[KLF15/mTOR related proteins involved in effect of aerobic interval training on improving skeletal muscle lesions in rats with type 2 diabetes].

To investigate the effects of aerobic intermittent exercise on the expressions of KLF15/mTOR related proteins to improve skeletal muscle lesions in type 2 diabetes rats. The experimental model of type 2 diabetes rats was established by feeding high-fat diet for 4 weeks and intraperitoneal injection of streptozotocin (STZ). After modeling, rats were randomly divided into two groups: diabetes model group (DM), diabetes+exercise group (DE), and normal rats were set as control group (C), 10 rats in each group.

Cr cation-anchored carbon nanosheets: synthesis, paramagnetism and ferromagnetism.

Since the successfully synthesis of monolayer graphene, carbon-based materials have attracted wide and extensive attentions from researches. Due to the excellent transport capacity and conductivity, they are promising to be applied in electronic devices, even substituting the silicon-based electronic devices, optoelectronics and spintronics. Nevertheless, due to the non magnetic feature, many efforts have been devoted to endow carbon materials magnetism to apply them in the spintronic devices fabrication.

Tunable ferromagnetic ordering in phosphorus adsorbed ReS nanosheets.

Layered transition metal dichalcogenides (TMDs) are considered as promising materials for electronic, optoelectronic and spintronic devices due to their outstanding properties. Herein, based on rhenium disulfide (ReS) nanosheets, we realized the intrinsic room temperature ferromagnetism with the adsorption of P adatoms (P-ReS). Experiments indicate that the saturation magnetization (M ) can be tuned by the P ratios, where the maximum M can reach up to 0.

TNFRSF1B +676 T>G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy.

Background: The dysregulation of gene expression in the TNF-TNFR superfamily has been involved in various human cancers including non-small cell lung cancer (NSCLC). Furthermore, functional polymorphisms in TNF-α and TNFRSF1B genes that alter gene expression are likely to be associated with risk and clinical outcomes of cancers. However, few reported studies have investigated the association between potentially functional SNPs in both TNF-α and TNFRSF1B and prognosis of NSCLC patients treated with chemoradiotherapy.

Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review.

Lung cancer leads all other cancers in both incidence and mortality. Recent advances in underlying molecular pathogenesis have validated a panel of protein tyrosine kinases as new targets in lung cancer treatment. Insulin-like growth factor-1 receptor (IGF-1R) is an important tyrosine kinase receptor involved in cell proliferation, differentiation, metabolism, apoptosis, and angiogenesis.

Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer.

Purpose: Understanding how specific genetic variants modify drug action pathways may provide informative blueprints for individualized chemotherapy.

Methods: We applied a pathway-based approach to examine the impact of a comprehensive panel of genetic polymorphisms on clinical outcomes in 210 esophageal cancer patients.

Results: In the Cox proportional hazards model, MTHFR Glu429Ala variant genotypes were associated with significantly improved survival (hazard ratio [HR] = 0.