Publications by authors named "Zhou Wei-Xun"
The median age of patients at diagnosis of mitochondrial neurogastrointestinal encephalomyopathy was 25 years. The most common neurological symptoms were leukoencephalopathy (83.1%), polyneuropathy (68.
View Article and Find Full Text PDFDNA mismatch repair gene MutL homolog-1 (MLH1) has divergent effects in many cancers; however, its impact on the metastasis of pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, MLH1 stably overexpressed (OE) and knockdowned (KD) sublines were established. Wound healing and transwell assays were used to evaluate cell migration/invasion.
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- Autoimmune enteropathy (AIE) is a rare and challenging disease to diagnose and manage in adults, with a study analyzing 16 cases over 12 years to better understand its characteristics and prognosis.
- The study found common symptoms like secretory diarrhea, significant endoscopic findings (like edema and villous blunting), and specific histopathological changes such as reduced goblet and Paneth cells in biopsies.
- While most patients initially responded to glucocorticoid therapy, the prognosis varied, with 62.5% relapse-free survival after 6 months, and some patients facing serious complications, including death and lymphoma diagnosis.
Background: Eosinophilic gastroenteritis (EGE) is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal tract. Glucocorticoids remain the most common treatment method. However, disease relapse and glucocorticoid dependence remain notable problems.
View Article and Find Full Text PDFExpert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma (2022 version).
J Clin Transl Hepatol
December 2023
Article Synopsis
- Intrahepatic cholangiocarcinoma (iCCA) can arise from various parts of the intrahepatic biliary tree and is classified into subtypes based on their origins, such as large duct, small duct, and cholangiolocarcinoma.
- Diagnosing these subtypes is challenging due to differences in cell structure, growth patterns, and other pathological features.
- An expert consensus has proposed nine recommendations to standardize the diagnosis of these iCCA subtypes, referring mainly to the latest World Health Organization classification.
Article Synopsis
- - Emerging research highlights the role of Epstein-Barr virus (EBV) in inflammatory bowel disease (IBD), indicating that immunosuppressive therapies may reactivate latent EBV, worsening patients' conditions.
- - A study analyzed colon specimens from 43 IBD patients to examine the clinical significance of latent EBV infection, finding significant differences in systolic pressure, disease variety, illness severity, and use of corticosteroids between EBV-positive and negative patients.
- - The findings suggest that IBD patients with latent EBV infection may experience more severe disease, warranting further investigation into EBV's role in IBD and careful monitoring of affected patients.
Objectives: To define endoscopic and histological remission in ulcerative colitis (UC) accurately, several scoring systems have been established. A novel virtual electronic chromoendoscopy score, the Paddington International Virtual ChromoendoScopy ScOre (PICaSSO), was developed, validated, and reproduced to assess inflammation grade and predict patient prognosis. We externally verified and validated the clinical value of PICaSSO in UC patients.
View Article and Find Full Text PDFTo first explore the prognostic value of MMP11 and MMP15 in hepatocellular carcinoma. MMP11/MMP15 expression was immunohistochemically detected and correlated with clinicopathologic variables and survival and confirmed in publicly available databases. An MMP-based risk score (MMPRS) was established.
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- FGFR3 has varying effects in different tipos of cancers, and its specific role in pancreatic ductal adenocarcinoma (PDAC) needs more clarity.
- Researchers used RNA interference to reduce FGFR3 levels in PDAC cell lines, confirming that its knockdown leads to decreased cell proliferation and changes in key cell cycle proteins.
- High levels of nuclear FGFR3 in tumor tissues were linked to advanced cancer stages and poor survival rates, and it was identified as an independent poor prognostic factor for patients post-surgery.
Objectives: Cronkhite-Canada syndrome (CCS) is a rare hamartomatous polyposis syndrome with a proposed association with chronic autoimmune inflammation. To date, genetic background of patients with CCS remains less investigated. In this study we aimed to explore the genomic landscape of CCS.
View Article and Find Full Text PDFObjective: Thus far, expression, clinicopathologic, and prognostic implication of small mothers against decapentaplegic 7 (Smad7), matrix metalloproteinase 2 (MMP2), and matrix metalloproteinase 9 (MMP9) in pancreatic ductal adenocarcinoma (PDAC) were rarely investigated or controversial.
Methods: Expression of Smad7, MMP2, and MMP9 was detected using immunohistochemistry in tissue microarrays based on 322 patients with curatively resected PDAC. Their expression pattern, clinicopathologic, and prognostic relevance were further evaluated.
Article Synopsis
- The study aimed to create a standardized white light gastroscopy (WLG) procedure for screening gastric issues, including early gastric cancer, in China, and evaluate its clinical effectiveness.
- A total of 3,207 patients underwent both conventional and standardized WLG procedures across multiple hospitals, revealing that the standardized approach took longer but resulted in a higher detection rate of gastric lesions (52.5% vs 38.4%).
- Participants and endoscopists reported greater satisfaction with the standardized procedure, indicating it is a more effective and feasible option for clinical practice despite the increased time required.
Background: Autoimmune enteropathy (AIE) and primary biliary cholangitis (PBC) are both immune-mediated diseases. AIE or PBC complicated with ulcerative colitis (UC) are rare. There are no cases of AIE and PBC diagnosed after proctocolectomy for UC reported before, and the pathogenesis of these comorbidities has not been revealed.
View Article and Find Full Text PDFBackground: Proliferative abnormalities are believed to represent an early phase of colorectal carcinogenesis. Narrow band imaging (NBI) colonoscopy allows visual assessment of the mucosal vascular pattern (MVP) without dyeing. The aim of this study was to investigate the predictive value of MVP for mucosal proliferation in ulcerative colitis (UC).
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- - The study investigates the role of matrix metalloproteinase 14 (MMP14) in hepatocellular carcinoma (HCC) by analyzing its expression in 260 patients who had surgery for liver cancer.
- - It finds that MMP14 levels are significantly higher in HCC tissue compared to adjacent liver tissue and are associated with larger tumor size and worse survival outcomes.
- - The research suggests that high MMP14 expression is linked to poor prognosis in resectable HCC, confirming its potential as a negative biomarker through both laboratory analysis and online databases.
Article Synopsis
- Primary hypertrophic osteoarthropathy (PHO) is a rare genetic disease linked to mutations in the HPGD and SLCO2A1 genes, with gastrointestinal (GI) issues occurring even less frequently and resembling other autoimmune bowel conditions.
- A study analyzed clinical and genetic data from Chinese PHO patients, comparing those with GI complications to those without, revealing significant differences in symptoms and anemia rates.
- Two male patients with PHO and GI involvement exhibited severe symptoms unresponsive to treatment, with findings of chronic inflammation similar to conditions like cryptogenic multifocal ulcerous stenosing enteritis, and 17.2% of PHO patients reviewed had GI issues.
Article Synopsis
- - The study investigates colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) in China and Canada, comparing clinical and pathological characteristics from 78 patients over 13 years.
- - Results show that the Beijing group had a higher percentage of ulcerative colitis (UC), younger average age at CRC diagnosis, and fewer mucinous adenocarcinomas compared to the Calgary group.
- - Despite these differences, both groups exhibited similar features of IBD-CRC such as prolonged colitis duration, active inflammation, and advanced cancer stages, highlighting some shared risks and characteristics between populations.
Objectives: Thus far, biological roles of plasminogen activator inhibitor 1 (PAI1) in hepatocellular carcinoma (HCC) remain controversial. Moreover, its expression, clinicopathologic and prognostic significance in HCC have not been comprehensively investigated, therefore needing further evidence.
Methods: PAI1 expression was measured, using tissue microarray-based immunohistochemical staining, in matched HCC and adjacent liver samples from 178 patients with HCC after curative resection.
Narrow-Band Imaging Colonoscopy to Assess Mucosal Angiogenesis in Ulcerative Colitis.
Gastroenterol Res Pract
February 2019
Background And Aim: It has been documented that angiogenesis is a largely unstudied component of the pathogenesis of ulcerative colitis (UC). Under narrow-band imaging (NBI) colonoscopy, the mucosal vascular pattern (MVP) can be visualized without the use of dyes. The aim of this study was to assess the grade of mucosal angiogenesis based on the MVP in UC.
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- PAI2 is linked to invasion and prognosis in hepatocellular carcinoma (HCC), but its biological role and mechanisms were not well understood prior to this study.
- Researchers created cell lines with stable overexpression and silencing of PAI2, finding significant differences in migration and invasion capabilities, as well as changes in uPA activity and RB expression.
- The study concludes that PAI2 inhibits HCC cell invasion through mechanisms involving uPA and the RB/E2F1 pathway, with E2F1 being more highly expressed in tumor tissues compared to non-tumor tissues.
Article Synopsis
- The study investigates the role of Plasminogen activator inhibitor 1 (PAI-1) in pancreatic ductal adenocarcinoma (PDAC) to determine its prognostic significance, as previous research suggested its impact on cancer phenotypes.
- PAI-1 levels were measured in tissue samples from 93 PDAC patients, revealing higher expression in tumors compared to non-tumor tissues, and a correlation between high PAI-1 levels and worse tumor-specific survival rates.
- The findings indicate that increased PAI-1 expression is associated with poorer prognosis in PDAC, suggesting it could be used as an independent predictor for long-term outcomes in patients who have undergone surgery for the disease.
Mitogen-activated protein kinase kinase 4 (MKK4) and mitogen-activated protein kinase kinase 7 (MKK7) were shown to regulate biological behavior in many malignancies. In pancreatic ductal adenocarcinoma (PDAC), it remains controversial whether MKK4 and MKK7 have pro-oncogenic or tumor-suppressive activities. Furthermore, their clinicopathological and prognostic implications are unknown.
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- Survivin is a protein linked to cell division and death, found to have significant nuclear expression in pancreatic cancer (PDAC) tumors compared to non-tumor tissues.
- The study analyzed samples from 306 PDAC patients, revealing high Survivin levels correlate with shortened disease-specific survival (DSS) across various patient subgroups.
- While high nuclear Survivin expression indicates a poor prognosis, more research is needed to solidify its role as a reliable prognostic marker in PDAC.
[Clinical Features and Outcomes of Paraduodenal Pancreatitis].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
June 2018
Objective To summarize the clinical features and outcomes of paraduodenal pancreatitis (PP). Methods Five clinically or pathologically diagnosed PP patients in Peking Union Medical College Hospital and 31 other PP cases reported in Chinese literature since 1988 were retrospectively analysed. Results Most PP patients were young or middle-aged males with a history of alcohol abuse.
View Article and Find Full Text PDFBackground: Patients with locally advanced rectal cancer could be managed by a watch-and-wait approach if they achieve clinical complete response after preoperative chemoradiotherapy. Mucosal integrity, endorectal ultrasound, and rectal MRI are used to evaluate clinical complete response; however, the accuracy remains questionable. Clinical practice based on those assessment methods needs more data and discussion.
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