Hybrid biological macromolecules spider-silk fibroin optical patches for efficient wound healing.

Efforts toward developing wound dressings that effectively monitor healing have become at the forefront of the field of wound healing. However, monofunctionality, biotoxicity, and passive therapy constrain wound patches. Herein, a hypoallergenic wound patch integrating moisture monitoring, motion sensing and electrical stimulation for wound healing is presented.

Remimazolam attenuates lipopolysaccharide-induced neuroinflammation and cognitive dysfunction.

Objective: Remimazolam, a novel benzodiazepine, is widely used as an anesthetic in endoscopic procedures; however, its effects on cognitive function remain unclear, limiting its broader application in general anaesthesia. Neuroinflammation is a well-established key factor in the etiology and progression of cognitive dysfunction, including conditions such as Alzheimer's disease, Parkinson's disease, postoperative delirium, and postoperative cognitive dysfunction. Preclinical studies have demonstrated that remimazolam exerts anti-inflammatory and neuroprotective effects, and clinical reports indicate a reduced incidence of postoperative delirium in patients treated with remimazolam.

Tetracycline and quinolone contamination mediate microbial and antibiotic resistant gene composition in epiphytic biofilms of mesocosmic wetlands.

The fate and ecological impact of antibiotics on aquatic ecosystems have not been properly elucidated in mesocosm wetlands scale. This study explored how tetracyclines (TCs, including tetracycline TC and oxytetracycline) and fluoroquinolones (QNs, including ciprofloxacin CIP and levofloxacin) affect mesocosm wetlands vegetated by V. spiralis, focusing on their impact on epiphytic biofilm microbial communities and antibiotic resistance genes (ARGs).

A framework integrating affinity propagation algorithm and spatial bivariate analysis for enhanced identification and localisation of soil heavy metals pollution sources.

The accurate identification of pollutant sources and their spatial distribution is crucial for mitigating soil heavy metals (SHMs) pollution. However, the receptor model struggles to effectively categorize pollutant sources and pinpoint their locations and dispersion trends. We propose a novel comprehensive framework that combines a receptor model, random forest (RF), affinity propagation (AP) algorithm, and bivariate local indicator of spatial association (BLISA), to optimize the traditional approach for tracing SHMs sources in industrial regions.

Fine-scale genomic analysis of the tree endophyte sp. FPYF3050 producing monoterpene 1,8-cineole.

1,8-Cineole has a potential in control crop pests and biofuels. The endophytic fungus, sp. FPYF3050 (), can produce over 90% 1,8-cineole of relative area in its natural volatiles, possessed nematicide properties.

[Characterization and expression optimization of a highly thermostable hexokinase in ].

Hexokinase is a crucial diagnostic reagent in blood glucose testing, which has high requirements for the enzyme activity and thermal stability. The hexokinases in China mainly rely on imports and are primarily sourced from yeast, with high costs and poor thermal stability, which limit the development of blood glucose diagnostic reagents. Therefore, there is an urgent need for the efficient expression of highly active and thermally stable hexokinases.

Electroacupuncture promotes angiogenesis by regulating miR-142-5p and activating ADAMTS1/PI3K/AKT pathway in ischemic stroke rats.

Objectives: To observe the effect of electroacupuncture on miR-142-5p and ADAMTS1/PI3K/AKT pathway in rats with ischemic stroke, so as to explore the regulatory mechanism of electroacupuncture on angiogenesis after ischemic stroke.

Methods: This study was divided into two parts. The first part of the experiment：SD rats were randomly divided into sham operation group, model group and electroacupuncture group.

Pig-to-human kidney xenotransplants using genetically modified minipigs.

This study develops an observational model to assess kidney function recovery and xenogeneic immune responses in kidney xenotransplants, focusing on gene editing and immunosuppression. Two brain-dead patients undergo single kidney xenotransplantation, with kidneys donated by minipigs genetically modified to include triple-gene knockouts (GGTA1, β4GalNT2, CMAH) and human gene transfers (hCD55 or hCD55/hTBM). Renal xenograft functions are fully restored; however, immunosuppression without CD40-CD154 pathway blockade is ineffective in preventing acute rejection by day 12.

Urinary Sodium Excretion and Kidney Disease Progression in IgA Nephropathy: A Cohort Study.

Introduction: The role of dietary sodium intake in the risk of chronic kidney disease progression remains controversial. This study aimed to evaluate the association of urinary sodium excretion and progression of IgA nephropathy.

Methods: We assessed 596 patients with IgA nephropathy, and urinary sodium excretion was measured at the time of kidney biopsy.

One-Pot, Solvent Free Synthesis of 2,5-Furandicarboxylic Acid from Deep Eutectic Mixtures of Sugars as Mediated by Bifunctional Catalyst.

Currently one-pot conversion of sugars to 2,5-furandicarboxylic acid (FDCA) is of significant interest due to the attainability of sugars as a feedstock and the enormous potential of FDCA as a bioplastic monomer. However, it remains challenging to construct efficient catalysts for this process. In this study, CoO species were anchored to a sulfonated covalent organic framework thus affording a bifunctional catalyst (CoO@COF-SOH).

Unraveling the regulatory cell death pathways in gastric cancer: a multi-omics study.

Gastric cancer (GC) is a prevalent form of cancer worldwide and has a high death rate, with less than 40% of patients surviving for 5 years. GC demonstrates a vital characteristic of evading regulatory cell death (RCD). However, the extent to which RCD patterns are clinically significant in GC has not been well investigated.

Spatial and temporal dynamics of sewage sludge phosphorus recovery potential in the cities of Yangtze River Zone in China: Implications for regional recycling policies.

Sewage sludge phosphorus (P) recovery presents opportunities to sustainably recycle P from cities to agriculture and alleviate global P scarcity. However, limited research explores sustainable recovery targets considering spatial-temporal variations in sludge generation and implications based on city-level local P demand. This study analyzed sludge production form 2009-2021 across 130 cities in China's Yangtze River Zone, which increased by almost 35 % from 2009 to 2021.

Structure and physicochemical properties of rice starch modified with dodecenyl succinic anhydride and its use for microencapsulating Pediococcus acidilactici probiotic.

Polysaccharides are used as wall materials to extend the shelf life of lactic acid bacteria. Ice crystal formation during freezing leads to probiotic death. We prepared a series of dodecenyl succinic anhydride (DDSA)-modified rice starches with varying degrees of substitution and compared their functional properties.

Navigating the personal carbon inclusion scheme: An evolutionary game theory approach to low-carbon behaviors among socio-economic groups.

In response to the challenges posed by climate change, China has launched the Personal Carbon Inclusion (PCI) scheme to encourage individuals to transition towards low-carbon lifestyles. This study investigates the behaviors of participants within the PCI scheme using a tripartite evolutionary game model, encompassing high-income and low-income individuals, as well as the PCI platform itself. The research analyzes participants' strategies, examines the evolutionary stability of different strategies, and assesses the robustness of equilibrium points within the game dynamics.

MicroRNA-29b Plays a Vital Role in Podocyte Injury and Glomerular Diseases through Inducing Mitochondrial Dysfunction.

Diabetic kidney disease (DKD) is becoming the most leading cause of end-stage renal disease (ESRD). Podocyte injury plays a critical role in DKD progression. Notably, mitochondrial dysfunction is crucial for podocyte injury.

Role of naringin in the treatment of atherosclerosis.

Atherosclerosis (AS) is a major pathological basis of coronary heart disease. However, the currently available medications are unable to effectively reduce the incidence of cardiovascular events in the majority of patients with AS. Therefore, naringin has been attracting considerable attention owing to its anti-AS effects.