Management of oblique root fracture in the middle third of two maxillary immature central incisors with severe caries in mixed dentitions: a case report.

Mid-root fractures are rare injuries in young permanent teeth and tend to have poor prognoses. This study presents a case of oblique root fracture of both maxillary immature central incisors in the middle third accompanied by delayed dental visit and severe caries of all primary teeth. After restoring all the primary and permanent teeth that needed stabilization, the coronal fragments were repositioned and stabilized with a flexible splint consisting of orthodontic wire and composite resin.

Utilization and affordability of health insurance coverage for rare disease drugs in a first-tier city in Northeast China from 2018 to 2021: a study based on the health insurance claims database.

Objective: The accessibility issue of orphan drugs in China is prominent. Based on real-world data from a tier-one city in Northeast China, this study aims to analyze the current usage and affordability of orphan drugs for rare diseases.

Methods: The data was sourced from the health insurance claims data of a certain city from 2018 to 2021, including a total of 16 orphan drugs.

Photoplethysmography-based non-invasive blood pressure monitoring via ensemble model and imbalanced dataset processing.

Photoplethysmography, a widely embraced tool for non-invasive blood pressure (BP) monitoring, has demonstrated potential in BP prediction, especially when machine learning techniques are involved. However, predictions with a singular model often fall short in terms of accuracy. In order to counter this issue, we propose an innovative ensemble model that utilizes Light Gradient Boosting Machine (LightGBM) as the base estimator for predicting systolic and diastolic BP.

Sensitivity-improved SERS detection of SARS-CoV-2 spike protein by Au NPs/COFs integrated with catalytic-hairpin-assembly amplification technology.

Background: The COVID-19 pandemic, caused by the novel coronavirus, has had a profound impact on global health and economies worldwide. This unprecedented crisis has affected individuals, communities, and nations in diverse manners. Developing simple and accurate diagnostic methods is an imperative task for frequent testing to mitigate the spread of the virus.

Cardiotoxicity risk induced by sanitary insecticide Dimefluthrin.

Dimefluthrin (DIM) is a commonly utilized sanitary insecticide, predominantly employed for indoor pest management within residential and public environments directly interacting with human habitation. However, the usage of DIM is escalating with increasing mosquito resistance, prompting concerns about its health risks. Here, using zebrafish as a research model, we systematically evaluated DIM's impact on human health.

A Review on the Video-Based River Discharge Measurement Technique.

The hydrological monitoring of flow data is important for flood prevention and modern river management. However, traditional contact methods are increasingly struggling to meet the requirements of simplicity, accuracy, and continuity. The video-based river discharge measurement is a technique to monitor flow velocity without contacting the water body by using the image-recognition algorithms, which has been verified to have the advantages of full coverage and full automation compared with the traditional contact technique.

Associations between Unsociability and Peer Problems in Chinese Children and Adolescents: A Meta-Analysis.

Research has shown that unsociability, reflected as a personal choice, is not necessarily associated with socio-emotional problems in Western countries. However, the associations between unsociability and peer problems are consistently evident in Chinese culture, yet the strength and direction in these associations are mixed. The present study aimed to examine whether unsociability is associated with peer problems and explored the potential moderators among the associations.

EBV-positive small cell neuroendocrine carcinoma of nasopharynx as a probably unique subtype of neuroendocrine carcinoma: a clinicopathologic study of three cases and literature review.

Background: There is currently scarcity of information on small cell neuroendocrine carcinoma of the nasopharynx (SCNEC-nasopharynx). It is believed that this type of cancer is not associated with Epstein-Barr virus (EBV) infection and is indistinguishable from classic SCNEC occurring in other organs.

Materials And Methods: Herein we provided 3 cases of nasopharyngeal mass in our hospital, two males and one female.

A novel dual-recognition fluorescent biosensor for sialyl-Lewis sensitive detection.

Sialyl-Lewis (SLe) is a tetrasugar, which plays an important role in initial inflammation and cancer cell metastasis, and can be used as a marker for cancer diagnosis and prognosis or a therapeutic target. Detecting SLe from complex biological media remains a significant challenge. Herein, a single-stranded DNA aptamer of SLe was screened based on the double-stranded DNA library-modified magnetic bead (MB)-SELEX technology.

[Regulatory effect of Tingli Dazao Xiefei Decoction on asthmatic rats by urine metabolomics].

Urine metabolomics based on ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry(UHPLC-Q-TOF-MS) was utilized to investigate the metabolic regulation mechanism of Tingli Dazao Xiefei Decoction(TLDZ) in rats with allergic asthma. SD male rats were divided into a normal group, a model group, a dexamethasone group, and a TLDZ group. The allergic asthma model was established by intraperitoneal injection of ovalbumin(OVA) to induce allergy, combined with atomization excitation.

Trafficking circuit of CD8 T cells between the intestine and bone marrow governs antitumour immunity.

Immunotherapy elicits a systemic antitumour immune response in peripheral circulating T cells. However, the T cell trafficking circuit between organs and their contributions to antitumour immunity remain largely unknown. Here we show in multiple mouse leukaemia models that high infiltration of leukaemic cells in bone marrow (BM) stimulates the transition of CD8CD44CD62L central memory T cells into CD8CD44CD62L T cells, designated as inter-organ migratory T cells (T cells).

Process Manufacturing Intelligence Empowered by Industrial Metaverse: A Survey.

The intelligent goal of process manufacturing is to achieve high efficiency and greening of the entire production. Whereas the information system it used is functionally independent, resulting to knowledge gaps between each level. Decision-making still requires lots of knowledge workers making manually.

A comprehensive overview of recent advances in generative models for antibodies.

Therapeutic antibodies are an important class of biopharmaceuticals. With the rapid development of deep learning methods and the increasing amount of antibody data, antibody generative models have made great progress recently. They aim to solve the antibody space searching problems and are widely incorporated into the antibody development process.

Inhalable cardiac targeting peptide modified nanomedicine prevents pressure overload heart failure in male mice.

Heart failure causes considerable morbidity and mortality worldwide. Clinically applied drugs for the treatment of heart failure are still severely limited by poor delivery efficiency to the heart and off-target consumption. Inspired by the high heart delivery efficiency of inhaled drugs, we present an inhalable cardiac-targeting peptide (CTP)-modified calcium phosphate (CaP) nanoparticle for the delivery of TP-10, a selective inhibitor of PDE10A.

Follicular fluid lipidomics analysis reveals altered lipid signatures in patients with polycystic ovary syndrome.

Background: This research investigates the metabolic profiles of follicular fluid (FF) samples from patients with polycystic ovary syndrome (PCOS) undergoing fertilisation and aims to identify diagnostic and therapeutic biomarkers for PCOS through lipidomic analysis.

Methods: We performed non-targeted lipid analysis of FF samples from women with PCOS ( = 6) and normal controls ( = 6) using ultra-high-performance liquid chromatography-tandem mass spectrometry. Differential lipids between the two groups were screened using multidimensional statistical analysis, followed by fold change analysis and -tests to identify potential PCOS biomarkers.

[Clinical efficacy of nusinersen sodium in the treatment of children with spinal muscular atrophy].

Objectives: To investigate the efficacy and safety of nusinersen sodium in the treatment of children with spinal muscular atrophy (SMA).

Methods: A retrospective analysis was conducted on the clinical data of 50 children with 5q SMA who received nusinersen sodium treatment and multidisciplinary treatment management in Shanxi Children's Hospital from February 2022 to February 2024.

Results: Compared with the baseline data, 67% (8/12), 74% (35/47), and 74% (35/47) of the SMA children had a clinically significant improvement in the scores of Philadelphia Infant Test of Neuromuscular Disorders, Hammersmith Functional Motor Scale Expanded, and Revised Upper Limb Module, respectively, and the distance of 6-minute walking test increased from 207.

Children's oppositional defiant disorder symptoms and neural synchrony in mother-child interactions: An fNIRS study.

Interpersonal neural synchrony (INS) between mothers and children responds to the temporal similarity of brain signals in joint behavior between dyadic partners and is considered an important neural indicator of the formation of adaptive social interaction bonds. Parent-child interactions are particularly important for the development and maintenance of oppositional defiant disorder (ODD) in children, but the underlying neurocognitive mechanisms are unknown. Therefore, in the current study we measured INS between mothers and children in interactions by using simultaneous functional Near-infrared Spectroscopy (fNIRS), and explored its association with ODD symptoms in children.

Eveningness is associated with more severe depressive symptoms independently of sleep quality and fatigue level only in first-episode but not recurrent depression in major depressive disorder.

People with an evening chronotype have an increased risk of experiencing a major depressive disorder (MDD). It is unclear if this effect is predominantly related to the initial development of MDD or also present in recurrent episodes. The current study aimed to investigate if the association between chronotype and depressive severity in MDD patients is comparable in MDD patients with first and recurrent episodes.

A noval noninvasive targeted therapy for osteosarcoma: the combination of LIFU and ultrasound-magnetic-mediated SPIO/TP53/PLGA nanobubble.

Purpose: Osteosarcoma (OS) is the most common type of primary malignant bone tumor. Transducing a functional TP53 gene can effectively inhibit OS cell activity. Poly lactic acid-glycolic acid (PLGA) nanobubbles (NBs) mediated by focused ultrasound (US) can introduce exogenous genes into target cells in animal models, but this technique relies on the passive free diffusion of agents across the body.

Higher homocysteine and fibrinogen are associated with early-onset post-stroke depression in patients with acute ischemic stroke.

Background: Post-stroke depression (PSD) is a well-established psychiatric complication following stroke. Nevertheless, the relationship between early-onset PSD and homocysteine (Hcy) or fibrinogen remains uncertain.

Methods: Acute ischemic stroke (AIS) patients who met the established criteria were enrolled in this study.