Publisher Correction: Vimentin knockout results in increased expression of sub-endothelial basement membrane components and carotid stiffness in mice.

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Vimentin knockout results in increased expression of sub-endothelial basement membrane components and carotid stiffness in mice.

Intermediate filaments are involved in stress-related cell mechanical properties and in plasticity via the regulation of focal adhesions (FAs) and the actomyosin network. We investigated whether vimentin regulates endothelial cells (ECs) and vascular smooth muscle cells (SMCs) and thereby influences vasomotor tone and arterial stiffness. Vimentin knockout mice (Vim) exhibited increased expression of laminin, fibronectin, perlecan, collagen IV and VE-cadherin as well as von Willebrand factor deposition in the subendothelial basement membrane.