Publications by authors named "Zhongzhong Lv"
J Cell Mol Med
December 2024
Article Synopsis
- The disruption of nerve tissues from spinal cord injury (SCI) can lead to further damage due to immune inflammatory responses involving Toll-like receptors, particularly TLR3, although its specific role in secondary neuronal injury is not fully clear.
- Researchers created a model using rat motor neurons to apply pressure, discovering that this pressure leads to neuronal damage, cell death, and decreased cell growth, all tied to increased TLR3 expression and its signaling molecules.
- Targeting TLR3 helped reduce injury and cell death in the neurons, promoting healthier cell processes like autophagy and reducing mitochondrial problems through specific signaling pathways (TLR3/IRF3 and TLR3/NF-κB).
