Lymph node metastatic patterns of gastric carcinoma with a combination of adenocarcinoma and neuroendocrine carcinoma components.

Background: Gastric mixed-adenoneuroendocrine carcinoma (G-MANEC) is a subtype of gastric cancer. Building upon prior research findings, we propose that tumours containing both neuroendocrine carcinoma (NEC) and adenocarcinoma (AC) components, with each component ranging from 1% to 99% of the tumour, be classified as a distinct entity. We hereby term this adenoneuroendocrine mixed gastric cancer (G-ANEC).

Reproductive traits of floating Ulva prolifera sporophytes and gametophytes and their contribution to the Yellow Sea green tide.

Since 2007, the Yellow Sea green tide has become a recurring ecological phenomenon with a profound impact on coastal landscapes and marine ecosystems. Floating Ulva prolifera, the primary species driving the Yellow Sea green tide, exhibits morphologically indistinguishable sporophyte and gametophyte stages. This study is the first to systematically explore the growth and reproductive characteristics of U.

Integrating transcriptomic data with a novel drug efficacy prediction model for TCM active compound discovery.

Identifying the active natural compounds remains a challenge for drug discovery, and new algorithms need to be developed to predict active ingredients from complex natural products. Here, we proposed Meta-DEP, a Meta-paths-based Drug Efficacy Prediction based on drug-protein-disease heterogeneity network, where Meta-paths contain all the shortest paths between drug targets and disease-related proteins in the network and drug efficacy is measured by a predictive score according to drug disease network proximity. Experiments show that Meta-DEP performs better than traditional network topology analysis on drug-disease interaction prediction task.

Multifunctional nanoparticles and collagenase dual loaded thermosensitive hydrogel system for enhanced tumor-penetration, reversed immune suppression and photodynamic-immunotherapy.

Breast cancer is the most prevalent and lethal malignancy among females, with a critical need for safer and less invasive treatments. Photodynamic therapy (PDT) can effectively eliminate tumor cells with minimal side effects. Furthermore, the combination of PDT and immunotherapy using nanoparticles has shown promise in treating both primary and distant metastatic tumor cells.

Exploring technical improvements for environmental nucleic acids-based biodiversity assessment and management in coastal ecosystems.

Assessing and conserving marine biodiversity remain critical global challenges, particularly in highly disturbed coastal regions. The use of environmental DNA (eDNA)-metabarcoding has revolutionized biodiversity assessment and management; however, the prevalence of both false positives and negatives continues to be a significant concern. To address these technical errors, we tested two potential methodological improvements in the highly disturbed Guangdong-Hong Kong-Macao Greater Bay Area: (1) the use of random whole-genome amplification (WGA) to reduce false negatives derived from low eDNA concentration, and (2) the application of environmental RNA (eRNA)-metabarcoding to mitigate false positives arising from eDNA contamination by human activities.

Selective Photocatalytic Aerobic Oxidation of Methane to Methyl Hydroperoxide by ZnO-Loaded Single-Atomic Ruthenium Oxide Catalyst.

Photooxidation of CH to value-added chemicals with high selectivity offers a promising pathway to drive the rational utilization of natural gas resources with renewable energy under mild conditions. However, owing to the poor chemoselectivity of reactive oxygen radical formation and consecutive side reactions of primary products, the synthesis of peroxide directly from CH oxidation remains challenging. Here, we report single-atom ruthenium oxide-doped ZnO as a highly selective photocatalyst for the aerobic oxidation of CH to CHOOH.

SPDC-HG: An accelerator of genomic hybrid breeding in maize.

Integrating multiple modern breeding techniques in maize has always been challenging. This study aimed to address this issue by applying a flexible sparse partial diallel cross design composed of 945 maize hybrids derived from 266 inbred lines across different heterotic groups. The research integrated genome-wide association studies, genomic selection and genomic evaluation of parental inbred lines to accelerate the breeding process for developing single-cross hybrids.

Leaf nitrogen allocation to non-photosynthetic apparatus reduces mesophyll conductance under combined drought-salt stress in .

Leaf nitrogen allocation plays a crucial role in determining both photosynthetic function and structural development of plants. However, the effects of drought, salt stress, and their combination on leaf nitrogen allocation, and how these affect mesophyll conductance ( ) and photosynthesis, remain poorly understood. In this study, we first investigated variations in photosynthetic characteristics and leaf nitrogen allocation, and analyzed the relationship between and leaf nitrogen allocation ratios in under drought, salt and combined drought-salt stress.

Identification of quantitative trait loci for yield traits and fine-mapping of using the chromosome segment substitution line-Z708 and dissected single-segment substitution lines.

Identifying quantitative trait loci (QTL) for yield traits using single-segment substitution lines (SSSL) is essential for both targeted breeding and functional analysis of key genes. Here, a wide-grain rice chromosome segment substitution line (CSSL), Z708, carrying four substitution segments from Jinhui35 in the genetic background of Xihui18, was used to identify the QTL associated with grain size. Seven QTL for yield-related traits (, , , , , , and ) were identified on the substitution segments of the fourth and fifth chromosomes of Z708.

Leptin Enhances M1 Macrophage Polarization and Impairs Tendon-Bone Healing in Rotator Cuff Repair: A Rat Model.

Background: Rotator cuff tears are common, affecting more than 60% of individuals older than 80 years, and they have been implicated in 70% of patients with shoulder pain. M1 polarization-related inflammation has been reported to be associated with poor healing outcomes of rotator cuff injury, and leptin, an adipokine, has been reported to be a potential activator of inflammation. However, whether leptin affects rotator cuff repair remains unknown.

Carbon dots as new antioxidants: Synthesis, activity, mechanism and application in the food industry.

Antioxidants not only prevent food spoilage, but also maintain the nutritional value of food, thereby exerting a crucial protective effect on food industry. Nanomaterials have recently been used as antioxidants because of their remarkable potential to scavenge free radicals. Of them, owing to their relatively high biocompatibility and unique physicochemical properties, carbon dots (CDs) have garnered considerable attention.

YGL9 mediates LHC assembly by regulating LHCPs transport and chlorophyll synthesis in rice.

LHC assembly is a fundamental process in forming a peripheral antenna system, which has a significant impact on photosynthesis. However, the molecular mechanism of the LHC assembly still needs to be further investigated in monocotyledonous plants. Here, we identified a bifunctional protein YGL9 in rice, a homolog of cpSRP43 in Arabidopsis, mediates LHC assembly by simultaneously regulating LHCPs transport and chlorophyll synthesis.

Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida.

The aging process is universal, and it is characterized by a progressive deterioration and decrease in physiological function leading to decline on the organismal level. Nevertheless, a number of genetic and non-genetic interventions have been described, which successfully extend healthspan and lifespan in different species. Furthermore, a number of clinical trials have been evaluating the feasibility of different interventions to promote human health.

Early colonization of the deep-sea bottom-The protracted build-up of an ecosystem.

Our understanding of the patterns and processes behind the evolution of deep-marine ecosystems is limited because the body-fossil record of the deep sea is poor. However, that gap in knowledge may be filled as deposits are host to diverse and abundant trace fossils that record the activities of benthic deep-marine organisms. Here, we built a global dataset of trace-fossil occurrences from a comprehensive survey of 720 Ediacaran-Devonian units and show that the establishment of a modern-style deep-marine benthic ecosystem was protracted and coincident with global cooling and increase in oxygenation during the Ordovician.

Mechanism exploration of Wenshen Jianpi Decoction on renoprotection in diabetic nephropathy via transcriptomics and metabolomics.

Background: Diabetic nephropathy (DN) is a severe chronic microvascular complications of diabetes mellitus and the leading cause of end-stage renal disease. Although many therapeutic approaches have been developed for treatment of DN, there is still a risk of disease progression. Wenshen Jianpi Decoction (WSJPD), a traditional Chinese medicine, have demonstrated considerable clinical efficacy in treating DN.

AURKB affects the proliferation of clear cell renal cell carcinoma by regulating fatty acid metabolism.

Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer with a high metastatic rate and high mortality rate. The molecular mechanism of ccRCC development, however, needs further study. Aurora kinase B (AURKB) functions as an important oncogene in various tumors; therefore, in the present study, we aimed to explore the mechanism by which AURKB affects ccRCC development.

Exploration of metastasis-related signatures in osteosarcoma based on tumor microenvironment by integrated bioinformatic analysis.

Background: The present study aims to explore the metastasis-related signatures in connection with tumor microenvironment (TME), revealing new molecular targets promising in improving osteosarcoma (OS) patients' outcomes.

Methods: The high-throughput sequencing data was downloaded from the TARGET database and performed the ESTIMATE algorithm. Metastasis-related information was obtained from the GSE21257 dataset.

W-Mediated Electron Accumulation in Ru-O-W Motifs Enables Ultra-Stable Oxygen Evolution Reaction in Acid.

The development of efficient and durable oxygen evolution reaction (OER) catalysts is crucial for advancing proton exchange membrane water electrolysis (PEMWE) technology, especially in the pursuit of non-iridium alternatives. Herein, we report a Zn, W co-doped RuZnWO (RZW) ternary oxide catalyst that exhibits a low overpotential of 200 mV and remarkable stability for over 4000 hours at 10 mA cm in 0.1 M HClO.

Transcriptome Analysis Reveals the Key Genes and Pathways for Growth, Ion Transport, and Oxidative Stress in Post-Larval Black Tiger Shrimp (Penaeus monodon) Under Acute Low Salt Stress.

As an abiotic stress factor, salinity significantly affects the physiological activities of crustaceans. In this study, transcriptome sequencing was used to evaluate the mechanism of ion transport and the physiological response of black tiger shrimp (Penaeus monodon) under low salt stress. Four hundred post larval (PL) stage P.

The efficacy of core decompression combined with regenerative therapy in early femoral head necrosis: a systematic review and meta-analysis involving 954 subjects.

Background: The debate continues on whether combining core decompression (CD) with regenerative therapy provides a more effective treatment for early femoral head necrosis than CD alone. This systematic review and meta-analysis endeavored to assess its efficacy.

Methods: We systematically searched PubMed, Web of Science, and Cochrane Library through July 2024 for RCTs and cohort studies evaluating the impact of core decompression (CD) with regenerative therapy versus CD alone in early-stage osteonecrosis (ARCO I, II or IIIa or Ficat I or II) of the femoral head (ONFH).

Causal Relationship Between Emotional Disorders and Thyroid Disorders: A Bidirectional Two-Sample Mendelian Randomization Study.

Introduction: The interplay between emotional disorders and thyroid disorders has been subject to numerous observational studies, which have consistently reported associations but have failed to establish clear causal links due to the multifactorial etiology and influences. We conducted a bidirectional two-sample Mendelian randomization (MR) analysis to explore the genetic causal association between emotional disorders and thyroid disorders.

Methods: We employed several methods, including inverse-variance weighted (IVW), weighted median, weighted mode, and MR Egger regression.

Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer.

Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) have garnered significant attention in cancer research because of their potential for precise spatiotemporal drug release tailored to high ROS levels within tumors. Despite the challenges posed by ROS distribution heterogeneity and endogenous supply constraints, this review highlights the strategic alliance of ROS-responsive DDSs with photodynamic therapy (PDT), enabling selective drug delivery and leveraging PDT-induced ROS for enhanced therapeutic efficacy. This review delves into the biological importance of ROS in cancer progression and treatment.

Implementing Trust in Non-Small Cell Lung Cancer Diagnosis with a Conformalized Uncertainty-Aware AI Framework in Whole-Slide Images.

Ensuring trustworthiness is fundamental to the development of artificial intelligence (AI) that is considered societally responsible, particularly in cancer diagnostics, where a misdiagnosis can have dire consequences. Current digital pathology AI models lack systematic solutions to address trustworthiness concerns arising from model limitations and data discrepancies between model deployment and development environments. To address this issue, we developed TRUECAM, a framework designed to ensure both data and model trustworthiness in non-small cell lung cancer subtyping with whole-slide images.

Elucidating the Underlying Allelopathy Effects of on Using Metabolomics Profiling.

dominates the subalpine meadows in Shangri-La (Southwest China) owing to its potent allelopathic effects. However, the effects underlying its allelopathy require further characterization at the physiological and molecular levels. In this study, the physiological, biochemical, and metabolic mechanisms underlying allelopathy were investigated using as a receptor plant.

Sirt1 overexpression inhibits chondrocyte ferroptosis via Ftl deacetylation to suppress the development of osteoarthritis.

Introduction: Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by an imbalance in chondrocyte metabolism. Ferroptosis has been implicated in the pathogenesis of OA. The role of Sirt1, a deacetylase, in mediating deacetylation during ferroptosis in OA chondrocytes remains underexplored.