Myopia can impact an individual's quality of life and induce multiple complications. In this study, we randomly divided guinea pigs into the normal control (NC) group, the lens-induced myopia (LIM) group, the normal control plus l-arginine injection (l-Arg) group, and the normal control plus saline injection (NaCl) group. The animals in each group received the relevant treatments.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
November 2024
Purpose: This study aims to investigate the effect of quercetin (QUE) on scleral remodeling by inhibiting the PERK-EIF2α signaling pathway and to evaluate its potential role in slowing myopia.
Methods: Lens-induced myopia (LIM) guinea pigs were obtained and treated with QUE. After 4 and 6 weeks of treatments, ocular biological measurements were conducted.
This study aimed to establish a complete atlas of retinal cells in lens-induced myopia (LIM) and electroacupuncture (EA) intervention by single-cell RNA sequencing (scRNA-seq) and to explore the potential mechanism of EA in improving experimental myopia progression in guinea pigs. scRNA-seq is used to assess changes in individual cellular gene levels in the retina of LIM- and EA-treated guinea pigs. In addition, the role of EA in slowing myopia progression by improving retinal mitochondrial function is further investigated.
View Article and Find Full Text PDFMyopia represents a significant public health concern worldwide, particularly affecting the ocular health of children and adolescents. The escalating prevalence of myopia in recent years underscores its urgency as a health issue among this demographic. Research indicates a profound connection between the onset of myopia, inflammatory processes and fibrosis.
View Article and Find Full Text PDFCell Biochem Biophys
September 2024
In recent years, the prevalence of myopia has gradually increased, and it has become a significant global public health problem in the 21st century, posing a serious challenge to human eye health. Currently, it is confirmed that the development of myopia is attributed to the combined action of genes and environmental factors. Thus, elucidating the risk factors and pathogenesis of myopia is of great significance for the prevention and control of myopia.
View Article and Find Full Text PDFDysregulation of oxidative stress serves as a pivotal predisposing or exacerbating factor in the intricate development of numerous pathological processes and diseases. In recent years, substantial evidence has illuminated the crucial role of reactive oxygen species (ROS) in many fundamental cellular functions, including proliferation, inflammation, apoptosis, and gene expression. Notably, producing free radicals within ROS profoundly impacts a wide range of biomolecules, such as proteins and DNA, instigating cellular damage and impairing vital cellular functions.
View Article and Find Full Text PDFCurrently, researchers have mainly focused on the role of the tissues of the posterior segment of the eyes in the development of myopia. However, the ciliary body, an anterior ocular tissue that contracts to initiate the process of accommodation, may also play an important role in the progression of myopia due to the increased demand for near work. In the present study, we established a lens-induced myopia (LIM) animal model in guinea pigs and investigated the molecular changes in the ciliary body associated with the development of myopia based on RNA sequencing.
View Article and Find Full Text PDFBackground: An increasing number of systematic reviews (SRs) in the environmental field have been published in recent years as a result of the global concern about the health impacts of air pollution and temperature. However, no study has assessed and compared the methodological and reporting quality of SRs on the health effects of air pollutants and extreme temperatures. This study aims to assess and compare the methodological and reporting quality of SRs on the health effects of ambient air pollutants and extreme temperatures.
View Article and Find Full Text PDFPigment Cell Melanoma Res
March 2024
Melanoma is an aggressive malignant tumor with a poor prognosis. Vemurafenib (PLX4032, vem) is applied to specifically treat BRAF V600E-mutated melanoma patients. However, prolonged usage of vem makes patients resistant to the drug and finally leads to clinical failure.
View Article and Find Full Text PDFThe accurate estimation of a 3D human pose is of great importance in many fields, such as human-computer interaction, motion recognition and automatic driving. In view of the difficulty of obtaining 3D ground truth labels for a dataset of 3D pose estimation techniques, we take 2D images as the research object in this paper, and propose a self-supervised 3D pose estimation model called Pose ResNet. ResNet50 is used as the basic network for extract features.
View Article and Find Full Text PDFTo address the dangerous driving behaviors prevalent among current car drivers, it is necessary to provide real-time, accurate warning and correction of driver's driving behaviors in a small, movable, and enclosed space. In this paper, we propose a method for detecting dangerous behaviors based on frequency-modulated continuous-wave radar (mm-DSF). The highly packaged millimeter-wave radar chip has good in-vehicle emotion recognition capability.
View Article and Find Full Text PDFIn recent years, neural network-based soft sensor technology has been widely used in industrial production processes and has excellent optimization, monitoring, and quality prediction performance. This paper proposes a horizontal data augmentation strategy to provide highly available data for subsequent prediction models, called the combined autoencoder data augmentation (CADA) strategy. This paper has developed a CADA-based convolutional neural network (CADA-CNN) soft sensor model and applied it to the process of industrial debutanizer and industrial steam volume.
View Article and Find Full Text PDFThe positioning of indoor electronic devices is an essential part of human-computer interaction, and the accuracy of positioning affects the level of user experience. Most existing methods for RF-based device localization choose to ignore or remove the impact of multipath effects. However, exploiting the multipath effect caused by the complex indoor environment helps to improve the model's localization accuracy.
View Article and Find Full Text PDFPurpose: To investigate the intravitreal injection of conbercept as a treatment strategy for proliferative diabetic retinopathy (PDR) with or without center-involved diabetic macular edema (CI-DME) and evaluate its effect on the microvascular changes in the eyes.
Methods: In this prospective study, 43 patients including 29 cases (56 eyes) in CI-DME with PDR patients, and 14 cases (26 eyes) in the non-center involving diabetic macular edema (NCI-DME) with PDR patients were involved in this study. The best corrected visual acuity (BCVA), central retinal thickness (CRT), foveolar avascular zone (FAZ), and macular capillary vessel density (VD) of the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP) were assessed before and after conbercept treatments for 1, 3, or 6 months.
Background: There is no satisfactory answer on the specific biomarker that might be used in differentiating heart failure with reduced EF (HFrEF), allowing for inadequacy of N-terminal prohormone brain natriuretic peptide (NT-proBNP).
Objectives: We aim to evaluate the value of microRNA-208a in diagnosing HFrEF patients.
Methods: We included 120 HF patients and 60 healthy volunteers.
Sci Total Environ
August 2018
Air pollution has become a major concern in cities worldwide. The present study explores the spatial-temporal patterns of PM (particles with an aerodynamic diameters ≤2.5μm) and the variation in the attainment rate (the number of cities attaining the national PM standard each day) at different time-scales based on PM concentrations.
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