Comparative analysis of epidemiological and Spatiotemporal patterns in seasonal influenza and COVID-19 outbreaks.

The aim of this study was to gain insights into the epidemiology, spatial trends, spatial structure evolution, and spatiotemporal aggregation characteristics of influenza epidemics during seasonal influenza and COVID-19 pandemic in Fuzhou from 2013 to 2022. Utilizing influenza case report data from Fuzhou spanning 2013 to 2022, we applied descriptive epidemiological methods to analyze the epidemiological characteristics and distribution patterns of reported influenza cases across various time periods, populations, and regions. Furthermore, we employed trend-surface analysis, kernel density estimation, and space-time scanning statistics to investigate the evolution of spatial trends, changes in spatial structure, and the spatiotemporal aggregation characteristics of the reported influenza incidence rate at the county level.

From genetic disposition to academic achievement: The mediating role of non-cognitive skills across development.

Genetic effects on academic achievement are likely to capture environmental, developmental, and psychological processes. How these processes contribute to translating genetic dispositions into observed academic achievement remains critically under-investigated. Here, we examined the role of non-cognitive skills-e.

A Modified Method for Intrathecal Catheterization in Rats.

Intrathecal catheterization has been widely applied in animal experiments, especially those on neuropathic pain. However, the traditional methods still have several limitations. Although some investigators have attempted to improve the traditional methods, the available methods still need to be modified.

Development and application of multivalent nanobody-functionalized plasmonic probes in SERS sensing platforms.

Surface-enhanced Raman scattering (SERS) immunoassays have emerged as highly sensitive, multiplexed analytical techniques for detecting protein biomarkers. Traditional SERS immunoassays typically rely on antibody-based SERS probes for target protein detection; however, it is challenging to obtain antibodies that are both highly effective at identifying natural proteins and suitable for SERS probe conjugation. Herein, we engineer a MultiValent Probe (MVP), consisting of multivalent nanobodies as the protein-targeting ligand to provide improved binding avidity and Raman reporter-coated gold-silver alloy nanoboxes for single-particle signal readouts.

Impact of Paraspinal Sarcopenia on Clinical Outcomes in Intervertebral Disc Degeneration Patients Following Percutaneous Transforaminal Endoscopic Lumbar Discectomy.

Objective: The paraspinal muscles are a crucial component of the spine's extrinsic stabilization system. While the impact of paraspinal muscle sarcopenia on patient-reported outcome measures (PROMs) after lumbar surgery is well known, its effects following percutaneous transforaminal endoscopic discectomy (PTED) have not been investigated. To investigate the prognostic value of preoperative paraspinal sarcopenia on long-term PROMs after PTED, and to identify independent predictors of chronic postoperative low back pain.

Three-Dimensional Quantitative Structure-Activity Relationship-Based Molecular Design through a Side Arm Strategy to Synthesize Phenylpyrazole Oxime Derivatives and Improve Their Insecticidal Activity and Photoself-Degradation.

Three-dimensional quantitative structure-activity relationship (3D-QSAR) serves as one of the most important and effective tools to guide molecular design for the development of new pesticides. According to the principle of structural splicing, only changing a small group may lead to a great increase in activity while maintaining the active center unchanged. Under the guidance of 3D-QSAR, three series of phenylpyrazole oxime fluorescent insecticides acting on the GABA receptor, namely, esters (), ethers (), and triazoles (), were designed through a side arm strategy and synthesized by an ultrasonic bath reaction, which were fully characterized and crystal-analyzed.

Targeted shortwave diathermy combined with perceptual training for patients with severe traumatic optic neuropathy.

Background: Patients with severe traumatic optic neuropathy (TON) often show limited improvement in visual function despite therapy.

Objective: This study aims to investigate whether targeted shortwave diathermy (SWD) combined with perceptual training enhances visual function in patients with severe TON following endoscopic optic nerve decompression (EOND) surgery.

Methods: Forty patients with severe TON after EOND surgery were randomly assigned to either the rehabilitation (Reh) group ( = 24) or the non-rehabilitation (Nreh) group ( = 16).

Sialic acid metabolism-based classification reveals novel metabolic subtypes with distinct characteristics of tumor microenvironment and clinical outcomes in gastric cancer.

Background: High heterogeneity in gastric cancer (GC) remains a challenge for standard treatments and prognosis prediction. Dysregulation of sialic acid metabolism (SiaM) is recognized as a key metabolic hallmark of tumor immune evasion and metastasis. Herein, we aimed to develop a SiaM-based metabolic classification in GC.

Intelligent anti-jamming decision algorithm for wireless communication under limited channel state information conditions.

Deep reinforcement learning has been widely applied to solve the anti-jamming problems in wireless communications, achieving good results. However, most research assumes that the communication system can obtain complete Channel State Information (CSI). Under limited CSI conditions, this paper models the system using Partially Observable Markov Decision Processes (POMDPs).

Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis.

Background: The existing drugs for ovarian cancer (OC) are unsatisfactory and thus new drug targets are urgently required. We conducted proteome-wide Mendelian randomization (MR) and colocalization analysis to pinpoint potential targets for OC.

Methods: Data on protein quantitative trait loci (pQTL) for 734 plasma proteins were obtained from large genome-proteome-wide association studies.

Risk effects of environmental factors on human brucellosis in Aksu Prefecture, Xinjiang, China, 2014-2023.

The context of rapid global environmental change underscores the pressing necessity to investigate the environmental factors and high-risk areas that contribute to the occurrence of brucellosis. In this study, a maximum entropy (MaxEnt) model was employed to analyze the factors influencing brucellosis in the Aksu Prefecture from 2014 to 2023. A distributed lag nonlinear model (DLNM) was employed to investigate the lagged effect of meteorological factors on the occurrence of brucellosis.

Photoinduced radical cyclization reaction of isocyanides with α-carbonyl bromides to access 11-alkyl-substituted 1,4-dibenzodiazepines.

1,4-Dibenzodiazepines, an important component of nitrogen-containing heterocycles, are widely present in drugs. Herein, we developed a photochemical radical cascade cyclization reaction of isocyanides with α-carbonyl bromides under mild conditions. A sequence of 11-alkyl-substituted 1,4-dibenzodiazepines were produced in 53%-85% yields, demonstrating excellent tolerance towards various functional groups.

Triptolide exhibits dual anti-tumor effects through inhibiting autophagy and extracellular matrix activation in pancreatic cancer.

Aim: The tumor microenvironment in pancreatic cancer, characterized by abundant desmoplastic stroma, has been implicated in the failure of chemotherapy. Therefore, developing therapeutic strategies targeting tumor and stromal cells is essential. Triptolide, a natural compound derived from the plant Tripterygium wilfordii, has shown antitumor activity in various cancers, including pancreatic cancer.

Erythrocyte Fatty Acid Patterns Are Associated with Skeletal Muscle Mass in Chinese Children.

Background: Nutritional factors are important for skeletal muscle mass and grip strength development in children.

Objectives: This study aimed to investigate the relationship between erythrocyte membrane fatty acid patterns (FAPs) and skeletal muscle mass and grip strength in children.

Methods: A total of 452 children aged 6-9 y were included in this study.

Quinoa is more effective than other whole grains in the management of impaired glucose tolerance: a randomized controlled trial.

The purpose of this study was to compare the effects of quinoa multigrain supplementation on glycemia and lipid metabolism among individuals with impaired glucose tolerance (IGT). In total, 207 participants diagnosed with IGT were randomly assigned to the quinoa group (QG; 100 g day, replacing about half of the total daily staple food), multiple whole grain group (WGG; 100 g day), or control group (CG) and followed for one year. Biomarkers were measured before and after the intervention.

Low-Energy Delicate Pulsed Light Therapy for Sensitive Skin: A Retrospective Study.

Background: Sensitive skin (SS) is a multifactorial syndrome that affects about half of the world's population. However, there is no standardized treatment protocol. Photovoltaic technology has been widely used in recent years for the treatment of sensitive skin, but the efficacy of low-energy delicate pulsed light (DPL) in the treatment of sensitive skin is unknown.

Exosome-based therapies for inflammatory disorders: a review of recent advances.

Exosomes, small extracellular vesicles secreted by cells, have emerged as focal mediators in intercellular communication and therapeutic interventions across diverse biomedical fields. Inflammatory disorders, including inflammatory bowel disease, acute liver injury, lung injury, neuroinflammation, and myocardial infarction, are complex conditions that require innovative therapeutic approaches. This review summarizes recent advances in exosome-based therapies for inflammatory disorders, highlighting their potential as diagnostic biomarkers and therapeutic agents.

Evidence for clonal integration of clones contributing to unexpectedly higher benefits for interspecific neighbours.

Clonal plants benefit from the ability to translocate resources among interconnected ramets to colonize stress habitats. Despite the fact that the physiological integration of clones may influence their general performance and competitiveness, we still lack an understanding of how integration alters the ability of clones to compete with their neighbours. In a greenhouse experiment, we investigated how clonal integration of a perennial herbaceous Cynodon dactylon, which originated from two flooding stress ecotypes, influenced the growth, functional traits, biomass allocation and relative competitiveness of their intraspecific and interspecific neighbours.

Comparative Metabolic Defense Responses of Three Tree Species to the Supplemental Feeding Behavior of .

L. can attract adult Asian longhorned beetle (ALB), (Motschulsky), and kill their offspring by gum secretion in oviposition scars. This plant has the potential to be used as a dead-end trap tree for ALB management.

Causal relationship between mitochondrial function and delirium: a bidirectional two-sample Mendelian randomisation analysis.

Background: Previous studies have suggested a potential link between delirium and mitochondrial function. Consequently, this Mendelian randomisation (MR) study aimed to further investigate their causal relationship.

Methods: In this bidirectional MR study, the relationship between 73 proteins related to mitochondrial function and delirium, including delirium not induced by alcohol or other psychoactive substances (DEL) and delirium associated with alcohol withdrawal (AL-DEL).

Chinese Visceral Adipose Index is Associated with Arterial Stiffness in Type 2 Diabetes Patients: A Cross-Sectional Study.

Purpose: The purpose of this study is to investigate the association between Chinese Visceral Adipose Index(CVAI) and brachial-ankle pulse wave velocity (baPWV) in type 2 diabetes (T2D) patients, in order to provide scientific evidence for the prevention and treatment of macrovascular complications in T2D.

Patients And Methods: This research adopts the cross-sectional study design. Anthropometric assessment, baPWV assessment and biochemical assessment were performed in 2906 T2D patients.

Crystal OH mediating pathway for hydrogen peroxide production via two-electron water oxidation in non-carbonate electrolytes.

Water oxidation presents a promising avenue for hydrogen peroxide (HO) production. However, the reliance on alkaline bicarbonate electrolytes as an intermediate has limitations, such as HO decomposition and a narrow pH effectiveness range (7-9), restricting its utility across wider pH ranges. This study unveils a crystal OH mediating pathway that stabilizes SOOH* as a crucial intermediate.

Multicolor and sign-invertible circularly polarized luminescence from nonchiral charge-transfer complexes assembled with N-terminal aromatic amino acids.

Circularly polarized luminescence (CPL) materials with precisely controlled emission colors and handedness are highly desirable for their promising applications in advanced optical technologies, but it is rather challenging to obtain them primarily due to the lack of convenient, powerful, and universal preparation strategies. Herein, we report a simple yet versatile solution route for constructing multicolor CPL materials with controllable handedness from nonchiral luminescent charge-transfer (CT) complexes through co-assembly with chiral N-terminal aromatic amino acids. The resulting ternary co-assemblies exhibit obvious CPL signals from 489 to 601 nm, covering from blue green and yellow to orange-red.

CrackNet: A Hybrid Model for Crack Segmentation with Dynamic Loss Function.

Cracks are a common form of damage in infrastructure, posing significant risks to both personal safety and property. Along with the development of deep learning, visual-based crack automatic detection has been widely studied. However, this task is still challenging due to complex crack topology, noisy backgrounds, unbalanced categories, etc.