Young fibroblast-derived migrasomes alleviate keratinocyte senescence and enhance wound healing in aged skin.

Background: Alterations in intercellular communication driven by cellular senescence constitute an important factor in skin aging. Migrasome, a newly discovered vesicular organelle, efficiently participates in intercellular communication; however, the relationship between cellular senescence and migrasomes remains unreported.

Objective: This study aims to explore the possible relationship between cellular senescence and migrasomes formation, and investigate the effects of young fibroblast-derived migrasomes on senescent keratinocytes and wound healing in aged skin.

Sustained release of migrasomes from a methacrylate-oxidized hyaluronic acid/methacrylated gelatin composite hydrogel accelerates skin wound healing.

Migrasomes are newly discovered organelles with diverse physiological and pathological functions. Recent studies have shown that the local injection of fibroblast-derived migrasomes can accelerate skin wound healing; however, their effects are short-lived. To extend their therapeutic effects, we developed a skin-mimicking hydrogel (OHG) composed of methacrylate-oxidized hyaluronic acid (O-HA-MA) and methacrylated gelatin (GelMA).