Ambient-condition acetylene hydrogenation to ethylene over WS-confined atomic Pd sites.

Ambient-condition acetylene hydrogenation to ethylene (AC-AHE) is a promising process for ethylene production with minimal additional energy input, yet remains a great challenge due to the difficulty in the coactivation of acetylene and H at room temperature. Herein, we report a highly efficient AC-AHE process over robust sulfur-confined atomic Pd species on tungsten sulfide surface. The catalyst exhibits over 99% acetylene conversion with a high ethylene selectivity of 70% at 25 C, and a record space-time yield of ethylene of 1123 mol mol h under ambient conditions, which is nearly four times that of the typical PdAg/AlO catalyst, and exhibiting superior stability of over 500 h.

Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing.

The healing of diabetic skin wounds is a complex process significantly affected by the hyperglycemic environment. In this context, glucose oxidase (GOx), by catalyzing glucose to produce gluconic acid and hydrogen peroxide, not only modulates the hyperglycemic microenvironment but also possesses antibacterial and oxygen-supplying functions, thereby demonstrating immense potential in the treatment of diabetic wounds. Despite the growing interest in GOx-based therapeutic strategies in recent years, a systematic summary and review of these efforts have been lacking.

SGUQ: Staged Graph Convolution Neural Network for Alzheimer's Disease Diagnosis using Multi-Omics Data.

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the leading cause of dementia, significantly impacting cost, mortality, and burden worldwide. The advent of high-throughput omics technologies, such as genomics, transcriptomics, proteomics, and epigenomics, has revolutionized the molecular understanding of AD. Conventional AI approaches typically require the completion of all omics data at the outset to achieve optimal AD diagnosis, which are inefficient and may be unnecessary.

A protocol for acquiring high-quality single-cell multi-omics data from human peripheral blood.

Single-cell analysis of human peripheral blood cells provides insights into innate and adaptive immune systems. However, robust protocols are essential to ensuring single-cell sequencing data quality and cell viability. Here, we present a protocol for acquiring high-quality single-cell multi-omics data from human peripheral blood mononuclear cells (PBMCs).

Spatial organization of PI3K-PI(3,4,5)P-AKT signaling by focal adhesions.

The class I phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is a key regulator of cell survival, growth, and proliferation and is among the most frequently mutated pathways in cancer. However, where and how PI3K-AKT signaling is spatially activated and organized in mammalian cells remains poorly understood. Here, we identify focal adhesions (FAs) as subcellular signaling hubs organizing the activation of PI3K-PI(3,4,5)P-AKT signaling in human cancer cells containing p110α mutations under basal conditions.

CNN-Informer: A hybrid deep learning model for seizure detection on long-term EEG.

Timely detecting epileptic seizures can significantly reduce accidental injuries of epilepsy patients and offer a novel intervention approach to improve their quality of life. Investigation on seizure detection based on deep learning models has achieved great success. However, there still remain challenging issues, such as the high computational complexity of the models and overfitting caused by the scarce availability of ictal electroencephalogram (EEG) signals for training.

Functional Hexafluoroisopropyl Group Used in the Construction of Biologically Important Pyrimidine Derivatives.

A series of versatile 4-((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)pyridine intermediates have been developed to efficiently produce biaryls, amines, ethers, and thioethers. These hydrolysis-stable ether intermediates exhibit reactivity toward electron-donating groups and nucleophiles in cross-coupling and nucleophilic substitution reactions while surpassing the stability of corresponding aryl halides. In comparison to conventional coupling methods, this protocol offers an alternative pathway for accessing natural product and drug-like compounds without the need for metal catalysts.

The modulation of proteomics and antioxidant stress is involved in the effect of nitazoxanide against Japanese encephalitis virus in vitro.

Japanese encephalitis virus (JEV) is a significant circulating arbovirus flavivirus and the primary cause of viral encephalitis in Asia. Previous studies have demonstrated that nitazoxanide (NTZ), an antiparasitic gastroenteritis medication classified as a thiazolide, exhibits efficacy against JEV both in vitro and in vivo. To explore the potential antiviral mechanisms, we employed Tandem Mass Tag (TMT)-based quantitative proteomics to identify differentially expressed proteins (DEPs) among three groups: Blank cell group, JEV-infected cell group, and JEV-infected cells treated with NTZ.

Respiratory monitoring via a nanoporous film-coated tilted fiber Bragg grating humidity sensor.

A humidity sensor for respiratory monitoring based on a tilted fiber Bragg grating (TFBG) functionalized with a nanoporous coating consisting of titanium carbide (TiC) and fullerene (C) is proposed. By incorporating the C into TiC, a nanocomposite film with abundant three-dimensional porousness is coated on the TFBG surface. The nanocomposite film with strong hygroscopicity and desorption properties is highly sensitive to environmental humidity variations, where the induced refractive index changes of the coating result in the spectral responses of TFBG multi-resonances.

Evaluation of anti-diabetic effects of glimepiride/metformin cocrystal.

Emerging data suggest that cocrystal of two compounds may have a different pharmacological effect from two compounds alone or their physical combination. Glimepiride (Gli) and metformin (Met) are two types of anti-diabetic drugs. Previously, we generated the glimepiride/metformin cocrystal (GM).

Amorphous CoFePO hollow nanocubes decorated with g-CN quantum dots to achieve efficient electrocatalytic performance in the oxygen evolution reaction.

Simultaneously enriching active sites and enhancing intrinsic activity in a simple way is of great importance for the design of highly active electrocatalysts for the oxygen evolution reaction (OER), but it still faces challenges. Herein, g-CN quantum dot decorated amorphous hollow CoFe bimetallic phosphate nanocubes (a-CoFePO@CNQD) are prepared as an efficient OER electrocatalyst by a simple etching-phosphating process. Research shows that their unique hollow architecture and amorphous structure can help provide generous exposed active sites for OER, and the incorporation of g-CN quantum dots can effectively adjust the electronic structure to improve the intrinsic activity.

Dual-payload antibody-drug conjugates: Taking a dual shot.

Antibody-drug conjugates (ADCs) enable the precise delivery of cytotoxic agents by conjugating small-molecule drugs with monoclonal antibodies (mAbs). Over recent decades, ADCs have demonstrated substantial clinical efficacy. However, conventional ADCs often encounter various clinical challenges, including suboptimal efficacy, significant adverse effects, and the development of drug resistance, limiting their broader clinical application.

Targeted Analysis of Mitochondrial Protein Conformations and Interactions by Endogenous ROS-Triggered Cross-Linker Release.

The study of in situ conformations and interactions of mitochondrial proteins plays a crucial role in understanding their biological functions. Current chemical cross-linking mass spectrometry (CX-MS) has difficulty in achieving in-depth analysis of mitochondrial proteins for cells without genetic modification. Herein, this work develops the reactive oxygen species (ROS)-responsive cross-linker delivery nanoparticles (R-CDNP) targeting mitochondria.

A New Intraocular Lens Power Formula Integrating an Artificial Intelligence-Powered Estimation for Effective Lens Position Based on Chinese Eyes.

Purpose: To develop and evaluate a new intraocular lens (IOL) formula based on Chinese eyes.

Methods: A training dataset of 709 eyes undergoing uneventful cataract surgery was used to train the algorithm for effective lens position estimation. The algorithm was then integrated with Gaussian optics to develop the new IOL formula (Jin-AI).

Surface Ligand Evolution: Sulfur-Directed Covalent Bonding of PPh on PdS with Improved Semi-hydrogenation of Terminal Alkynes.

Surface modification of metallic nanocatalysts with organic ligands has emerged as an effective strategy to enhance catalytic selectivity, although often at the expense of catalytic activity. In this study, we demonstrate a compelling approach by surface modifying PdS nanocrystals with PPh ligands, resulting in a catalyst with excellent catalytic activity and durable selectivity for the semi-hydrogenation of terminal alkynes. Experimental and theoretical investigations reveal that the presence of S sites on the Pd surface directs PPh ligands to preferentially form covalent bonds with S, creating distinctive surface S=PPh motifs.

Comprehensive assessment of the association between tumor-infiltrating immune cells and the prognosis of renal cell carcinoma.

Background: According to current statistics, renal cancer accounts for 3% of all cancers worldwide. Renal cell carcinoma (RCC) is the most common solid lesion in the kidney and accounts for approximately 90% of all renal malignancies. Increasing evidence has shown an association between immune infiltration in RCC and clinical outcomes.

Convenient Self-Heating Instant Food Causes Significant Increasing Human Exposure to Organophosphate Esters.

The self-heating lunch box (SHLB) is a kind of popular instant food in China, yet little is known about the associated chemical release risk during its heating process. In this study, we investigated organophosphate esters (OPEs) in original unheated food (UF), SHLB-heated processed food (HF) and potential OPE release from SHLB packaging materials. Significantly higher concentrations of OPEs were observed in HF (267 ± 246 ng/g dry weight (dw)) than in UF (163 ± 211 ng/g dw) ( < 0.

GRK2 Protein Mediates the ANRIL, a lncRNA, to Affect the Proliferation and Apoptosis of Kasumi-1 Cells.

Background: A long non-coding RNAs (LncRNAs) called antisense noncoding RNA in the INK4 locus (), has emerged as substantial regulators of cell survival in acute myeloid leukemia (AML). However, its speciffc and potential mechanism is uncertain in AML. In this research, we investigated the role of in cell proliferation, apoptosis, and the underlying mechanism in AML cells.