Mechanisms of the formation of acquired drought tolerance in wheat: insights from combining high-throughput phenotyping and genome-wide association study.

Drought priming, a potential strategy to bolster wheat yield amidst recurring droughts. Identifying the responsive cultivars and deciphering the underlying mechanisms are vital to better activate the instinct of plants coping with drought stress. Here, responses of 157 wheat cultivars to drought priming were phenotyped using a high-throughput phenotyping (HTP) platform across two wheat-growing seasons.

Effect of polysaccharides and saponins from Polygonatum kingianum against uranium-induced renal injury in rats.

Uranium poisoning is increasingly recognized as a public health issue. Polygonatum kingianum (PK) is valued for its therapeutic properties and food applications. Original research showed PK aqueous extract (PKAE) and polysaccharides (PKP) could alleviate uranium-induced cytotoxicity in vitro.

Multimodal ultrasound assessment for monitoring keloid severity and treatment response.

The current understanding and a standardized assessment or treatment guidelines for keloids are not fully established, highlighting the need for an objective method to gauge keloid severity and treatment outcomes. This study investigated the clinical utility of multimodal ultrasound, integrating Shear Wave Elastography (SWE) and Angio planewave ultrasensitive imaging (AP), to assess keloid severity and treatment responses in 58 keloids across 31 patients. Keloids were categorized into mild, moderate, and severe based on Vancouver Scar Scale (VSS) scores.

Selenium-modified hydroxyapatite titanium coating: enhancing osteogenesis and inhibiting cancer in bone invasion by head and neck squamous cell carcinoma.

Introduction: Head and neck squamous cell carcinoma (HNSCC) frequently invades the jaw, and surgical treatment often leads to bone defects requiring reconstruction with titanium plates. To enhance the anti-tumor and bone regeneration properties of titanium, a selenium-modified hydroxyapatite coating was developed on titanium surfaces.

Methods: Selenium-modified hydroxyapatite coatings was fabricated using micro-arc oxidation (MAO).

Effect of substantial lymphovascular space invasion on location of first disease recurrence in surgical stage I endometrioid endometrial adenocarcinoma.

Objective: Lymphovascular invasion can predict nodal spread and recurrence in endometrioid endometrial cancer; however, the impact of lymphovascular invasion quantification on local versus distant recurrence in surgically staged patients has not yet been established.

Methods: This multicenter, retrospective cohort study included surgically staged patients with International Federation of Obstetrics and Gynecology 2009 stage I node-negative endometrioid endometrial cancer. Patients were treated between January 2012 and December 2019 at 2 tertiary cancer centers.

HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma.

Protein acetylation modification plays important roles in various aspects of tumor progression. Ferroptosis driven by lethal lipid peroxidation is closely related to tumor development. Targeting ferroptosis has become a promising strategy.

Periodontitis History Shapes the Early Peri-Implant Microbiome Formation: A Metagenomic Analysis.

Aim: This study aims to investigate the early alterations in microbiome construction and succession around dental implants in both periodontally healthy individuals and patients with a history of periodontitis during the first month after implant-crown placement.

Materials And Methods: Ninety-five subgingival plaque samples were collected from 10 periodontally compromised patients (PCP) and nine periodontally healthy patients (PHP) at four time points with a 1-week interval and analysed using dynamic metagenomic analysis. The study compared the formation and temporal change in the peri-implant microbiome in the PCP and PHP groups during the first month after the implant crown placement.

From Pathophysiology to Treatment: The Role of Ferroptosis in PCOS.

Polycystic ovary syndrome (PCOS) is a prevalent gynecological endocrine and metabolic disorder in women, with an incidence rate of 10-13%. The etiology of PCOS is multifaceted, involving genetic predisposition, environmental influences, lifestyle factors, and endocrine metabolic dysregulation. Iron, a critical mineral, not only plays a role in regulating female physiological functions and the progression of PCOS but also requires careful management to avoid deficiency.

Amino acid metabolism disorder and oxidative stress took part in EGCG alleviating Mn-caused ferroptosis via miR-9-5p/got1 axis.

Manganese (Mn) is not only an essential trace metal element in organisms, but also a water pollutant and damaging aquatic organisms. (-)-epigallocatechin gallate (EGCG), a natural tea polyphenol derived from green tea, may alleviate toxicity caused by environmental pollutants. Kidney is an important organ for excretion and expel toxins.

Diabetes Mellitus and Hyperlipidemia Status Among Hypertensive Patients in the Community and Influencing Factors Analysis of Blood Pressure Control.

To evaluate the prevalence of type 2 diabetes mellitus (T2DM) and hyperlipidemia in hypertensive patients in South China and assess the relationship between these comorbidities and blood pressure control to develop targeted strategies for hypertension management. Data from the 2020 Guangzhou National Basic Public Health Service Program were analyzed using Chi-square tests, t-tests, and logistic regression with R 4.1.

Advances in 3D and 4D Printing of Gel-Based Foods: Mechanisms, Applications, and Future Directions.

This review examines recent advancements in gel-based 3D and 4D food-printing technologies, with a focus on their applications in personalized nutrition and functional foods. It emphasizes the critical role of tunable rheological and mechanical properties in gels such as starch, protein, and Pickering emulsions, which are essential for successful printing. The review further explores 4D food printing, highlighting stimuli-responsive mechanisms, including color changes and deformation induced by external factors like temperature and pH.

Insight into the effect of electric fields on bioremediation of petroleum-contaminated soil: A micro-ecological response.

The voltage gradient plays a crucial role in the process of electro-bioremediation for petroleum-contaminated soil. However, the micro-ecological response mechanisms of relevance have been scarcely documented. This study compared petroleum degradation characteristics, soil physicochemical properties, and bacterial microbiome indicators under 0.

Puerarin combined with insoluble dietary fiber alleviates obesity induced by high-fat diet through regulating the glycerophospholipid metabolism pathway influenced by gut microbiota.

The purpose of this study was to evaluate the combined effects of puerarin (Pue) and insoluble dietary fiber from (HEIDF) on obesity induced by a high-fat diet (HFD) in mice, focusing on their effects on lipid and glucose metabolism, gut microbiota (GM), and serum metabolites. Glucose tolerance, tissue pathology, and serum biochemical levels were conducted to assess the effects of puerarin combined with insoluble dietary fiber (LH) on glucose and lipid metabolism. 16S rRNA sequencing and untargeted metabonomics were employed to explore the underlying mechanisms.

Prevalence, Risk Factors, and Relevant Consequences of Mobile Phone Dependence Among Middle School Students - Guangzhou City, Guangdong Province, China, 2023.

What Is Already Known About This Topic?: The risk factors for mobile phone dependence (MPD) remain inconsistent and debated in the literature. Previous studies in China reported MPD prevalence rates of 26.2% among junior high students and 27.

RELEVANT-C study: patient-reported prevalence of lower extremity lymphedema after sentinel lymph node mapping vs lymphadenectomy after surgery for early-stage cervical cancer.

Objective: To compare the prevalence of patient-reported lower extremity lymphedema and evaluate patient-reported quality of life after sentinel lymph node mapping vs comprehensive lymphadenectomy with or without sentinel lymph node mapping for the surgical management of early-stage cervical cancer.

Methods: In July 2022, we mailed a survey that included a validated 13-item lower extremity lymphedema screening questionnaire to patients who underwent lymph node evaluation at the time of primary surgery for the 2018 International Federation of Gynecology and Obstetrics stage IA1 to IIB cervical cancer between January 1, 2006, and January 31, 2019. We excluded patients diagnosed with lower extremity lymphedema prior to surgery and those who answered ≤6 survey items, and we carried out 2 group comparisons: sentinel lymph node mapping vs lymphadenectomy with or without sentinel lymph node mapping, and patients with lower extremity lymphedema vs patients without.

High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients.

Intraoperative 13C-glucose infusions in patients with NSCLC show that tumors with high labeling of TCA cycle intermediates progress rapidly, resulting in metastasis and early death. Blocking this pathway suppresses metastasis of human NSCLC cells in mice.

Application of Smart Packaging in Fruit and Vegetable Preservation: A Review.

The application of smart packaging technology in fruit and vegetable preservation has shown significant potential with the ongoing advancement of science and technology. Smart packaging leverages advanced sensors, smart materials, and Internet of Things (IoT) technologies to monitor and regulate the storage environment of fruits and vegetables in real time. This approach effectively extends shelf life, enhances food safety, and reduces food waste.

Advanced image-identified extranodal extension of retropharyngeal lymph nodes in the refinement of N classification for nasopharyngeal carcinoma.

Advanced extranodal extension (ENE) in cervical lymph nodes (CLNs) increases the risk of distant metastasis in nasopharyngeal carcinoma (NPC). The 9th NPC staging system classifies N1/N2 patients with advanced CLN ENE as N3 due to similar outcomes. However, the prognostic impact of advanced ENE in retropharyngeal lymph nodes (RLNs) remains unclear.

Analysis of antibacterial drug use and bacterial resistance in psychiatric hospital in the epidemic.

Analyze the use of antibacterial drugs and bacterial resistance in psychiatric hospital during the epidemic. Using the hospital information system and the National Antibacterial Drug Clinical Application Monitoring Network, we retrospectively collected data on the use of antibacterial drugs and bacterial resistance in psychiatric hospitals during the 2022 epidemic. During the 2022 epidemic, our hospital had an antibiotic use rate of 5.

Investigation of the differences in bed microclimate and thermal comfort between school-aged children and adults during sleep onset latency.

The thermal comfort experienced during sleep onset latency (SOL) significantly influences overall sleep quality. While most previous studies have primarily focused on thermal comfort during actual sleep, this study aims to investigate and compare the bed microclimate and thermal comfort during SOL in school-aged children and adults, taking into account their differing physiological characteristics and thermal preferences under various sleep thermal conditions. Fourteen school-aged children and fourteen adults participated in two experiments conducted under winter conditions (8 °C and 11 °C), as well as two experiments under transitional conditions (21 °C and 24 °C).

Antibacterial and metalloproteinase-inhibited zinc-doped bioactive glass nanoparticles for enhancing dentin adhesion.

Objectives: Novel zinc-doped bioactive glass nanoparticles (ZnBGNs) were designed for dental adhesive to enable multifunctional properties for dentin bonding durability.

Methods: ZnBGNs were synthesized via the sol-gel template method and characterized via TEM, SEM and EDS. ZnBGNs were added from 2.

Deciphering the Role of PEGylation on the Lipid Nanoparticle-Mediated mRNA Delivery to the Liver.

Organ- and cell-specific delivery of mRNA via modular lipid nanoparticles (LNPs) is promising in treating various diseases, but targeted cargo delivery is still very challenging. Most previous work focuses on screening ionizable and helper lipids to address the above issues. Here, we report the multifacial role of PEGylated lipids in manipulating LNP-mediated delivery of mRNA to the liver.

Basket study of oral progesterone antagonist onapristone extended-release in combination with anastrozole in progesterone receptor-positive recurrent adult-type granulosa cell tumor of the ovary.

Objective: We sought to determine the safety and efficacy of the oral progesterone antagonist onapristone in combination with anastrozole in patients with recurrent progesterone receptor-positive adult-type granulosa cell tumor of the ovary.

Methods: This was a single-institution phase II study of patients with progesterone receptor-positive adult-type granulosa cell tumor who received at least 1 prior line of chemotherapy. Patients were enrolled from November 2021 to August 2022 and tissue was evaluated for progesterone receptor status via immunohistochemistry.

Application of a semi-active robotic system for implant placement in atrophic posterior maxilla: A retrospective case series.

Objective: The study aimed to evaluate the accuracy and safety of a semi-active robotic system for implant placement in atrophic posterior maxilla.

Methods: Patients underwent robot-assisted implant placement in atrophic posterior maxilla were identified and included. Cone-beam computed tomography (CBCT) was performed before surgery.