Thermoelectric Conversion Eutectogels for Highly Sensitive Self-Powered Sensors and Machine Learning-Assisted Temperature Identification.

Endowing flexible sensors with self-powering capabilities is of significant importance. However, the thermoelectric conversion gels reported so far suffer from the limitations of insufficient flexibility, signal distortion under repetitive deformation, and insufficient comprehensive performance, which seriously hinder their wide application. In this work, we designed and prepared eutectogels by an ionic liquid and a polymerizable deep eutectic solvent (PDES), which exhibit good mechanical properties, adhesion, and excellent thermoelectric conversion and thermoelectric response performance.

Ultrasensitive Bi-Mode Lateral-Flow Assay via UCNPs-Based Host-Guest Assembly of Fluorescent-Colorimetric Nanoparticles.

Fluorescent-colorimetric nanoparticles (FCNPs) attract considerable interest as an emerging dual-signal reporter for on-site qualitative/quantitative point-of-care testing. However, the suboptimal signaling components and self-assembled structure lacking physical isolation in traditional FCNPs result in low fluorescence brightness, poor stability, and strong internal filtration effect (IFE), which severely limits their wide application in lateral flow assay (LFA). Here, ordered self-assembly for hydrophobic upconversion nanoparticles (UCNPs) is developed using 3D porous space magnetic dendritic mesoporous silica (MS), stepwise surface silanization, and polydopamine (PDA) flexible scaffold modification to fabricate MS@UCNPs@PDA (MSUD).

Knowledge-Driven Framework for Anatomical Landmark Annotation in Laparoscopic Surgery.

Accurate and reliable annotation of anatomical landmarks in laparoscopic surgery remains a challenge due to varying degrees of landmark visibility and changing shapes of human tissues during a surgical procedure in videos. In this paper, we propose a knowledge-driven framework that integrates prior surgical expertise with visual data to address this problem. Inspired by visual reasoning knowledge of tool-anatomy interactions, our framework models a spatio-temporal graph to represent the static topology of tool and tissue and dynamic transitions of landmarks' temporal behavior.

Vitexin enhances mitophagy and improves renal ischemia-reperfusion injury by regulating the p38/MAPK pathway.

Vitexin (VI) is a naturally occurring flavonoid derived from the leaves and seeds of Vitex, recognized for its strong antioxidant properties. This study aims to explore its effects on renal ischemia-reperfusion injury (IRI) and investigate the underlying mechanisms. We utilized hypoxia-reoxygenation (H/R) models with HK-2 cell lines and renal ischemia-reperfusion (I/R) models in mice, applying vitexin preconditioning to assess its influence on renal IRI.

Optical enantioseparation of chiral nanoparticles in macroscopic scale within a microfluidic channel.

In this Letter, we have proposed an all-optical scheme for chiral particle separation with a microcylinder-pair system (MCPS) with a micrometer scale channel, applicable in microfluidic environments. By illuminating the MCPS with two counter-incident plane waves of orthogonal polarization, the electromagnetic chirality gradient can be generated. The MCPS can also enhance chirality-dependent lateral optical forces of the coupled fields so that the setup can shift trapping equilibrium positions for opposite-handedness nanoparticles and make the sideways motion observable.

Significance of plasma TGF-β1 level detection in patients with T2DM with heart failure.

Background: The aim of the study was to examine the significance of plasma Transforming Growth Factor-1/TGF-β1 (TGF-β1) level testing in patients with Type 2 Diabetes Mellitus (T2DM) and heart failure.

Methods: A sample of T2DM patients who were hospitalised for dyspnea was chosen between June 2021 and June 2023. Based on the convenience sample approach, 150 cases were screened for the study, and 50 healthy non-diabetic people without cardiac problems who completed physical examinations over the same period were included as a control group.

Modeling and optimization of culture media for recombinant vaccine antigen HpaA.

Introduction: () infection represents a significant global health concern, exacerbated by the emergence of drug-resistant strains resulting from conventional antibiotic treatments. Consequently, the development of vaccines with both preventive and therapeutic properties has become crucial in addressing infections. The adhesin protein HpaA has demonstrated strong immunogenicity across various adjuvants and dosage forms, positioning it as a key candidate antigen for recombinant subunit vaccines against .

Longitudinal relationships between physical activity, body appreciation, and proactive coping in college students: A cross-lagged panel model.

Previous studies have found a significant relationship between physical activity and proactive coping, but the directionality of the relationship and its underlying mechanisms remain unclear. The present study examined the longitudinal relationships between physical activity, proactive coping, and body appreciation. A total of 376 college students (265 males, 111 females; M = 22.

Posttransplant complications: molecular mechanisms and therapeutic interventions.

Posttransplantation complications pose a major challenge to the long-term survival and quality of life of organ transplant recipients. These complications encompass immune-mediated complications, infectious complications, metabolic complications, and malignancies, with each type influenced by various risk factors and pathological mechanisms. The molecular mechanisms underlying posttransplantation complications involve a complex interplay of immunological, metabolic, and oncogenic processes, including innate and adaptive immune activation, immunosuppressant side effects, and viral reactivation.

Lewis Base-Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic Chlorosilanes Route to -Stereogenic Silylethers.

Enantiopure -stereogenic organosilanes are highly valued in the fields of organic synthesis, development of advanced materials, and drug discovery. However, they are not naturally occurring, and their synthesis has been largely confined to resolution of racemic silanes or desymmetrization of symmetric silanes. In contrast, the dynamic kinetic asymmetric transformation (DYKAT) of racemic organosilanes offers a mechanistically distinct approach and would broaden the accessibility of -stereogenic silanes in an enantioconvergent manner.

MXene-Based Skin-Like Hydrogel Sensor and Machine Learning-Assisted Handwriting Recognition.

Conductive hydrogels are widely used in flexible sensors owing to their adjustable structure, good conductivity, and flexibility. The performance of excellent mechanical properties, high sensitivity, and elastic modulus compatible with human tissues is of great interest in the field of flexible sensors. In this paper, the functional groups of trisodium citrate dihydrate (SC) and MXene form multiple hydrogen bonds in the polymer network to prepare a hydrogel with mechanical properties (Young's modulus (23.

Smartphone-assisted fluorescent sensor for the visualization and quantitative detection of doxycycline and L-arginine.

A novel smartphone-assisted fluorescent sensor based on europium/zirconium metal-organic framework (Eu/Zr-MOF) was developed for the fast and sensitive determination of doxycycline (DOX) and L-arginine (Arg). After the addition of DOX, the fluorescence of Eu/Zr-MOF was quenched owing to the inner filter effect (IFE). When Arg was introduced into the Eu/Zr-MOF@DOX complex system, the fluorescence was recovered because the interaction between Arg and Eu/Zr-MOF@DOX weakened the IFE.

Fatigue Analysis of Composite Bolted Joints under Random and Constant Amplitude Fatigue Loadings.

This paper attempts to analyze the random fatigue life and failure modes of joints using two calculation methods. Three kinds of tests were carried out, which were the static test, constant amplitude fatigue test and the random fatigue test, and four kinds of joints were designed. After the static test, the joint was subjected to a constant amplitude fatigue test by selecting different percentages of load according to the static strength.

Microsphere lens array embedded microfluidic chip for SERS detection with simultaneous enhancement of sensitivity and stability.

Surface enhanced Raman spectroscopy (SERS) utilizes the fingerprint features of molecular vibrations to identify and detect substances. However, in traditional single focus excitation scenarios, its signal collection efficiency of the objective is restricted. Furthermore, the uneven distribution of samples on the SERS substrate would result in poor signal stability, while the excitation power is limited to avoid sample damage.

Attenuating bone loss in osteoporosis: the potential of corylin (CL) as a therapeutic agent.

The global prevalence of osteoporosis is being exacerbated by the increasing number of aging societies and longer life expectancies. In response, numerous drugs have been developed in recent years to mitigate bone resorption and enhance bone density. Nonetheless, the efficacy and safety of these pharmaceutical interventions remain constrained.

I prefer what you can see: The role of visual perspective-taking on the gaze-liking effect.

Individuals' gaze on an object usually leads others to prefer that object, which is called the gaze-liking effect. However, it is still unclear whether this effect is driven by social factors (i.e.

Melanin-like nanoparticles alleviate ischemia-reperfusion injury in the kidney by scavenging reactive oxygen species and inhibiting ferroptosis.

Kidney transplantation is essential for patients with end-stage renal disease; however, ischemia-reperfusion injury (IRI) during transplantation can lead to acute kidney damage and compromise survival. Recent studies have reported that antiferroptotic agents may be a potential therapeutic strategy, by reducing production of reactive oxygen species (ROS). Therefore, we constructed rutin-loaded polydopamine nanoparticles (PEG-PDA@rutin NPs, referred to as PPR NPs) to eliminate ROS resulting from IRI.

Strength and Failure Analysis of Fiber-Wound Composite Gas Cylinder via Numerical Simulation.

Based on the classical grid theory and related regulations, a structure model of a fiber-wound composite gas cylinder was designed in this paper. Based on the design results, a finite element model of a fully wound composite cylinder of an aluminum alloy inner liner with a working pressure of 35 MPa was established based on the ABAQUS software, and its stress distribution under working pressure and minimum burst pressure was analyzed. According to engineering experience, the pressure tolerance of composite cylinders can be improved by proper autofrettage pressure before working pressure, so the influence of autofrettage pressure was analyzed in this paper.