Utility of Alpha-Fetoprotein and Ultrasound in the Diagnosis and Prognosis of Patients with Hepatocellular Liver Cancer.

Objective: To investigate the utility of alpha-fetoprotein (AFP) and ultrasound in the diagnosis and prognosis of patients with hepatocellular liver cancer (HCC).

Methods: Using retrospective convenience sampling, 401 patients with HCC who underwent transarterial chemoembolisation at the Department of Oncology of The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University between June 2015 and January 2020 were recruited and assigned to the case group.

Application of the Left Lateral Decubitus Position in Laparoscopic Right Posterior Lobectomy.

Objective: To investigate the value of the left lateral decubitus position in laparoscopic right posterior lobe tumor resection.

Patients And Methods: The clinical data of patients who underwent laparoscopic right posterior lobectomy from January 2020 to March 2023 were retrospectively collected and divided into group A (left lateral decubitus position group, n=30) and group B (conventional position group, n=35) according to different body positions. Intraoperative and postoperative data were collected and compared between the 2 groups.

Suppression of hepatocellular carcinoma progression by long noncoding RNA apolipoprotein C1 pseudogene via the regulation of the microRNA-106b-PTEN axis.

Background: Numerous researches have reported that long noncoding RNAs (lncRNAs) participate in tumor development and progression. LncRNA apolipoprotein C-I pseudogene 1 (), a pseudogene located in 19q13.2 between apolipoprotein C-I and apolipoprotein C-IV, is involved in a variety of diseases.

Simultaneously Improved Activity and Stability for Acidic Water Oxidation of IrRu Oxides by a Dual Role of Tungsten Doping.

Acidic oxygen evolution reaction (OER) remains a significant challenge due to the low activity and/or poor stability of the catalysts, even with state-of-the-art catalysts such as IrO and RuO. Herein, we propose a strategy to enhance both the catalytic activity and stability of IrRu oxides for acidic OER by doping non-noble metal W. The W-doped IrRuO (W-IrRuO) undergoes a process of W leaching and reconstruction during the OER, leading to a more uniform distribution of elements, while the electronegative nature of W influences the electronic structures of Ir and Ru in W-IrRuO.

Forsythiaside A exhibits anti-migration and anti-inflammation effects in rheumatoid arthritis in vitro model.

Background: Rheumatoid arthritis (RA) is a kind of systemic autoimmune disease, and the joint inflammation and cartilage destruction are the major features. Some traditional Chinese medicine have been discovered to exhibit regulatory roles in the treatment of RA. Forsythiaside A (FA) as an active ingredient isolated from forsythia suspensa has been discovered to participate into the regulation of some diseases through improving inflammation.

Construction of Durvalumab/carbon nanotube/PEI/aptamer-siRNA chimera for the immunotherapy of hepatocellular carcinoma.

Immunotherapy is the most promising treatment for hepatocellular carcinoma (HCC). However, the immunosuppressive microenvironment and necrosis limit its therapeutic effectiveness. Carbon nanotubes (CNTs) have good tissue permeability and can penetrate tumor necrosis area.

Construction of Durvalumab/carbon nanotube/PEI/aptamer-siRNA chimera for the immunotherapy of hepatocellular carcinoma.

Immunotherapy is the most promising treatment for hepatocellular carcinoma (HCC). However, the immunosuppressive microenvironment and necrosis limit its therapeutic effectiveness. Carbon nanotubes (CNTs) have good tissue permeability and can penetrate tumor necrosis area.

Boosting Charge Transport in BiVO Photoanode for Solar Water Oxidation.

The ability to regulate charge separation is pivotal for obtaining high efficiency of any photoelectrode used for solar fuel production. Vacancy engineering for metal oxide semiconductor photoelectrode is a major strategy but has faced a formidable challenge in bulk charge transport because of the elusive charge self-trapping site. In this work, a new deep eutectic solvent to engineer bismuth vacancies (Bi ) of BiVO photoanode is reported; the novel Bi can remarkably increase the charge diffusion coefficient by 5.

The expression of long non-coding RNA LINC01279 in gastric adenocarcinoma and its clinical significance.

Objective: To investigate the expression of long non-coding RNA LINC01279 in gastric cancer and its relationship with the clinicopathological features and prognosis of gastric cancer patients.

Methods: Serum, gastric cancer and adjacent tissue samples from 90-patients with gastric-cancer treated by surgery and serum samples from 90-healthy adults were collected. The expression level of LINC01279 was analyzed by RT-PCR.

The role of lncRNA ANRIL in the progression of hepatocellular carcinoma.

Objectives: The aim of the current study was to identify the long noncoding RNAs (lncRNAs) ANRIL function and molecular pathways underlying hepatocellular carcinoma progression.

Methods: ANRIL knockdown with specific siRNA, and transfected into HepG2 cells according to the protocol of Lipofectamine 2000. Cell proliferation, apoptosis, migration and metastasis were assessed with MTT assay, flow cytometry and wound healing assay, respectively.

Development and Characterization of a Novel Hydrogel for the Decontaminating of Radionuclide-Contaminated Skin Wounds.

Designing skin decontaminating materials with outstanding therapeutic effects, adhesiveness, and suitable mechanical property has great practical significance in radionuclide-contaminated skin wound healing. Here, a physically crosslinked hydrogel is constructed via hydrogen bonding of poly acrylamide, sodium alginate (SA), and the complexing agent diethylene triamine pentaacetic acid (DTPA). The physical and chemical properties of the poly(AAm-SA-DTPA) hydrogel (PASD) are detected according to established methods.

In Situ Induced Crystalline-Amorphous Heterophase Junction by K to Improve Photoelectrochemical Water Oxidation of BiVO.

Solar water splitting is one of the most efficient technologies to produce H, which is a clean and renewable energy carrier. Photoanodes for water oxidation play the determining roles in solar water splitting, while its photoelectrochemical (PEC) performance is severely limited by the hole injection efficiency at the interface of semiconductor/electrolyte. To address this problem, in this research, by employing BiVO as the model semiconductor for photoanodes, we develop a novel, facile, and efficient method, which simply applies K cations in the preparation process of BiVO photoanodes, to in situ induce a crystalline-amorphous heterophase junction by the formation of an amorphous BiVO layer (a-BiVO) on the surface of the crystalline BiVO (c-BiVO) film for PEC water oxidation.

A Cobalt@Cucurbit[5]uril Complex as a Highly Efficient Supramolecular Catalyst for Electrochemical and Photoelectrochemical Water Splitting.

A host-guest complex self-assembled through Co and cucurbit[5]uril (Co@CB[5]) is used as a supramolecular catalyst on the surface of metal oxides including porous indium tin oxide (ITO) and porous BiVO for efficient electrochemical and photoelectrochemical water oxidation. When immobilized on ITO, Co@CB[5] exhibited a turnover frequency (TOF) of 9.9 s at overpotential η=550 mV in a pH 9.

Electroless Plating of NiFeP Alloy on the Surface of Silicon Photoanode for Efficient Photoelectrochemical Water Oxidation.

-type silicon is a kind of semiconductor with a narrow band gap that has been reported as an outstanding light-harvesting material for photoelectrochemical (PEC) reactions. Decorating a thin catalyst layer on the -type silicon surface can provide a direct and effective route toward PEC water oxidation. However, most of catalyst immobilization methods for reported -type silicon photoanodes have been based on energetically demanding, time-consuming, and high-cost processes.

Electrochemical and photoelectrochemical water splitting with a CoO catalyst prepared by flame assisted deposition.

A novel flame-assisted deposition (FAD) method was used to generate and immobilize cobalt oxide (CoOx) on the surface of fluorine-doped tin oxide (FTO) and TiO2 modified hematite (TiO2/Fe2O3) for electrochemical and photoelectrochemical (PEC) water oxidation, respectively, with significant performance.

LicA induces autophagy through ULK1/Atg13 and ROS pathway in human hepatocellular carcinoma cells.

Chemotherapy is the best choice for the vast majority of hepatocellular carcinoma patients at late stage, but few effective chemotherapy drugs are available in clinic. Licochalcone A (LicA) is a new chemotherapy drug inducing apoptosis as Bcl-2 inhibitor, but few studies report on LicA‑induced autophagy. This study investigated the phenomenon and mechanisms of LicA-induced autophagy looking for a targeted combination drug.

High-intensity focused ultrasound therapy in combination with gemcitabine for unresectable pancreatic carcinoma.

Objective: To investigate the therapeutic effect and safety of high-intensity focused ultrasound (HIFU) therapy combined with gemcitabine in treating unresectable pancreatic carcinoma.

Methods: The 45 patients suffering from pancreatic carcinoma were randomized into two groups. The patients in the experimental group (n=23) received HIFU in combination with gemcitabine and those in the control group (n=22) received gemcitabine alone.

Preoperative ultrasound ablation for borderline resectable pancreatic cancer: A report of 30 cases.

Background And Objectives: Currently, extended resection and preoperative neoadjuvant chemotherapy are the two main modalities for improvement of the resection rate and R0 resection rate of borderline resectable pancreatic cancer. The past few years, however, have witnessed some progress in the treatment of unresectable pancreatic cancer with high intensity focused ultrasound (HIFU). The aim of this study is twofold: first, to evaluate the feasibility and safety of HIFU ablation as a preoperative adjuvant therapy for borderline resectable pancreatic cancer, and second, to conduct pathological analyses to verify the safety and effectiveness of HIFU treatment of pancreatic cancer.

Influence of specific blocking of the delta-like ligand 4/notch signal transduction pathway on the biological behavior of human umbilical vein endothelial cells.

The influence of specific blocking of the Delta-like ligand 4 (DLL4)/Notch signal transduction pathway on the biological behavior of human umbilical vein endothelial cells (HUVECs) has been studied. Recombinant adeno-associated virus (rAAV) vectors expressing an active small interfering RNA (siRNA) (vector 6) targeting the DLL4 (rAAV-DLL4-short hairpin RNA [shRNA]) was used to infect HUVECs. The same cell line infected with empty plasmid (rAAV-EGFP) was used as a control.

RNAi-mediated gene silencing of vascular endothelial growth factor inhibits growth of colorectal cancer.

Vascular endothelial growth factor (VEGF) is overexpressed in colorectal cancer (CRCs) cells and plays a critical role in angiopoiesis and cell proliferation, making it a potential target for cancer therapy. We developed a system that blocks VEGF in the human colorectal cancer cell line, HCT116, using RNA interference. By transfecting CRCs with the small interfering RNA (siRNA) that targets human VEGF, we were able to establish a stable clones in which VEGF expression was significantly downregulated (p<0.

[Study on the biomechanical behavior of human intestine].

To investigate the biomechanical behavior of human intestines. The tensile test human intestine was performed with the electronic tension machine in this paper. The results indicate that the exponential relationship for the stress-strain of the human intestine was obtained, and the exponential coefficient a of each segment of the intestine is almost the same although the constant C is different.

Expression of TGF-beta1 in smooth muscle cells regulates endothelial progenitor cells migration and differentiation.

Objective: Endothelial angiogenesis in the intima of the arterial wall is one of key events in the pathogenesis of arteriosclerosis. The molecular mechanisms by which transforming growth factor beta 1 (TGFbeta1) and endothelial progenitor cells may be responsible for angiogenesis of arteriosclerosis lesions are poorly understood.

Materials And Methods: Primary culture smooth muscle cells were transfected with pMAMneoTGFbeta1.

[Study on viscosity property of gastrointestinal mucus].

To probe further into the viscosity of gastrointestinal mucus, the samples of gastrointestinal mucus were taken from fifty normal people and were tested with Low-Shear 30 viscometer, and then the viscosity model was obtained. The results indicated that the apparent viscosity of large intestine mucus is greater than that of small intestine and stomach. The gastrointestinal mucus is a kind of non-Newtonian fluid when its apparent viscosity rapidly decreases with the increase of shear rate.