Advances in sulodexide-based long-term anticoagulation for a myasthenia gravis patient with giant thymoma.

This case report describes a geriatric male patient with myasthenia gravis (MG) secondary to giant thymoma, presenting with progressive muscle weakness and ptosis. The diagnosis of MG was confirmed through pathology, imaging, and laboratory evaluations. Considering the significant surgical risks associated with the giant thymoma, adjuvant chemotherapy was initiated.

The impact of dietary copper intake on cardiovascular morbidity and mortality among hypertensive patients: a longitudinal analysis from NHANES (2001-2018).

While the impact of macronutrients on health is well-understood, the influence of micronutrients such as copper on cardiovascular health remains less explored. Copper, vital for heart function and antioxidant defense, may affect cardiovascular health through its role in enzymatic activities that reduce oxidative stress. This study evaluates the relationship between dietary copper intake and cardiovascular outcomes in hypertensive patients using data from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018.

Perception of distance during self-motion depends on the brain's internal model of the terrain.

The body's geometrical relationship with the terrain is important for depth perception of human and non-human terrestrial animals. Static human observers in the dark employ the brain's internal model of the terrain, the intrinsic bias, to represent the ground as an allocentric reference frame for coding distance. However, it is unknown if the same ground-based coding process operates when observers walk in a cue-impoverished environment with visible ground surface.

Spatial-Temporal Information Fusion for Thyroid Nodule Segmentation in Dynamic Contrast-Enhanced MRI: A Novel Approach.

This study aims to develop a novel segmentation method that utilizes spatio-temporal information for segmenting two-dimensional thyroid nodules on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Leveraging medical morphology knowledge of the thyroid gland, we designed a semi-supervised segmentation model that first segments the thyroid gland, guiding the model to focus exclusively on the thyroid region. This approach reduces the complexity of nodule segmentation by filtering out irrelevant regions and artifacts.

Machine Learning-Based Mortality Prediction for Acute Gastrointestinal Bleeding Patients Admitted to Intensive Care Unit.

Objective: The study aimed to develop machine learning (ML) models to predict the mortality of patients with acute gastrointestinal bleeding (AGIB) in the intensive care unit (ICU) and compared their prognostic performance with that of Acute Physiology and Chronic Health Evaluation II (APACHE-II) score.

Methods: A total of 961 AGIB patients admitted to the ICU of Renmin Hospital of Wuhan University from January 2020 to December 2023 were enrolled. Patients were randomly divided into the training cohort (n = 768) and the validation cohort (n = 193).

Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge-Like Framework and Cell Guidance.

Engineering hollow fibers with precise surface microstructures is challenging; yet, essential for guiding cells alignment and ensuring proper vascular tissue function. Inspired by Euplectella sponges, a novel strategy to engineer biomimetic hollow fibers with spiral surface microstructures is developed. Using oxidized bacterial cellulose, bacterial cellulose, and polydopamine, a "brick-and-mortar" scaffold is created through precise shear control during microfluidic coaxial spinning.

From adhesion to invasion: the multifaceted roles of lipoproteins.

Tuberculosis (TB) is caused by , which poses a significant threat to human health. Lipoproteins are predominantly found in the cell wall during infection of the invading host. The cell wall interacts closely with the host cell in direct contact.

Genomic characteristics and phylogenetic analyses of colonization and infection with carbapenem-resistant in multicenter intensive care units: a cohort study.

Unlabelled: Carbapenem-resistant () poses a major threat to global public health. This study aimed to investigate the genomic characteristics and phylogenetic relatedness of colonization and infection with among intensive care unit (ICU) patients. A total of 61 isolates, including 29 non-ICU-acquired and 32 ICU-acquired strains, were collected by active screening and infection culture from 16 ICUs through a multicenter cohort study.

Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Infections.

Purpose: is a globally prevalent pathogen responsible for severe hospital- and community-acquired infections, and presents significant challenges for clinical management. Current therapeutic strategies are no longer able to meet the clinical needs; therefore, there is an urgent need to develop novel therapeutic strategies. This study aimed to evaluate the efficacy of phage therapy in treating bacterial infections.

An Immunocompetent 56-Year-Old Woman With Multiple Enlarged Lymph Nodes and Recurrent Fevers.

A 56-year-old woman was admitted to our hospital, presenting with a history of recurrent fevers persisting for over 2 months. The febrile episode was self-limiting, accompanied by cough without significant expectoration, with the fever predominantly manifesting during the afternoon and evening hours. Furthermore, there were no concurrent symptoms indicative of chest tightness, wheezing, dyspnea, or hemoptysis.

Poor Glycemic Control in Carbapenem-Resistant Infections: Impact on Epidemiological Features, Mortality Risks, and Polymyxin Resistance.

Purpose: This study aims to investigate the relationship between glycemic control and epidemiological characteristics of patients infected with carbapenem-resistant (CRKP), to identify mortality risk factors associated with CRKP infection, and to evaluate the impact of glucose on the resistance of CRKP to polymyxin and serum killing.

Patients And Methods: Clinical cases of 218 patients infected with CRKP were collected from a large tertiary public hospital in Anhui Province. We analyzed whether the glycemic control impacts the clinical and laboratory manifestations of infected patients.

Metabolic Profiles of Pregnancy with Polycystic Ovary Syndrome: Insights into Maternal-Fetal Metabolic Communication.

Context: PCOS pregnancies are linked to metabolic disorders affecting maternal and fetal outcomes, with maternal metabolites differing from those in normal pregnancies.

Objective: To investigate the metabolic communication at the maternal-fetal interface in PCOS pregnancies.

Design: Placenta and umbilical cord serum were analyzed using gas chromatography-mass spectrometry.

MacNet: a mobile attention classification network combining convolutional neural network and transformer for the differentiation of cervical cancer.

Background: Cervical cancer remains a critical global health issue, responsible for over 600,000 new cases and 300,000 deaths annually. Pathological imaging of cervical cancer is a crucial diagnostic tool. However, distinguishing specific areas of cellular differentiation remains challenging because of the lack of clear boundaries between cells at various stages of differentiation.

All-perovskite tandem solar cells achieving >29% efficiency with improved (100) orientation in wide-bandgap perovskites.

Monolithic all-perovskite tandem solar cells present a promising approach for exceeding the efficiency limit of single-junction solar cells. However, the substantial open-circuit voltage loss in the wide-bandgap perovskite subcell hinders further improvements in power-conversion efficiency. Here we develop wide-bandgap perovskite films with improved (100) crystal orientation that suppress non-radiative recombination.

Insulin resistance as a mediator in the association between nickel exposure and metabolic dysfunction-associated steatotic liver disease.

Background: The myriad implications of heavy metal pollution on human health have garnered substantial attention within the academic domain. Nevertheless, a notable research gap persists, as there is currently insufficient direct investigation elucidating the intricate interplay between nickel exposure and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: The data utilized in this study was sourced from the National Health and Nutrition Examination Survey 2017-2020.

Genome-Wide Identification, Expression and Interaction Analysis of Gene Family in Soybean.

As a globally significant economic crop, the seed size of soybean ( [L.] Merr.) is jointly regulated by internal genetic factors and external environmental signals.

A multi-scale circuit model bridges molecular modeling and experimental measurements of conductive metal-organic framework supercapacitors.

A multi-scale model is crucial for combining experiments and simulations to reveal the energy storage mechanism. As novel electrode materials, conductive metal-organic frameworks (c-MOFs) provide an ideal platform for understanding the energy storage process in supercapacitors. However, the prevailing circuit models lack consideration of the distinctive transmission path of c-MOFs, which hinders accurate descriptions of c-MOF supercapacitors.

Parameter map guided explainable segmentation framework for breast cancer using amide proton transfer weighted imaging.

Background: Amide proton transfer weighted (APTw) imaging has demonstrated extensive clinical applications in diagnosing, treating evaluating, and prognosis prediction of breast cancer. There is a pressing need to automatically segment breast lesions on APTw original images to facilitate downstream quantification, which is however challenging.

Purpose: To build a segmentation model on the original images of APTw imaging sequence by leveraging the varying contrasts between breast lesions and their surrounding glandular and fat tissues displayed on the original images of APTw imaging at different frequency offsets.

Ultrafast Self-Gelling, Adhesive, Anti-Bacterial Coacervate-Based Powders for Enhanced Hemostasis and Wound Healing.

Uncontrolled hemorrhage, especially in non-compressible and deep wounds, remains a critical issue in emergency and surgical care. Existing hemostatic powders often lack rapid gelation, mechanical robustness, and adequate adherence, increasing the risk of rebleeding under high-pressure blood flow. To address these limitations, PQPP, a novel self-gelling hemostatic material composed of polyacrylamide/quaternized chitosan coacervates and polydopamine nanoparticles is developed.

Inhibition of Sat1 alleviates myocardial ischemia-reperfusion injury through regulation of ferroptosis via MAPK/ERK pathway.

Introduction: Myocardial ischemia-reperfusion injury (MIRI) is a prevalent complication in patients with myocardial infarction. The pathological mechanism of MIRI remains elusive. Ferroptosis plays a critical role in MIRI.

Ixekizumab: an alternative for HIV-positive psoriasis patients.

Psoriasis is a recurrent and protracted inflammatory disease. Generalized erythema, plaques, and silvery scales on the surface mainly characterize its skin lesions. Biologics bring new hope to psoriasis patients.

Radiomic features add incremental benefit to conventional radiological feature-based differential diagnosis of lung nodules.

Purpose: To investigate the incremental benefit of adding radiomic features to conventional semantic radiological feature-based differential diagnosis between benign and malignant lung nodules.

Methods: From May 2017 to March 2021, 393 patients with 465 pathologically confirmed lung nodules were enrolled with 54 patients with 54 lung nodules as external testing. Based on manually segmented lung nodules, 1409 radiomics features were extracted.

Association between preoperative D-dimer with morphologic features and surgical outcomes of acute type A aortic dissection.

Objectives: The association between preoperative D-dimer with morphologic features and surgical outcomes of acute type A aortic dissection is still unclear.

Methods: 430 acute type A aortic dissection patients who underwent total arch replacement and frozen elephant trunk in Beijing Anzhen Hospital of Capital Medical University between January 2016 and December 2020 were enrolled in the present study. Patients were divided into higher D-dimer (>2307 ng/ml) group and lower D-dimer (≤2307 ng/ml) group.

All-Aqueous Embedded 3D Printing for Freeform Fabrication of Biomimetic 3D Constructs.

All-aqueous embedded 3D printing, which involves extruding inks in an aqueous bath, has emerged as a transformative platform for the freeform fabrication of 3D constructs with precise control. The use of a supporting bath not only enables the printing of arbitrarily designed 3D constructs but also broadens ink selection for various soft matters, advancing the wide application of this technology. This review focuses on recent progress in the freeform preparation of 3D constructs using all-aqueous embedded 3D printing.

Alzheimer's Disease-Derived Outer Membrane Vesicles Exacerbate Cognitive Dysfunction, Modulate the Gut Microbiome, and Increase Neuroinflammation and Amyloid-β Production.

Although our understanding of the molecular biology of Alzheimer's disease (AD) continues to improve, the etiology of the disease, particularly the involvement of gut microbiota disturbances, remains a challenge. Outer membrane vesicles (OMVs) play a key role in central nervous system diseases, but the impact of OMVs on AD progression remains unclear. In this study, we hypothesized that AD-derived OMVs (OMVs) were a risk factor in AD pathology.