Molecular epidemiology and distribution of in human immunodeficiency-positive patients in China.

Objective: This study aims to inform the prevention and treatment of infections in China by analyzing the molecular epidemiology and distribution patterns of the pathogen.

Methods: A cross-sectional study was conducted involving a retrospective analysis of 64 clinical strains of isolated from January 2018 to April 2023 across various domestic regions. Patient information was collected from human immunodeficiency virus-positive individuals in multiple hospitals located in 19 cities within China's southeastern coastal and southwestern regions.

Polypod Carboxylic Acid-Rare Earth Complex with High Cyclic Stability for Nitrobenzene Compound Detection.

The 5',5''-bis(4-carboxyphenyl)-[1,1':3',1'':3'',1'''-quaterphenyl]-4,4'''-dicarboxylic (HL1) ligand has a large conjugated rigid planar structure and good absorption of ultraviolet radiation, which can provide effective "antenna effect". However, rare earth complexes using HL1 as the sole ligand have not been reported. In this paper, rare earth Eu was combined with HL1 ligand to produce organic rare earth composite L1-Eu by solvothermal synthesis method.

The research progress of rare earth agricultural light conversion film.

The light-converting agricultural film is a new high-end functional film that can convert ultraviolet light and yellow-green light, which is harmful or useless to plant photosynthesis, into red-orange light or blue-violet light required for photosynthesis. The potential advantages of light-converting agricultural film in efficiently utilizing solar energy and improving crop yield have attracted more and more attention from researchers and agricultural enterprises.The light-converting function is realized by adding a light-converting agent to the agricultural film.

The intellectual base and research fronts of IL-18: A bibliometric review of the literature from WoSCC (2012-2022).

Interleukin-18 (IL-18) is a vital pro-inflammatory cytokine crucial for immune regulation. Despite its significance, bibliometric analysis in this field is lacking. This study aims to quantitatively and qualitatively assess IL-18 research to construct its intellectual base and predict future hotspots.

Rational Design of Nitride Phosphor-In-Glass with Robust Stability and Photoluminescence Performance.

Phosphor-in-glass represents a promising avenue for merging the luminous efficiency of high-quality phosphor and the thermal stability of a glass matrix. Undoubtedly, the glass matrix system and its preparation are pivotal factors in achieving high stability and preserving the original performance of embedded phosphor particles. In contrast to the well-established commercial YAlO:Ce oxide phosphor, red nitride phosphor, which plays a critical role in high-quality lighting, exhibits greater structural instability during the high-temperature synthesis of inorganic glasses.

Advancements in elucidating the pathogenesis of actinic keratosis: present state and future prospects.

Solar keratosis, also known as actinic keratosis (AK), is becoming increasingly prevalent. It is a benign tumor that develops in the epidermis. Individuals with AK typically exhibit irregular, red, scaly bumps or patches as a result of prolonged exposure to UV rays.

Preparation of Novel C/N-Doped LaFeO Type Perovskite for Efficient Photocatalytic Degradation of Sodium Humate.

LaFeO chalcocite precursor was prepared by solid-phase milling method, and LaFeO-type chalcocite composite catalyst, referred to as LFCN catalyst, was synthesized by in situ doping of carbon and nitrogen (urea, melamine, dicyandiamide, and carbon powder), The catalytic performance of the catalysts was investigated by the different mass ratios of LaFeO chalcocite precursor and carbon and nitrogen (1:1, 1:2, and 2:1) and the degradation mechanism. Various characterization analyses, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Brunauer-Emmett-Teller (BET), showed that the doped composite LFCN catalysts exhibited a hemispherical network structure with a larger specific surface area than that of the pure phase LaFeO material. In addition, the LaFeO material adjusted the electronic structure of the original LaFeO chalcogenide material to a certain extent after in situ doping with organic C and N elements, which enhanced its lattice oxygen oxidation ability.

Deep learning-based multifeature integration robustly predicts central lymph node metastasis in papillary thyroid cancer.

Background: Few highly accurate tests can diagnose central lymph node metastasis (CLNM) of papillary thyroid cancer (PTC). Genetic sequencing of tumor tissue has allowed the targeting of certain genetic variants for personalized cancer therapy development.

Methods: This study included 488 patients diagnosed with PTC by ultrasound-guided fine-needle aspiration biopsy, collected clinicopathological data, analyzed the correlation between CLNM and clinicopathological features using univariate analysis and binary logistic regression, and constructed prediction models.

Identification of lncRNAs and Their Regulatory Relationships with mRNAs in Response to Infection of THP-1 Cells.

Aims: Cryptococcosis is an invasive fungal disease that is associated with an increasing prevalence along with a very high fatality and is primarily caused by Cryptococcus. However, its mechanism to cause pathogenicity is not yet completely understood. In this study, we aim to screen the lncRNA markers in human monocytic (THP-1) cells infected by () through high-throughput sequencing technology and to explore its effects on biological functions.

miR‑4792 regulates inflammatory responses in ‑infected microglia.

Investigating the factors that influence the inflammatory response of microglial cells is crucial for understanding the pathogenesis of cryptococcal meningitis (CM). MicroRNAs (miRNAs/miRs) play an important role in inducing host defenses and activating the immune response during microbial infection; however, the regulatory mechanisms of miRNAs in cryptococcal meningitis remain poorly defined. In a previous study, the authors assessed the miRNA profiles of THP‑1 (human acute monocytic leukemia cells) cells following infection.

The Generalized Entropy Ergodic Theorem for Nonhomogeneous Bifurcating Markov Chains Indexed by a Binary Tree.

In this paper, we study the generalized entropy ergodic theorem for nonhomogeneous bifurcating Markov chains indexed by a binary tree. Firstly, by constructing a class of random variables with a parameter and the mean value of one, we establish a strong limit theorem for delayed sums of the bivariate functions of such chains using the Borel-Cantelli lemma. Secondly, we prove the strong law of large numbers for the frequencies of occurrence of states of delayed sums and the generalized entropy ergodic theorem.

Sustained intrathecal delivery of amphotericin B using an injectable and biodegradable thermogel.

Cryptococcal meningitis is a fungal infectious disease with a poor prognosis and high mortality. Amphotericin B (AMB) is the first choice for the treatment of cryptococcal meninges. The blood-brain barrier (BBB) is the major barrier for the effective delivery of drugs to the brain.

MiR-30c-5p mediates inflammatory responses and promotes microglia survival by targeting eIF2α during Cryptococcus neoformans infection.

Cryptococcosis is a disease predominantly caused by Cryptococcus neoformans in China and C. neoformans is the main form that causes cryptococcal meningitis. In this study, we examined the influence of MiR-30c-5p during Cryptococcus neoformans infection.

TGF-β-mediated upregulation of brachyury contributes to constitutively up-regulated type I collagen expression in skin fibroblasts: possible role in systemic sclerosis.

Background: Previous reports have shown that epithelial-to-mesenchymal transition (EMT) indicates the importance of transforming growth factor-β (TGF-β) signalling in the pathogenesis of systemic sclerosis (SSc). However, the underlying molecular mechanisms of EMT are not fully understood.

Objectives: Brachyury, an evolutionarily conserved transcription factor, was recently identified as an important factor that promotes EMT in human carcinoma cell lines.

Transforming growth factor β-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.

Inhibition of transforming growth factor (TGF)-β1 signalling may be one of the most reliable approaches to treat skin fibrosis of scleroderma. Although there have been many basic researches of TGF-β blockade reagents, few of them were proved to have inhibitory effects on fibrosis both in vitro and in vivo. In this study, we randomly chose four commercially available low molecular weight compounds (Repsox, LY2109761, LY364947 and K02288) from TGF-β1 inhibitor library, and compared their antifibrotic effects in vitro and in vivo.

The expression of miR-124 increases in aged skin to cause cell senescence and it decreases in squamous cell carcinoma.

Skin senescence is induced by various factors including intrinsic aging and extrinsic aging. The current study compared the expression of microRNAs in young facial skin and senescent facial skin, and this study identified skin aging-related microRNAs. According to the results from a microRNA PCR Array, miR-124 was the microRNA that increased the most in senescent skin compared to young skin.

Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers.

Background: MicroRNA levels in sera or hair may potentially be useful biomarkers for various diseases. The diagnosis of nail diseases is sometimes difficult, and nail psoriasis without skin lesions is indistinguishable from nail changes caused by other diseases.

Objectives: We evaluated nail microRNA levels as biomarkers for the diagnosis of psoriasis patients.

Establishment and gene expression analysis of disease-derived induced pluripotent stem cells of scleroderma.

Background: We recently generated induced pluripotent stem cells (iPSCs) from cultured dermal fibroblasts of systemic sclerosis (SSc-iPSC) to study the disease mechanisms.

Objective: In the present study, we have performed gene expression analysis using cultured SSc dermal fibroblasts, SSc-iPSC, and fibroblasts re-differentiated from SSc-iPSC (SSc-iPSC-FB).

Methods: mRNA and protein levels of collagen and integrins were analyzed using PCR array, PCR, immunoblotting, and immunofluorescence.

Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization.

Long non-coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real-time PCR and in situ hybridization.

NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma.

Angiosarcoma is a malignant vascular tumor originating from endothelial cells of blood vessels or lymphatic vessels. The specific driver mutations in angiosarcoma remain unknown. In this study, we investigated this issue by transcriptome sequencing of patient-derived angiosarcoma cells (ISO-HAS), identifying a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined.

microRNA level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma.

Background: The diagnosis of dermatomyositis is sometimes difficult. We tried to evaluate the possibility that levels of Homo sapiens microRNA-214 (hsa-miR-214) in hair roots or hair shafts can be a useful marker of the disease.

Methods: A single hair root and five pieces of hair shafts were obtained from nine patients with dermatomyositis, 15 normal subjects, and 18 patients with scleroderma before treatment.