Impact of psychiatric disorders on the risk of glioma: Mendelian randomization and biological annotation.

Background: The conflicting results about the relationship between certain psychiatric disorders and glioma has been reported in previous studies. Moreover, little is known about the common pathogenic mechanism between psychiatric symptoms and glioma. This study aims to find out mental disorders related etiology of glioma and to interpret the underlying biological mechanisms.

A scoring system categorizing risk factors to evaluate the need for ventriculoperitoneal shunt in pediatric patients after brain tumor resection.

Objectives: To develop a scoring system based on independent predictors of the need for ventriculoperitoneal (VP) shunt after brain tumor resection in pediatric patients.

Methods: A total of 416 pediatric patients (≤ 14 years old) with brain tumors who underwent surgery were randomly assigned to the training (n = 333) and validation cohorts (n = 83). Based on the implementation of VP shunt, the training cohort was divided into the VP shunt group (n = 35) and the non-VP shunt group (n = 298).

A method for evaluating the safety of freeway tunnel sections based on driving comfort - a naturalistic driving study.

Objective: Driving comfort is crucial for tunnel safety because tunnel sections on freeways often introduce significant environmental changes that can compromise comfort and increase the risk of traffic accidents. This study aimed to quantitatively evaluate the driving comfort in tunnel sections and its implications for safety management.

Methods: Four indicators were used to assess the driving comfort: heart rate growth rate (Hrgr), skin conductance response (SCR), speed, and acceleration.

Blood Loss in Operation Is Independently Predictive of Postoperative Ventriculoperitoneal Shunt in Pediatric Patients With Posterior Fossa Tumors.

Background: To identify the risk factors for postoperative hydrocephalus and the need for ventriculoperitoneal (VP) shunt after posterior fossa tumor (PFT) resection in pediatric patients and establish a predictive model.

Methods: A total of 217 pediatric patients (≤14 years old) with PFTs who underwent tumor resection from November 2010 to December 2020 were divided into a VP shunt group (n = 29) and non-VP shunt group (n = 188). Univariate and multivariate logistic regression were performed.

Evaluating the effects of the route guidance variable message signs on driving behaviors-a driving simulation study.

Objective: Route guidance variable message signs (VMS) are widely applied in traffic incident management on highways by providing real-time spatiotemporal guidance information. The improper panel of route guidance VMS is likely to diminish the compliance with guidance and induce risky driving behaviors, disrupting the traffic flow or even causing crashes. This article aims to investigate the effects of route guidance VMS on driving behaviors in three aspects, vehicle operation, visual perception, and route choice.

Clinical features and outcomes of pediatric intracranial gliomas: results from single center's 226 cases and corroborated with SEER database.

Background: Pediatric gliomas are the most common central nervous system (CNS) tumors in children and adolescents and show different clinical and histopathological characteristics from the adult. The prognostic factors were poorly defined in pediatric intracranial gliomas.

Methods: We collected pediatric intracranial glioma cases in our institution between February 2011 and June 2022.

TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling.

In the glioblastoma (GBM) microenvironment, tumor-associated macrophages (TAMs) are prominent components and facilitate tumor growth. The exact molecular mechanisms underlying TAMs' function in promoting glioma stem cells (GSCs) maintenance and tumor growth remain largely unknown. We found a candidate molecule, transforming growth factor beta-induced (TGFBI), that was specifically expressed by TAMs and extremely low in GBM and GSC cells, and meanwhile closely related to glioma WHO grades and patient prognosis.

Driver operational level identification of driving risk and graded time-based alarm under near-crash conditions: A driving simulator study.

Rear-end collision and side collision are two types of accidents with the highest accident rate in the world. Numerous studies have focused on rear-end accident research, but only a few constructive countermeasures are put forward. Driving risk evolution at the driver operational level before an accident is critical to collision avoidance.

Investigating Causal Relationships Between Psychiatric Traits and Intracranial Aneurysms: A Bi-directional Two-Sample Mendelian Randomization Study.

Despite psychiatric traits were associated with intracranial aneurysms (IAs) in observational studies, their causal relationships remain largely undefined. We aimed to assess the causality between psychiatric traits and IAs. We firstly collected the genome-wide association statistics of IAs (sample size, = 79,429) and ten psychiatric traits from Europeans, including insomnia ( = 1,331,010), mood instability ( = 363,705), anxiety disorder ( = 83,566), major depressive disorder (MDD) ( = 480,359), subjective wellbeing ( = 388,538), attention deficit/hyperactivity disorder (ADHD) ( = 53,293), autism spectrum disorder (ASD) ( = 46,350), bipolar disorder (BIP) ( = 51,710), schizophrenia (SCZ) ( = 105,318), and neuroticism ( = 168,105).

Investigating the uniqueness of crash injury severity in freeway tunnels: A comparative study in Guizhou, China.

Introduction: With the rapid development of transportation infrastructures in precipitous areas, the mileage of freeway tunnels in China has been mounting during the past decade. Provided the semi-constrained space and the monotonous driving environment of freeway tunnels, safety concerns still remain. This study aims to investigate the uniqueness of the relationships between crash severity in freeway tunnels and various contributory factors.

Factors associated with consecutive and non-consecutive crashes on freeways: A two-level logistic modeling approach.

A consecutive crash consists of a primary crash and one or more secondary crashes that occur subsequently in a short period of time within a certain distance. It often affects a relatively large area of road space and the traffic disruption created can be difficult for traffic managers to control and resolve. This study identifies the factors delineating a primary crash that results in secondary crashes within a minute from a regular crash that does not result in any secondary crashes.

Driving risk assessment using driving behavior data under continuous tunnel environment.

Driving behavior is the key feature for determining the nature of traffic stream qualities and reflecting the risk of operating environments. However, evaluating the driving risk accurately and practically in continuous tunnels (tunnels with a space more than 250m and less than 1000m) still faces severe challenges due to the complex driving conditions. The objective of this study is to predict the driving risk indicators and determine different risk levels.