Development and validation of a comprehensive predictive model for surgical planning in patients with renal cell carcinoma and inferior vena cava tumor thrombus.

Objective: To investigate preoperative predictors for selecting different surgical approaches in patients with renal cell carcinoma with inferior vena cava (IVC) tumor thrombus (RCC-IVCTT), and to establish and validate corresponding predictive models.

Methods: Clinical data of 583 RCC-IVCTT patients were retrospectively analyzed. Of these, 465 cases were used to construct predictive models, and 118 cases were used for validation.

Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo.

Kinesin spindle protein (KSP) plays a crucial role during mitosis, making it an attractive target for cancer treatment. Herein, we report the design, synthesis, and evaluation of the first series of KSP degraders by using the utilization of the proteolysis-targeting chimera (PROTAC) technology. Compound 21 was identified as a potent KSP degrader with a DC (concentration causing 50 % of protein degradation) value of 114.

Casting New Light on the Retinol and Retinyl Palmitate Functions as Chemical Enhancers for Transdermal/Topical Drug Delivery.

Retinol and retinyl palmitate, with excellent whitening and antioxidant activities, are widely used as essential functional ingredients in transdermal preparations and skincare products. Herein, for the first time, the influence and underlying mechanisms of retinol and retinyl palmitate on the skin penetration of caffeine are investigated. It is found that the penetration of caffeine is very significantly enhanced by retinol and retinyl palmitate with 2.

Depletion of regulatory T cells enhances the T cell response induced by the neoantigen vaccine with weak immunogenicity.

Background: The neoantigen vaccine has remarkable potential in treating advanced cancer due to its tumor specificity and ability to bypass central tolerance mechanisms. However, numerous neoantigens show poor immunogenicity, and the immune inhibitory factors of present in both tumors and tumor-draining lymph nodes impair the efficacy of cancer neoantigen vaccine. Eliminating immunosuppressive cells will improve the priming and expansion of anti-tumor immune cells induced by the vaccine.

Effects of Perillaldehyde and Polyamines on Defense Mechanisms of Sweet Potatoes against .

Sweet potato () serves as a significant food and economic crop worldwide. However, its production and safety are jeopardized by black rot, a disease caused by . Although polyamines (PAs) are common biological growth factors, their function in the storage of fruits and vegetables remains poorly understood.

Kirigami-Inspired Stretchable Piezoelectret Sensor for Analysis and Assessment of Parkinson's Tremor.

Human muscle activity contains rich information that can reflect human movement patterns and conditions of diseases or physical abnormalities. Flexible pressure sensors enable the assessment of muscle tremors in Parkinson's disease (PD) through Force Myography (FMG). Here, an easily fabricated, ultra-sensitive, and stretchable piezoelectret pressure sensor is presented.

Dual-synergistic effect of medium-entropy metal sulfoselenide nanoparticles toward efficient overall seawater splitting.

Developing efficient and durable electrodes for overall water splitting (OWS) in seawater electrolytes is a major challenge. Herein, we synthesized highly active and stable Fe(CoNi)SSe medium-entropy metal sulfoselenide (MESSe) nanoparticles for the electrodes. The Fe(CoNi)SSe MESSe electrode exhibited excellent electrocatalytic performance in alkaline simulated seawater, with a η100 value of 156 mV for the hydrogen evolution reaction and 262 mV for the oxygen evolution reaction.

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly.

Acoustic bioassembly is recently regarded as a highly efficient biofabrication tool to generate functional tissue mimics. Despite their capacity of directly patterning live cells with close intercellular proximity, most acoustic bioassembly techniques are currently limited to generate some specific simple types of periodic and symmetric patterns, which represents an urgent challenge to emulate geometrically complex cytoarchitecture in human tissue. To address this challenge, we herein demonstrate a soft-lithographically defined acoustic bioassembly (SLAB) technique that enables to assemble live cells into geometrically defined arbitrary multicellular structures.

Protoplast transient transformation facilitates subcellular localization and functional analysis of walnut proteins.

Walnut (Juglans regia), an important contributor to oil production among woody plants, encounters research constraints due to difficulties in the subcellular localization and functional analysis of its proteins. These limitations arise from the protracted fruiting cycle and the absence of a reliable transient gene transformation system and organelle markers. In this study, we established a transient expression system using walnut protoplasts and generated fluorescent-tagged organelle markers, whose localization was validated against Arabidopsis (Arabidopsis thaliana) organelle markers.

Top-down architecture of magnetized micro-cilia and conductive micro-domes as fully bionic electronic skin for de-coupled multidimensional tactile perception.

Electronic skin (E-skin) has attracted considerable attention for simulating the human sensory system for use in prosthetics, human-machine interactions, and healthcare monitoring. However, it is still challenging to fully mimic the skin function that can de-couple stimuli such as normal/tangential forces, contact/non-contact behaviors, and react to high-frequency inputs. Herein, we propose fully bionic E-skin (FBE-skin), which consists of a magnetized micro-cilia array (MMCA), a micro-dome array (MDA), and flexible electrodes to completely duplicate the hairy layer, epidermis/dermis interface, and subcutaneous mechanoreceptors of human skin.

Evaluation of the Optimum Dietary Arachidonic Acid Level and Its Essentiality for Black Seabream (): Based on Growth and Lipid Metabolism.

The aim of this study was to investigate how dietary arachidonic acid (ARA) level affects growth performance and lipid metabolism in juvenile black seabream (). A feeding trial was conducted for 8 weeks, during which the fish (0.99 ± 0.

The Interrelation of Blood Urea Nitrogen-to-Albumin Ratio with Three-Month Clinical Outcomes in Acute Ischemic Stroke Cases: A Secondary Analytical Exploration Derived from a Prospective Cohort Study.

Objective: This study targeted elucidating the intricate correlation of the blood urea nitrogen (BUN)-to-albumin (BUN/Alb) ratio with adverse outcomes (AOs) at 3-month in acute ischemic stroke (AIS) cases within a Korean cohort.

Methods: The cohort involved a comprehensive dataset of 1850 AIS cases from a South Korean hospital, spanning from January 2010 to December 2016. To discern the linear relationship of the BUN/Alb ratio with AOs in AIS cases, utilization of a binary logistic regression model (BLRM) was implemented.

Stabilized Carbon Radical-Mediated Assembly of Arylthianthrenium Salts, Alkenes and Amino Acid/Peptide Derivatives.

Efficiently assembling amino acids and peptides with bioactive molecules facilitates the modular and streamlined synthesis of a diverse library of peptide-related compounds. Particularly notable is their application in pharmaceutical development, leveraging site-selective late-stage functionalization. Here, a visible light-induced three-component reaction involving arylthianthrenium salts, amino acid/peptide derivatives, and alkenes are introduced.

Dispersive terahertz metasurface fed by a horn antenna for highly oriented 2D beam steering.

Highly oriented beam steering will enhance power density and field of view (FOV) in terahertz wireless links. Metasurface can be constructed by deliberate arrangement of subwavelength meta-cells to manipulate the wavefront. This paper explores a dispersive metasurface with a specific phase gradient patterned in a 2-inch aperture, allowing for collimated beamforming and two-dimensional (2D) beam steering by a combination of frequency tuning and metasurface rotation.

Design and fabrication of all-solid anti-resonant silicate fibers for Yb ASE suppression in Er/Yb fiber amplifier.

In this paper, we report the design, fabrication, and characterization of a passive silicate-glass-based all-solid anti-resonant fiber (AS-ARF) for ∼1 µm transmission suppression. Simulation results demonstrate that the AS-ARF achieves a first high higher order mode (HOM) suppression ratio of over 25 dB in a 26-63 µm core diameter at 1550 nm. Using the drilling and rod-in-tube technique, an AS-ARF was fabricated with a core diameter of 43 µm, a core NA of 0.

Peptide-Guided Assembly of Silver Nanoparticles for the Diagnosis of HER2-Positive Breast Cancer.

Peptide-engineered nanoparticles have great potential for biomedical research and application. In this work, we have designed and fabricated an electrochemical biosensor based on peptide-guided assembly of silver nanoparticles (AgNPs), in which a peptide is endowed with dual functions to recognize target and guide assembly of AgNPs. As a proof of concept, the performance of this biosensor is validated by quantifying human epidermal growth factor receptor 2 (HER2) protein.

The associations between oxidative balance score and serum Klotho level in the U.S. population aged 40-79 years.

The relationship between the oxidative balance score (OBS) and the serum Klotho level has yet to be defined. We sought to investigate the potential relationship between OBS and the serum Klotho level in the U.S.

Global trends and prospects related to macrophage in chronic kidney disease: a bibliometric analysis.

Background And Aims: Macrophages play a variety of widely concerned roles in the process of chronic kidney disease (CKD). To further understand the research hotspots and development trends regarding the relationship between macrophages and CKD, the role of macrophages in the occurrence and progression of CKD was summarized by bibliometrics in this study.

Material And Methods: We collected the studies relevant the role of macrophages in CKD from the Web of Science Core Collection, which included 1332 relevant studies from Jan 1st, 2004 to Jul 6th, 2023 in WoSCC.

New insights into the role of lipids in aroma formation during black tea processing revealed by integrated lipidomics and volatolomics.

Lipids are important tea aroma precursors. Due to the complexity of black tea processing involving both enzymatic and thermal reactions, the role of lipids in black tea aroma formation remained unclear. Herein, the dynamic changes of lipids and volatiles during black tea processing were simultaneously analyzed by lipidomics and volatolomics using ultra-high-performance liquid chromatography coupled to Q-Exactive Orbitrap mass spectrometry (UHPLC-Q-Exactive) and gas chromatography-tandem mass spectrometry (GC-MS/MS).

Efficacy of acupuncture for lumbar disc herniation: changes in paravertebral muscle and fat infiltration - a multicenter retrospective cohort study.

Objective: This study seeks to elucidate the dynamic alterations in the multifidus, erector spinae, and psoas major muscles, along with their fatty infiltration, in patients diagnosed with lumbar disc herniation treated through acupuncture. Concurrently, the Visual Analogue Scale (VAS) and Japanese Orthopedic Association (JOA) scores are employed to evaluate modifications in lumbar and leg pain and the enhancement in lumbar functionality.

Methods: A retrospective multi-center cohort study enrolled 332 adult LDH patients.