Development and validation of a predictive model and tool for functional recovery in patients after postero-lateral interbody fusion.

Objective: The postoperative recovery of patients with lumbar disc herniation (LDH) requires further study. This study aimed to establish and validate a predictive model for functional recovery in patients with LDH and explore associated risk factors.

Method: Patients with LDH undergoing PLIF admitted from January 1, 2018 to December 31, 2022 were included, and patient data were prospectively collected through follow-up.

Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei Province.

To investigate the population distribution characteristics of elderly osteoporosis fracture patients in Hebei Province and analyze the effects of air pollutants on elderly osteoporosis fractures, We retrospectively collected 18,933 cases of elderly osteoporosis fractures from January 1, 2019, to December 31, 2022, from four hospitals in Hebei Province. The average age was 76.44 ± 7.

Expression, prognosis, immunological infiltration, and DNA methylation of members of the SFRP gene family in colorectal cancer: a comparative bioinformatic and experimental analysis.

This study aimed to investigate the expression, prognostic significance, methylation, and immune invasion levels of secreted frizzled-related proteins (SFRP1-5) in colorectal cancer (CRC). Additionally, the relationship between SFRP1/2 methylation and immune infiltration in CRC was explored. The expression of SFRP1-5 was analyzed using several databases, including GEO, TCGA, TIMER, STRING, and GEPIA.

The adjuvant effect of manganese on tuberculosis subunit vaccine Bfrb-GrpE.

Protein subunit vaccines, lacking pathogen-associated molecular patterns that trigger immune responses, rely on adjuvants to induce robust immune responses against the target pathogen. Thus, selection of adjuvants plays a crucial role in the design of protein subunit vaccines. Recently, there has been growing interest in utilizing cGAS-STING agonists as vaccine adjuvants.

Characteristics of In-Flight Medical Emergencies on a Commercial Airline in Mainland China: Retrospective Study.

Background: In-flight medical emergencies (IMEs) can have severe outcomes, including the deaths of passengers and aircraft diversions. Information is lacking regarding the incidence rate and characteristics of IMEs in most countries, especially in mainland China.

Objective: The objective of this study was to investigate the incidence, patterns, and associated risk factors of IMEs in mainland China and to provide medical suggestions for the evaluation and management of IMEs.

Carotenoid Cleavage Dioxygenase Gene Enhances Tanshinone Accumulation and Drought Resistance in .

Danshen ( Bunge) is a perennial herbaceous plant of the Salvia genus in the family Lamiaceae. Its dry root is one of the important traditional Chinese herbal medicines with a long officinal history. The yield and quality of are influenced by various factors, among which drought is one of the most significant types of abiotic stress.

Phase II study of perioperative camrelizumab and XELOX for locally advanced gastric or gastroesophageal junction adenocarcinoma.

Immune checkpoint inhibitors combined with chemotherapy have shown promising efficacy in treating gastric or gastroesophageal junction (G/GEJ) adenocarcinoma in the neoadjuvant setting. This phase II trial (NCT05715632) aimed to investigate the efficacy and safety of perioperative camrelizumab plus XELOX in patients with locally advanced G/GEJ adenocarcinoma. Treatment-naive patients with cT3-4aN1-3 M0 resectable locally advanced G/GEJ adenocarcinoma were recruited to receive camrelizumab (200 mg, intravenously) on Day 1 combined with XELOX (oxaliplatin at 130 mg/m on Day 1 and capecitabine at 1000 mg/m on Days 1-14) every 3 weeks for four cycles, followed by surgery and adjuvant camrelizumab combined with XELOX every 3 weeks for four cycles.

Synthesis of Clickable Isotactic Poly(vinyl ether)s through Organocatalytic Stereoselective Cationic Copolymerization.

By virtue of the high reliability of click chemistry, polymers with clickable groups provide a useful platform for the rapid synthesis of polymer materials with diverse functionalities and architectures. However, the polymerization of clickable vinyl monomers with a concurrent regulation on tacticity remains underdeveloped. Herein, we report the successful development of a stereoselective cationic copolymerization of C-C triple bond-containing vinyl ethers with simple alkyl vinyl ethers by employing confined Brønsted acid as catalyst, which allows for the synthesis of alkyne-functionalized vinyl ether copolymers with high isotacticity (up to 90 % m), controlled molecular weight, and variable content of C-C triple bonds.

Metagenomic analysis of the dichotomous role of uranium in regulating intracellular and extracellular antibiotic resistance genes in activated sludge.

Antibiotic resistance genes (ARGs) in activated sludge include intracellular ARGs (iARGs) and extracellular ARGs (eARGs), both of which are recognized as emerging pollutants. While the activated sludge process has been commonly considered for treating wastewater contaminated with radionuclide, the effects and mechanisms of radioactive heavy metals on the fate of iARGs and eARGs (i/e-ARGs) in activated sludge are largely elusive. Here, the distribution, mobility, and hosts of i/e-ARGs in activated sludge during environmental concentrations (50 μg/L and 5000 μg/L) of radioactive uranium (U) stress were explored via metagenomics.

Metagenomic insight into the enrichment of antibiotic resistance genes in activated sludge upon exposure to nanoplastics.

Activated sludge is an important reservoir for the co-occurring emerging contaminants including nanoplastics (NPs) and antibiotic resistance genes (ARGs). However, the impacts and potential mechanisms of NPs on the fate of ARGs in activated sludge are not fully understood. Herein, we used metagenomic approach to investigate the responses of ARGs, host bacteria, mobile genetic elements (MGEs), and functional genes to polystyrene (PS) NPs at environmentally relevant (0.

How do environmental stressors influence migration? A meta-regression analysis of environmental migration literature.

Background: The amount of literature on environmental migration is increasing. However, existing studies exhibit contradictory results. A systematic synthesis of the environment-migration relationship is much needed.

Clinical Characteristics and Outcomes in Patients with Ruptured Middle Cerebral Artery Aneurysms: A Multicenter Study in Northern China.

Introduction: The long-term prognosis of ruptured middle cerebral artery aneurysms (MCAAs) in northern China remains unclear. The aim of this study is to analyze the epidemiological characteristics and long-term outcomes of ruptured MCAAs in northern China.

Methods: We included patients who were consecutively admitted for ruptured MCAAs to 12 tertiary care centers in northern China from January 2017 to December 2020.

Emerging Applications of Image Post-Processing 3D Visualisation for Cerebrovascular Diseases.

Intracranial vascular-related diseases are a common occurrence in neurosurgery. They have complex and diverse pathogeneses; further, their diagnosis and treatment remain unclear. Three-dimensional image post-processing technology is an emerging technology that involves converting a brain image scan into a digital model using image post-processing software, thus establishing a 3D view of the region of interest.

Apelin regulates mitochondrial dynamics by inhibiting Mst1-JNK-Drp1 signaling pathway to reduce neuronal apoptosis after spinal cord injury.

In the secondary injury stage of spinal cord injury, mitochondrial dysfunction leads to decreased ATP production, increased ROS production, and activation of the mitochondria-mediated apoptosis signaling pathway. This ultimately intensifies neuronal death and promotes the progression of the injury. Apelin, a peptide produced by the APLN gene, has demonstrated promise in the treatment of spinal cord injury.

Single Molecular Dispersion of Crown Ether-Decorated Cobalt Phthalocyanine on Carbon Nanotubes for Robust CO Reduction through Host-Guest Interactions.

Immobilizing molecular catalysts on electro-conductive supports (for example, multi-walled carbon nanotubes, CNTs) represent a promising way to well-defined catalyst/support interfaces, which has shown appreciable performance for catalytic transformation. However, their full potential is far from achieved due to insufficient utilization of the intrinsic activity for each immobilized molecular catalyst, especially at loadings that should allow decent current densities. In the present work, we discover host-guest interaction between tetra-crown ether substituted cobalt phthalocyanine and metal ions, for example K ions, not only eliminate catalyst aggregation at immobilization procedures but also reinforce catalyst/support interactions by additional electrostatic attractions under operational conditions.

An Efficient Approach for Advancing Performance in Rapid Detection Based on Molybdenum Disulfide Nanoflower Supported Binary Transition Metal Oxides.

Binary transition metal oxides (BTMOs) have drawn considerable attention in recent years for their excellent catalytic properties and chemical stability in the sensing field. Regrettably, the loss of active site exposure originating from the agglomerate during preparation largely restricted their sensing applications. In this work, we report an efficient strategy for advancing the performance of BTMOs in rapid detection based on a 3D molybdenum disulfide nanoflower.

Relocation preference and settlement: Lessons from the Poverty Alleviation Relocation Program in China.

We explored the linkages between socioeconomic and demographic factors, relocation preference, and settlement associated with China's Poverty Alleviation Relocation Program. Using multivariate ordinal logistic regression, panel data modeling, and multilevel methods, we found that outdated infrastructure at places of origin, such as long distances to paved roads or elementary schools, increased the probability of relocation, and the presence of left-behind household members at the origin compromised re-settlement. This study sheds light on the community- and household-level factors that influence relocation preference and settlement, offering valuable insights for future research and informing the design and implementation of relocation projects.

Prevalence Characteristics of Osteoporosis Fractures in the Elderly in Two Regions of China and Analysis of the Lag Effect of Air Pollutants on them.

Objective: Air pollution is increasing and threatening human health. The objective of this study is to investigate the population distribution characteristics of elderly osteoporosis fractures in Hebei Province and Xinjiang Uygur Autonomous Region and to analyze the effects of air pollutants on the number of elderly osteoporosis fracture inpatients in the two regions.

Method: A retrospective collection of elderly osteoporosis fracture cases was conducted in selected hospitals in Hebei Province and Xinjiang Uygur Autonomous Region from January 1, 2018 to December 31, 2022.

Short- and long-term impacts of the National Essential Medicines Policy on drug availability, price, and usage in a deprived rural county in southwestern China: an interrupted time series analysis across 8 years.

Background: China's National Essential Medicines Policy (NEMP) has been implemented for over 15 years; yet empirical evidence on its long-term impacts is lacking, particularly in remote and rural regions. This study aims to assess the short-and long-term effects of NEMP on the drug availability, price, and usage in a deprived rural county in southwestern China.

Methods: A quasi-experimental design was employed, featuring a single-group pre-and-post comparison.

Unveiling the role of uranium in enhancing the transformation of antibiotic resistance genes.

Transformation represents one of the most important pathways for the horizontal transfer of antibiotic resistance genes (ARGs), which enables competent bacteria to acquire extracellular ARGs from the surrounding environment. Both heavy metals and irradiation have been demonstrated to influence the bacterial transformation process. However, the impact of ubiquitously occurring radioactive heavy metals on the transformation of ARGs remains largely unknown.

A Comprehensive Survey on Visual Perception Methods for Intelligent Inspection of High Dam Hubs.

There are many high dam hubs in the world, and the regular inspection of high dams is a critical task for ensuring their safe operation. Traditional manual inspection methods pose challenges related to the complexity of the on-site environment, the heavy inspection workload, and the difficulty in manually observing inspection points, which often result in low efficiency and errors related to the influence of subjective factors. Therefore, the introduction of intelligent inspection technology in this context is urgently necessary.

The Changes of Microbial Diversity and Isolation of Microorganism in Soil for Alleviating the Production Decreasing After Continuous Cultivation of Ganoderma lucidum.

Ganoderma lucidum is a medicinal mushroom usually cultivated in logs and covered with soil. Its production decreases after continuous cultivation. Changes of microbial diversity in soil are suggested to be one of the reasons.

A dual-center study: can ultrasound radiomics differentiate type I and type II epithelial ovarian cancer patients with normal CA125 levels?

Objective: CA125 is recommended by many countries as the primary screening test for ovarian cancer. But there are patients with ovarian cancer having normal CA125. We hope to identify the types of EOC with normal CA125 levels better by building a refined model based on the ultrasound radiomics, thus providing precise medical treatment for patients.