRSA detection procedures and improving detection selectivity to reduce false-positive results. In this study, we developed a derivative CRISPR-associated protein 9/CRISPR-derived RNA Linked Immunological Assay (dCLISA) for the sensitive and specific detection of MRSA.

Synergistic machine learning models utilizing ferroptosis-related genes for improved neuroblastoma outcome prediction.

Background: Neuroblastoma (NB) is a highly heterogeneous and common pediatric malignancy with a poor prognosis. Ferroptosis, an iron-dependent cell death pathway, may play a crucial role in NB tumor progression and immune response. This study aimed to investigate ferroptosis in NB to identify potential therapeutic targets and develop predictive models for prognosis and recurrence.

Examination of spatial and temporal evolution characteristics of carbon emission and influencing factors in territorial spatial functional areas: a case study of the mountainous city Chongqing.

The rapid development of China's economy and the acceleration of the urbanization process have led to a significant increase in carbon emissions, and more effective policies are urgently needed. As the first city in China to be approved for the overall master plan of territorial space, Chongqing is facing new opportunities in urban construction. This research constructed a classification system of the territorial space functional areas in Chongqing (CQ-TSFA) and matched the corresponding carbon emission and carbon sequestration projects.

Innovative applications of bio-inspired technology in bio-based food packaging.

Traditionally, food packaging was used to extend the shelf life of food or to monitor its condition. Inspired by many biological structures found in nature, bio-inspired functional materials for bio-based food packaging have been shown to have significantly improved capabilities over traditional bio-based food packaging materials in various aspects and to attract consumers through novel freshness preservation features. This review synthesizes recent advances in bio-inspired bio-based food packaging materials that mimic the structure of natural organisms with specific functionalities, with examples of specific biomimetics in different enhancement areas.

Purification, characterization, and mechanistic studies of Gassericin GA-3.1: A novel class IIc bacteriocin produced by Lactobacillus gasseri LG145.

Bacteriocins, naturally derived antimicrobial peptides, are considered promising alternatives to traditional preservatives and antibiotics, particularly in food and medical applications. Despite extensive research on various bacteriocins, cyclic varieties remain understudied. This study introduces Gassericin GA-3.

Machine Learning-Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug-Drug Self-Assembly.

Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-assembling nanomedicines, employing physiochemical parameters to predict formation via machine learning.

Using reduced sericin as a green resist for precise pattern fabrication via water-based lithography.

The use of toxic resists and complex procedures has impeded the resolution and quality of micro/nanofabrication on virtually arbitrary substrates via photolithography. To fabricate a precise and high-resolution pattern, a sericin nanofilm-based coating was developed by reducing disulfide bonds and subsequently assembling sericin protein. Upon exposure to ultraviolet (UV) light, intermolecular amide bonds in sericin are cleaved through the action of a reducing agent, allowing the reduced sericin (rSer) coating to exhibit the functional ability to generate diverse geometric micro/nanopatterns through photomask-governed photolithography.

Preparation of agar polysaccharides and biological activities and relationships of agar-derived oligosaccharides and monosaccharides: A review.

Agar is one of the three major colloidal linear polysaccharides obtained from marine seaweeds, specifically red macroalgae (Rhodophyta). It has garnered significant attention owing to its diverse industrial applications, potential for bioethanol production, and the physiological activities of its derived saccharides. This review delves into the preparation and degradation processes of agar, focusing on both physical and chemical pretreatments, as well as subsequent hydrolysis through acid and enzymatic methods.

ppb-Level SO Photoacoustic Sensor for SF Decomposition Analysis Utilizing a High-Power UV Laser with a Power Normalization Method.

A highly sensitive sulfur dioxide (SO) photoacoustic gas sensor was developed for the sulfur hexafluoride (SF) decomposition detection in electric power systems by using a novel 266 nm low-cost high-power solid-state pulse laser and a high -factor differential photoacoustic cell. The ultraviolet (UV) pulse laser is based on a passive -switching technology with a high output power of 28 mW. The photoacoustic signal was normalized to the laser power to solve the fluctuation of the photoacoustic signal due to the power instability of the UV laser.

An analysis of extraskeletal osteosarcoma based on the literature.

Extraskeletal osteosarcoma (ESOS) is a very rare malignant tumor. This study aimed to provide more evidence about the natural history and clinical features of ESOS, and clarify the impact of chemotherapy (CT) and radiotherapy (RT) on patient survival and postoperative recurrence for the sake of gaining a better understanding about the disease. Patient/tumor characteristics, recurrence, treatment, and follow-up durations were collected by searching studies in PubMed, Web of Science, Ovid, Elsevier, SpringerLink, Chinese National Knowledge Infrastructure (CNKI), and WAN FANG Data before June 30, 2023.