Publications by authors named "Zhou P"
In recent years, the incidence of food allergies in children has been increasing annually, significantly affecting the quality of life for patients and their families. It has long been suspected that childhood allergies might potentially lead to behavioral and psychological issues in adulthood, but the specific connection remains unclear. In this study, we established a model of young mice allergic to milk α-casein, conducted behavioral tests, and employed transcriptomics, immunohistochemistry, Golgi staining, and fecal microbiota transplantation to explore the link between early life allergies and adult psychological problems.
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- The study explored the connection between the neutrophil-to-lymphocyte ratio (NLR) and mortality risks in chronic obstructive pulmonary disease (COPD) patients, aiming to clarify its role as a potential biomarker for systemic inflammation and immune activation.
- Data from the National Health and Nutrition Examination Survey (NHANES) was used to analyze 716 COPD patients over a median follow-up of 111.5 months, determining the impact of higher NLR (≥2.56) on mortality rates.
- Results indicated that patients with higher NLR had more than double the risk of all-cause mortality (HR = 2.07) and cardiovascular mortality (HR = 3.03) compared to those
Background: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Clinically, the therapeutic strategy of PD could only alleviate the symptoms. Nursing plays a crucial role in providing patient education, symptom management, and psychosocial support.
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- Rosacea is a chronic skin condition, and this study reveals that unique cell changes in the skin of affected patients may involve a specific type of keratinocyte damaged by IFNγ signaling.* -
- Research indicates that rosacea is characterized by an increase in various inflammatory cells and dysfunctional vascular cells, which contribute to its symptoms.* -
- Fibroblasts are identified as central players in producing inflammatory signals related to rosacea, and targeting these cells could be a potential strategy for treating the condition.*
Article Synopsis
- A new palladium-catalyzed reaction was developed to efficiently create pyrrolo[1,2-]quinolones from a specific compound involving allenes.
- The process combines two key steps: cyclization and direct arylation, resulting in the formation of multiple new chemical bonds and rings.
- This method is versatile and can work with various substrates and functional groups effectively.
Background: Gastric adenocarcinoma of the fundic gland type (GA-FG) is a newly described variant of gastric adenocarcinoma with lack of knowledges regarding its genetic features.
Methods: We performed whole-genome sequencing (WGS) in formalin-fixed paraffin-embedded (FFPE) tumor tissues and matched adjacent noncancerous specimens from 21 patients with GA-FG, and integrated published datasets from 1105 patients with traditional gastric adenocarcinoma with the purpose of dissecting genetic determinants both common to conventional gastric adenocarcinoma and unique to GA-FG disease.
Results: We characterized the genomic architecture of GA-FG disease, revealing the predominant proportion of C > T substitution among the six types of SNVs.
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- The text indicates that an article has been formally retracted.
- The specific article being retracted is identified by its DOI: 10.1016/j.jsps.2022.08.001.
- This means the findings or claims in this article are no longer considered valid or reliable.
Theoretical advances in understanding and enhancing the thermostability of energetic materials.
Phys Chem Chem Phys
October 2024
Article Synopsis
- Scientists are trying to make safer energetic materials, which are used in things like explosives and rockets, by studying how heat affects them.
- They use complex calculations and computer simulations to understand how these materials behave when they get hot and how to make them more stable.
- Recent technology, like machine learning, helps researchers quickly find new materials that work better and stay safe under high temperatures, like a new material called ICM-104 that shows great promise.
How to reduce the high incidence rate and mortality of colorectal cancer (CRC) effectively is the focus of current research. Endoscopic treatment of early-stage CRC and colorectal adenomas (CAC) has a high success rate, but although several treatments are available for advanced CRC, such as surgery, radiotherapy, chemotherapy, and immunotherapy, the 5-year survival rate remains low. In view of the high incidence rate and mortality of CRC, early rational drug prevention for high-risk groups and exploration of alternative treatment modalities are particularly warranted.
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- * The emerging supramolecular deep eutectic solvents (SUPRADES), particularly CD-based variants, are being explored for their potential to improve extraction efficiency and stability of food components.
- * This review emphasizes the need for further development and practical applications of CD-based SUPRADES in the food industry, while addressing challenges related to formulation and scalability in functional foods.
Article Synopsis
- The study investigates the effects of adding phosphorus slag (PS) to sewage sludge (SS) composting, aiming to understand its impact on greenhouse gas emissions and the process of humification.
- The introduction of PS not only increased temperatures during composting but also led to significant reductions in nitrogen oxide (NO) emissions, by as much as 88.6% with higher concentrations of PS.
- Additionally, the use of PS improved microbial diversity and waste aeration, enhancing beneficial bacteria while reducing harmful species, showcasing PS as a viable and efficient waste treatment option.
Article Synopsis
- Achalasia is a rare disorder affecting the esophagus, linked to immune system issues that aren't fully understood yet.
- The research used Mendelian randomization and genome-wide association studies to find connections between cytokine levels and achalasia, focusing on key cytokines and their effects on the lower esophageal sphincter.
- Findings indicated that specific cytokines (Eotaxin, MIP1b, SeSelectin, TRAIL) are linked to achalasia and could be potential targets for drug development, with particular roles for TNFSF10 monocytes and IL1RN macrophages in the disease's inflammatory processes.*
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- This study investigates how combining intermittent fasting and pulsed radiofrequency energy (PRFE) can enhance healing in diabetic wounds, aiming to develop innovative treatments for diabetes-related injuries.
- Using diabetic mouse models, researchers tested the effects of fasting and PRFE over multiple days, measuring various healing factors such as wound closure rates, cell growth, and blood vessel formation.
- Results showed that the combination therapy significantly improved wound healing compared to individual treatments, effectively promoting cell migration, reducing oxidative stress, and encouraging the growth of nerves and blood vessels.
Comparison of maternal and neonatal outcomes between vaginal birth after cesarean section and normal vaginal birth.
J Matern Fetal Neonatal Med
December 2024
Article Synopsis
- This study compares outcomes of vaginal birth after cesarean (VBAC) and normal vaginal birth (NVB) in a cohort of 1,024 women at a hospital in China from 2019 to 2020.
- The VBAC group had an 87.5% success rate and showed higher rates of complications like uterine rupture and postpartum hemorrhage compared to the NVB group, which had a 100% success rate.
- While VBAC is generally safe, it carries more specific risks, highlighting the need for careful candidate selection and monitoring to improve outcomes.
The composition and physiochemical properties of the solid electrolyte interphase (SEI) significantly impact the electrochemical cyclability of the Li metal. Here, we introduce a trace dual-salt electrolyte additive (TDEA) that accelerates LiF production from FEC decomposition and improves the LiF distribution, resulting in earlier LiF precipitation and the formation of a LiF-rich SEI on the Li anode. TDEA at a millimolar-level concentration was found to alter the morphology of deposited Li, suppress Li dendrite formation, and increase the cycling time and operating current density for Li anodes.
View Article and Find Full Text PDFObjective: To explore the value of dual-accelerated simultaneous multi-slice (SMS) imaging in diffusion tensor imaging (DTI) of glioma.
Methods: Thirty-four patients with glioma who underwent magnetic resonance imaging (MRI) in our hospital from January 2022 to March 2023 were randomly selected. The results of dual-accelerated SMS-DTI and conventional DTI were retrospectively analyzed.
Article Synopsis
- Earthen sites, like the Qin Shi Huang Emperor's Mausoleum, are vital to China's cultural heritage but face deterioration due to environmental changes, creating a need for microbial disease control.
- Researchers analyzed soil samples and microbial communities, discovering diverse pathogenic fungi linked to different environmental conditions within the exhibition hall.
- Allicin gas showed effectiveness in inhibiting the growth of various harmful fungi, suggesting potential strategies for protecting these valuable cultural relics.
Article Synopsis
- Tumor-associated macrophages (TAMs) significantly influence the recurrence and progression of clear cell renal cell carcinoma (ccRCC), but their mechanisms are not fully understood.
- Researchers utilized single-cell transcriptome analysis and algorithms to investigate the diversity of TAMs, discovering a particular subset known as "TAM2" that promotes ccRCC metastasis.
- The transcription factor TCF7L2 was identified as a crucial regulator for TAM2, enhancing its interactions with cancer cells and contributing to aggressive tumor behavior.
D-peptides, the mirror image of canonical L-peptides, offer numerous biological advantages that make them effective therapeutics. This article details how to use DexDesign, the newest OSPREY-based algorithm, for designing these D-peptides . OSPREY physics-based models precisely mimic energy-equivariant reflection operations, enabling the generation of D-peptide scaffolds from L-peptide templates.
View Article and Find Full Text PDFObjective: To explore the link between plasma aldosterone concentration (PAC) and the prevalence of metabolic dysfunction-related fatty liver disease (MAFLD) in hypertensive patients.
Methods: We analyzed data from 41,131 hospitalized patients from January 1, 2014, to December 31, 2023. Multivariate logistic regression models tested associations, with threshold, subgroup, and sensitivity analyses conducted to validate findings.
Article Synopsis
- Bisphenol A (BPA) is known to have harmful effects on human health, leading to its restriction, while Bisphenol AP (BPAP), a potential substitute, lacks thorough health impact studies.
- The current research found that BPAP exposure negatively affects mouse oocyte maturation by causing an arrest in the metaphase I stage of meiosis, inhibiting polar body extrusion, and disrupts normal cell cycle processes.
- BPAP exposure also results in increased DNA damage, affects cytoskeletal assembly and histone modifications, indicating that BPAP is not a safe alternative to BPA for reproductive health.
Article Synopsis
- Scientists created a computer program called a convolutional neural network (CNN) to help understand brain activity from EEG signals while patients are asleep from anesthesia.
- They tested this program on 40 surgery patients, dividing them into two groups to receive different types of anesthesia and then analyzed their brain wave patterns.
- The CNN was really good at telling when the patients were unconscious, doing better than other methods, and showed that certain brain wave measurements were important for monitoring consciousness during surgery.
The ability to form robust biofilms and secrete a diverse array of virulence factors are key pathogenic determinants of , causing a wide range of infectious diseases. Here, we characterized as a VraR-regulated gene encoding a cell wall inhibition-responsive protein (CwrA) using electrophoretic mobility shift assays. We constructed deletion mutants in the genetic background of methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains.
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