Autophagy-Targeted Therapy for Pulmonary Inflammation by 2D MX (M = W, Nb; X = S, Se) Nanosheets.

For biomedical applications, two-dimensional transition metal dichalcogenides (2D TMDCs) are often combined with other elements or functionalized with specific surface ligands, while their intrinsic biological activities are not yet fully understood. This study investigates the anti-inflammatory potential of four unmodified 2D TMDCs, including WS, WSe, NbS, and NbSe nanosheets, in LPS-activated MH-S cells in vitro and in a mouse model of pulmonary inflammation in vivo. Despite their varying compositions, these 2D TMDCs exhibited comparable anti-inflammatory effects in LPS-activated MH-S cells.

Enriched rehabilitation on brain functional connectivity in patients with post-stroke cognitive impairment.

Objective: This study aims to observe the effect of enrichment rehabilitation (ER) on cognitive function in post-stroke patients and to clarify its underlying mechanism.

Methods: Forty patients with post-stroke cognitive impairment (PSCI) meeting the inclusion criteria were randomly assigned to two groups: conventional medical rehabilitation (CM group) and ER intervention (ER group). All patients underwent assessments of overall cognitive function, attention function, and executive function within 24 h before the start of training and within 24 h after the 8 weeks of training.

Interface Microstructure and Properties of 42CrMo/Cr5 Vacuum Billet Forged Composite Roll.

Composite roll produced through casting methods typically remain in the as-cast state after forming. During the preparation process, extended exposure to high temperatures often results in microstructural coarsening at the interface and surface layers, restricting their mechanical performance. To overcome this limitation, we developed a novel vacuum billet forging process for the fabrication of composite rolls.

Refining Stereotaxic Deep Brain Stimulation Surgery Procedures for Parkinson Disease in Pursuit of Zero Pneumocephalus: 2-Dimensional Operative Video.

Background And Objectives: Deep brain stimulation (DBS) is a well-established intervention for alleviating both motor and nonmotor symptoms of Parkinson disease. However, a common complication of stereotaxic DBS surgery is pneumocephalus, which can compromise electrode accuracy, complicate postoperative assessments, and negatively affect the long-term outcomes of DBS surgery. This report proposes a comprehensive and robust set of recommendations aimed at optimizing DBS surgical protocols to achieve zero pneumocephalus outcomes.

An evaluation framework for clinical use of large language models in patient interaction tasks.

The integration of large language models (LLMs) into clinical diagnostics has the potential to transform doctor-patient interactions. However, the readiness of these models for real-world clinical application remains inadequately tested. This paper introduces the Conversational Reasoning Assessment Framework for Testing in Medicine (CRAFT-MD) approach for evaluating clinical LLMs.

Clonal GZMKCD8 T cells are identified as a hallmark of the pathogenesis of cGVHD-induced bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation.

Background: Bronchiolitis obliterans syndrome (BOS) is one of the most devastating outcomes of chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This remains an area of unmet clinical need for optimal therapy for BOS patients partly due to the limited understanding of pathogenic mechanisms.

Methods: We collected blood samples from 22 patients with cGVHD and 11 patients without cGVHD following allo-HSCT.

Activation of persulfates on carbon nanotubes for water decontamination: Is the non-radical process consistently considered across different pH levels?

Carbon nanotubes-driven persulfates oxidation processes (CNTs/PS) have been extensively studied for environmental remediation. Solution pH is one of the main factors affecting wastewater treatment, but it is often overlooked. Herein, we report the effect laws of pH on the mechanism of peroxymonosulfate (PMS) or peroxydisulfate (PDS) activation by CNTs.

CLK1 Activates YAP to Promote Intrahepatic Cholangiocarcinogenesis.

Cdc2-like kinase 1 (CLK1) has dual-specificity kinase ability to phosphorylate tyrosine and serine/threonine protein residues. CLK1 regulates many physiological processes and has been shown to contribute to multiple types of cancer. Here, we investigated the functional role of CLK1 during intrahepatic cholangiocarcinoma (ICC) development.

Self-improving generative foundation model for synthetic medical image generation and clinical applications.

In many clinical and research settings, the scarcity of high-quality medical imaging datasets has hampered the potential of artificial intelligence (AI) clinical applications. This issue is particularly pronounced in less common conditions, underrepresented populations and emerging imaging modalities, where the availability of diverse and comprehensive datasets is often inadequate. To address this challenge, we introduce a unified medical image-text generative model called MINIM that is capable of synthesizing medical images of various organs across various imaging modalities based on textual instructions.

Recent progress and perspectives of advanced Ni-based cathodes for aqueous alkaline Zn batteries.

Rechargeable aqueous alkaline Zn-Ni batteries (AZNBs) are considered a potential contender for energy storage fields and portable devices due to their inherent safety, high output voltage, high theoretical capacity and environmental friendliness. Despite the facilitated development of AZNBs by many investigations, its practical application is still restricted by inadequate energy density, sluggish kinetics, and poor stability. Therefore, Ni-based cathodes with boosted redox chemistry and enhanced structural integrity is essential for the high-performance AZNBs.

Utilizing nontargeted metabolomics integrated with quality component quantitation via differential analysis to reveal the taste differences between and metabolite characteristics of hawk black tea and hawk white tea.

This study conducted a comprehensive analysis of the differences in the taste characteristics of hawk black tea and hawk white tea, exploring the intrinsic relationship between nonvolatile metabolites and these taste characteristics. The results revealed significant differences in taste properties of the two types of hawk tea. Hawk black tea mainly exhibits a fresh, sweet, and sweet aftertaste quality, whereas hawk white tea offers a mellow and pure taste.

GPRC5A promotes lung colonization of esophageal squamous cell carcinoma.

Emerging evidence suggests that cancer cells may disseminate early, prior to the formation of traditional macro-metastases. However, the mechanisms underlying the seeding and transition of early disseminated cancer cells (DCCs) into metastatic tumors remain poorly understood. Through single-cell RNA sequencing, we show that early lung DCCs from esophageal squamous cell carcinoma (ESCC) exhibit a trophoblast-like 'tumor implantation' phenotype, which enhances their dissemination and supports metastatic growth.

Comparisons between Caucasian-validated and Chinese-validated photo-numeric scales for assessing facial wrinkles.

Skin ageing results in wrinkling. In this study, we discuss four types of facial wrinkles: Crow's Feet wrinkles, forehead wrinkles, glabellar frown wrinkles, and nasolabial folds. These four phenotypes can be assessed either with a photo-numeric scale developed and validated on Caucasian skin (i.

Metformin inhibits migration and epithelial-to-mesenchymal transition in non-small cell lung cancer cells through AMPK-mediated GDF15 induction.

The growth differentiation factor 15 (GDF15) may serve as a biomarker of metformin, which mediates the bodyweight lowering effect of metformin. However, whether GDF15 also serves as a molecular target of metformin to inhibit carcinogenesis remains largely unknown. This study examined the role and molecular mechanisms of GDF15 in the anticancer effects of metformin in non-small cell lung cancer (NSCLC) cells, which has never been reported before.

M13mp18 nanoscaffold-based strip sensor for detecting influenza A virus (H1N1).

We report the development of an amplification-free nucleic acid assay using lateral flow test strips. M13mp18 nanoscaffold signal amplification permitted the visual detection of H1N1 RNA in 20 min. M13mp18 nanoscaffold supported a set of backbone, variable, detection, and modified oligonucleotides.

An explainable longitudinal multi-modal fusion model for predicting neoadjuvant therapy response in women with breast cancer.

Multi-modal image analysis using deep learning (DL) lays the foundation for neoadjuvant treatment (NAT) response monitoring. However, existing methods prioritize extracting multi-modal features to enhance predictive performance, with limited consideration on real-world clinical applicability, particularly in longitudinal NAT scenarios with multi-modal data. Here, we propose the Multi-modal Response Prediction (MRP) system, designed to mimic real-world physician assessments of NAT responses in breast cancer.

[Recurrence prediction of gastric cancer based on multi-resolution feature fusion and context information].

Pathological images of gastric cancer serve as the gold standard for diagnosing this malignancy. However, the recurrence prediction task often encounters challenges such as insignificant morphological features of the lesions, insufficient fusion of multi-resolution features, and inability to leverage contextual information effectively. To address these issues, a three-stage recurrence prediction method based on pathological images of gastric cancer is proposed.

The Risk of Exacerbation of Myasthenia Gravis After COVID-19 Omicron Infection.

Objective: The aim of this study is to ascertain whether COVID-19 Omicron infection is associated with exacerbations in these myasthenia gravis (MG) patients.

Result: In total, 289 MG patients (comprising 60% females, with an average age of 46 ± 15 years) were enrolled. A total of 80.

Nutritional status and neurodevelopmental levels in infants at high risk of cerebral palsy.

Importance: Nutrition is associated with neurodevelopment. Infants at high risk of cerebral palsy (CP) usually suffer from undernutrition, yet the relationship between nutritional status and neurodevelopmental levels is unclear.

Objective: To describe the nutritional status characteristics of infants at high risk of CP, and to explore the relationship between neurodevelopmental levels and nutritional status.

Association between the pre-transplantation serum ferritin level and outcomes of hematopoietic stem cell transplantation: A systematic review and meta-analysis.

Background: Iron overload, as indicated by evaluated serum ferritin (SF) level, occurs commonly in patients with hematological diseases. To evaluate the association between pre-transplant SF level and outcomes of hematopoietic stem cell transplantation (HSCT), we performed this systematic review and meta-analysis.

Methods: PubMed, Embase, Web of Science and the Cochrane Library electronic database were searched from inception to August 2023, and 56 studies with 14149 patients were found to be eligible.