Development and validation of a diagnostic nomogram model for osteoporosis in the elderly using 3D multi-echo Dixon sequence combined with magnetization transfer imaging.

Objective: To develop a novel combined nomogram based on 3D multi-echo Dixon (qDixon), magnetization transfer imaging (MTI) and clinical risk factors for the diagnosis of osteoporosis.

Materials And Methods: A total of 287 subjects who underwent MR examination with qDixon and MTI sequences participated in this study. These participants were randomly assigned to a training cohort and a validation cohort at a ratio of 7:3.

Lipocalin-2 and intestinal diseases.

Dysfunction of the intestinal barrier is a prevalent phenomenon observed across a spectrum of diseases, encompassing conditions such as mesenteric artery dissection, inflammatory bowel disease, cirrhosis, and sepsis. In these pathological states, the integrity of the intestinal barrier, which normally serves to regulate the selective passage of substances between the gut lumen and the bloodstream, becomes compromised. This compromised barrier function can lead to a range of adverse consequences, including increased permeability to harmful substances, the translocation of bacteria and their products into systemic circulation, and heightened inflammatory responses within the gut and beyond.

CYR61 is Involved in Neonatal Hypoxic-ischemic Brain Damage Via Modulating Astrocyte-mediated Neuroinflammation.

The activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in astrocytes has been found in the hypoxic-ischemic brain damage (HIBD) model. Cysteine rich angiogenic inducer 61 (CYR61) is secreted by reactive astrocytes. However, the effects of CYR61 on HIBD and its related mechanisms remain unclear.

Green Strong Cornstalk Rind-Based Cellulose-PVA Aerogel for Oil Adsorption and Thermal Insulation.

Cellulose-based aerogel has attracted considerable attention for its excellent adsorption capacity, biodegradability, and renewability. However, it is considered eco-unfriendly due to defibrillation of agriculture waste and requires harmful/expensive chemical agents. In this study, cornstalk rind-based aerogel was obtained via the following steps: green HO/HAc delignification of cornstalk rind to obtain cellulose fibers, binding with carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) and freeze-drying treatment, and hydrophobic modification with stearic acid.

Debris flow volume prediction model based on back propagation neural network optimized by improved whale optimization algorithm.

Debris flow is a sudden natural disaster in mountainous areas, which seriously threatens the lives and property of nearby residents. Therefore, it is necessary to predict the volume of debris flow accurately and reliably. However, the predictions of back propagation neural networks are unstable and inaccurate due to the limited dataset.

Circulating lipids, lipid-lowering drug targets, and breast cancer risk: Comprehensive evidence from Mendelian randomization and summary data-based Mendelian randomization.

Background: Breast cancer (BC) is the most common and fatal cancer among women, yet the causal relationship between circulating lipids, lipid-lowering drugs, and BC remains unclear.

Methods: Mendelian randomization (MR) and summary data-based MR (SMR) analysis are used to explore the causal relationship between plasma lipids, lipid-lowering drug targets, and BC.

Results: The result of MR suggested that per mg/dL higher levels of LDL-C (OR = 1.

Tunnel collapse risk assessment based on improved quantitative theory III and EW-AHP coupling weight.

It is a multi-criteria decision issue to conduct a risk assessment of the tunnel. In this paper, a tunnel collapse risk assessment model based on the improved theory of quantification III and the fuzzy comprehensive evaluation method is proposed. According to the geological conditions and the construction disturbance classification method, the evaluation factors are selected, and the tunnel collapse risk level is divided into 5 levels according to the principle of maximum membership degree.

[Allometry of scales in Chinese pangolins (Manis pentadactyla) and Malayan pangolins (Manis javanica) and application in judicial expertise].

Pangolins are unique mammals in that they possess scales that serve a protective biological function. As an important raw material of traditional medicine, illegal trades of these scales are frequent and difficult to investigate or prosecute. We used allometric models of dry weight of scales to compare 35 Chinese pangolins (Manis pentadactyla) and 119 Malayan pangolins (Manis javanica).