A body shape index for visceral fat and its changes predict cardiovascular outcomes of heart failure with preserved ejection fraction.

Aims: This study aimed to investigate the relationship between visceral adipose tissue (VAT), measured using a body shape index (ABSI), and outcomes in patients with heart failure with preserved ejection fraction (HFpEF).

Methods: ABSI data and cardiovascular outcomes were obtained from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial. ABSI was calculated using waist circumference (WC), body mass index, and height.

Clarify Confused Nodes via Separated Learning.

Graph neural networks (GNNs) have achieved remarkable advances in graph-oriented tasks. However, real-world graphs invariably contain a certain proportion of heterophilous nodes, challenging the homophily assumption of traditional GNNs and hindering their performance. Most existing studies continue to design generic models with shared weights between heterophilous and homophilous nodes.

A new species of the rib-degenerated loach, genus (Cypriniformes, Cobitidae), from Guangxi, China.

A new species of the genus is described based on morphological comparisons and molecular analyses from specimens of a subterranean tributary of the Hongshui River, Lingyun County, Baise City, and a cave in Jinya Township, Fengshan County, Hechi City, Guangxi, China. Both morphological and molecular data support the validity of The new species can be distinguished from congeners by the following combination of characteristics: whole body except for head and area between pectoral-fin and pelvic-fin origin sparsely covered with minute scales; barbels elongate; five or six branched pectoral-fin rays and four branched pelvic-fin rays; vertebrae 4+42. Maximum-likelihood and Bayesian-inference phylogenetic trees exhibited congruent topological structures, exhibiting high node support for the monophyly of (BPP = 1; BS = 100), which was clustered with the other congeners.

The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors.

Background: Primary central nervous system germ cell tumors (CNS GCTs) are rare intracranial malignancies, and their tumor microenvironment plays a crucial role in tumor initiation and progression. However, the specific characteristics of the immune microenvironment and their clinical significance remain poorly understood.

Methods: This study included 93 paraffin-embedded tissue samples from 90 patients diagnosed with CNS GCTs.

Lesion segmentation method for multiple types of liver cancer based on balanced dice loss.

Background: Obtaining accurate segmentation regions for liver cancer is of paramount importance for the clinical diagnosis and treatment of the disease. In recent years, a large number of variants of deep learning based liver cancer segmentation methods have been proposed to assist radiologists. Due to the differences in characteristics between different types of liver tumors and data imbalance, it is difficult to train a deep model that can achieve accurate segmentation for multiple types of liver cancer.

Single-Cell and Bulk Transcriptomics Reveal the Immunosenescence Signature for Prognosis and Immunotherapy in Lung Cancer.

Background: Immunosenescence is the aging of the immune system, which is closely related to the development and prognosis of lung cancer. Targeting immunosenescence is considered a promising therapeutic approach.

Methods: We defined an immunosenescence gene set (ISGS) and examined it across 33 TCGA tumor types and 29 GTEx normal tissues.

Development and application of a predictive model for survival and drug therapy based on COVID-19-related lncRNAs in non-small cell lung cancer.

Numerous studies have substantiated the pivotal role of long non-coding RNAs (lncRNAs) in the progression of non-small cell lung cancer (NSCLC) and the prognosis of afflicted patients. Notably, individuals with NSCLC may exhibit heightened vulnerability to the novel coronavirus disease (COVID-19), resulting in a more unfavorable prognosis subsequent to infection. Nevertheless, the impact of COVID-19-related lncRNAs on NSCLC remains unexplored.

PolyCL: contrastive learning for polymer representation learning explicit and implicit augmentations.

Polymers play a crucial role in a wide array of applications due to their diverse and tunable properties. Establishing the relationship between polymer representations and their properties is crucial to the computational design and screening of potential polymers machine learning. The quality of the representation significantly influences the effectiveness of these computational methods.

Targeted Delivery and ROS-Responsive Release of Lutein Nanoassemblies Inhibit Myocardial Ischemia-Reperfusion Injury by Improving Mitochondrial Function.

Purpose: Myocardial ischemia-reperfusion injury (MI/RI) is associated with increased oxidative damage and mitochondrial dysfunction, resulting in an elevated risk of mortality. MI/RI may be alleviated by protecting cardiomyocytes from oxidative stress. Lutein, which belongs to a class of carotenoids, has proven to be effective in cardiovascular disease treatment due to its remarkable antioxidant properties, but its application is limited due to its poor stability and low bioavailability in vivo.

The Bony Density of the Pedicle Plays a More Significant Role in the Screw Anchorage Ability Than Other Regions of the Screw Trajectory.

Objective: Osteoporosis is a crucial risk factor for screw loosening. Our studies indicate that the bone mineral density (BMD) in the screw trajectory is a better predictor of screw loosening than the BMD of the lumbar spine or the screw insertion position. Research has shown that anchorage on the screw tip is the most significant factor for screw anchorage ability, while others argue that decreased bony quality in the pedicle poses a significant risk for screw loosening.

Two new hypogean species of the genus (Osteichthyes, Cypriniformes, Nemacheilidae) from Guizhou Province, Southwest China, with underestimated diversity.

Two new species of the genus from southwestern Guizhou Province, China, are described. These are Wu, Luo, Xiao & Zhou, and Lan, Liu, Zhou & Zhou, from Maoying Town, Ziyun County, Guizhou Province, China. Wu, Luo, Xiao & Zhou, is distinguished from other hypogean species of the genus by having a combination of the following characteristics: body naked, scaleless, pigmented markings on surface of body, except ventral; eyes reduced, diameter 2.

 (Cypriniformes, Cyprinidae), a new cave fish with extremely small population size from western Guizhou, China.

This study describes a new species, ., discovered within a cave located in Hongguo Town, Panzhou City, Guizhou Province, southwestern China, with the type locality in the Nanpanjiang River basin. Phylogenetic trees reconstructed based on mitochondrial genes show that the new species represents an independent evolutionary lineage with large genetic differences, 1.

A new species of (Teleostei, Cypriniformes, Xenocyprididae) from Southeast China.

is described from the Qiantang and Oujiang rivers in Zhejiang Province and a tributary of the Yangtze River adjacent to the Qiantang River. It is distinguished from congeners by the following combination of morphological features: no obvious anterior notch on the tip of the upper lip; 45-52 lateral-line scales; 18-21 pre-dorsal scales; two rows of pharyngeal teeth; a maxillary extending to or slightly beyond the vertical anterior margin of the orbit in adult males; a pectoral fin extending to the pelvic fin in adult males; nuptial tubercles on the cheeks and lower jaw of males, which are usually united basally to form a plate; uniform narrow pale pink cross-bars on trunk and two widening significantly on caudal peduncle. Its validity was also supported by its distinct Cyt gene sequence divergence from all congeners and its monophyly recovered in a Cyt gene-based phylogenetic analysis.

AVM: A Manually Curated Database of Aerosol-transmitted Virus Mutations, Human Diseases, and Drugs.

Aerosol-transmitted viruses possess strong infectivity and can spread over long distances, earning the difficult-to-control title. They cause various human diseases and pose serious threats to human health. Mutations can increase the transmissibility and virulence of the strains, reducing the protection provided by vaccines and weakening the efficacy of antiviral drugs.

Patterns of Poly-Victimization Among Early Adolescents: A Latent Class and Two-Wave Latent Transition Analysis.

Background: Poly-victimization involves more than just counting incidents; it varies in severity and type among adolescents and can change over time.

Objective: The aim is to identify latent classes of poly-victimization among children in early adolescence, investigate transition probabilities between these latent categories, and examine the influencing factors.

Methods: We used stratified cluster random sampling to select 2275 junior high students from five rural middle schools in Shantou and Jieyang, China, and surveyed them in two waves.

Association of child maltreatment and school bullying among Chinese adolescents: the mediating role of peer relationships.

Background: School bullying, a serious problem for the physical and mental health of adolescents, is presently a significant issue in China. It is essential to recognize and comprehend potential risk factors and establish efficient preventive strategies. The purpose of this study was to examine the association between childhood maltreatment and school bullying in adolescents and to assess the mediating role of peer relationships.

An intervention study of poly-victimization among rural left-behind children based on the theoretical framework of planned behavior.

Background: Poly-victimization (PV) not only threatens physical and mental health but also causes a range of social problems. Left-behind children in rural areas are more likely to experience PV problems. However, there have been fewer studies on PV among rural children, and even fewer intervention studies.

CD9 and Aryl Hydrocarbon Receptor Are Markers of Human CD19+CD14+ Atypical B Cells and Are Dysregulated in Systemic Lupus Erythematous Disease.

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor whose expression regulates immune cell differentiation. Single-cell transcriptomic profiling was used to ascertain the heterogeneity of AHR expression in human B cell subpopulations. We identified a unique population of B cells marked by expression of AHR, CD9, and myeloid genes such as CD14 and CXCL8.

First description of the female and morphological variations with range extension of (Anura, Rhacophoridae).

Background: Yu, Wang, Hou, Rao and Yang, 2017 was originally described, based on 14 adult male specimens from Lengquan Village, Mengzi, Yunnan, China. So far, this species is known only from south-eastern Yunnan and information on females of this species is not available. During the field surveys in 2023, two specimens (one female and one male) were collected from central eastern Yunnan (Shilin, Kunming, Yunnan, China).

PathMLP: Smooth path towards high-order homophily.

Real-world graphs exhibit increasing heterophily, where nodes no longer tend to be connected to nodes with the same label, challenging the homophily assumption of classical graph neural networks (GNNs) and impeding their performance. Intriguingly, from the observation of heterophilous data, we notice that certain high-order information exhibits higher homophily, which motivates us to involve high-order information in node representation learning. However, common practices in GNNs to acquire high-order information mainly through increasing model depth and altering message-passing mechanisms, which, albeit effective to a certain extent, suffer from three shortcomings: (1) over-smoothing due to excessive model depth and propagation times; (2) high-order information is not fully utilized; (3) low computational efficiency.

Identification of crosstalk genes and immune characteristics between Alzheimer's disease and atherosclerosis.

Background: Advancements in modern medicine have extended human lifespan, but they have also led to an increase in age-related diseases such as Alzheimer's disease (AD) and atherosclerosis (AS). Growing research evidence indicates a close connection between these two conditions.

Methods: We downloaded four gene expression datasets related to AD and AS from the Gene Expression Omnibus (GEO) database (GSE33000, GSE100927, GSE44770, and GSE43292) and performed differential gene expression (DEGs) analysis using the R package "limma".

Shadow prices of agrochemicals in the Chinese farming sector: A convex expectile regression approach.

The use of agrochemical inputs has significantly enhanced agricultural yields in China; however, their excessive utilization has also caused a range of environmental issues. This paper examines the costs associated with reducing agrochemicals by employing shadow prices, which represent the value of the marginal product of agrochemicals, to further develop cost-effective environmental policy measures for reducing their usage. To this end, the shadow prices of agrochemicals have been assessed by adopting a newly developed convex expectile regression approach and using statistical data from 31 provinces in China spanning from 2005 to 2020.

Association between Body Mass Index and Externalizing and Internalizing Symptoms among Chinese Adolescents: Mediating Role of Traditional Bullying and Cyberbullying Victimization.

Background: Externalizing problems, internalizing problems, and obesity are among the greatest challenges to adolescent health. However, the moderating and mediating mechanisms that underlie this association remain predominantly unexplored.

Objectives: In this study, we examined the association between body mass index (BMI) and externalizing and internalizing scores in adolescents, tested whether traditional bullying and cyberbullying mediated the association, and explored the moderated role of sex.

Chromosome-scale genome assemblies of sexually dimorphic male and female Acrossocheilus fasciatus.

Acrossocheilus fasciatus is a stream-dwelling fish species of the Barbinae subfamily. It is valued for its colorfully striped appearance and delicious meat. This species is also characterized by apparent sexual dimorphism and toxic ovum.