Huachansu Injection induces ferroptosis in multiple myeloma through NRF2/HO-1 signaling pathway.

Ethnopharmacological Relevance: Multiple myeloma (MM) is a common hematologic malignancy. Huachansu (HCS) is extracted from the skin of Bufo bufo gargarizans, known for its well-established and multi-target anti-tumor effect. It has been reported to be effective in treating patients with multiple myeloma but its underlying mechanism remains unclear.

Mutation of Encoding a C2H2 Zinc Finger Protein Induces ROS Accumulation and Accelerates Leaf Senescence in Rice.

Premature senescence of leaves causes a reduced yield and quality of rice by affecting plant growth and development. The regulatory mechanisms underlying early leaf senescence are still unclear. The () gene encodes a C2H2-type zinc finger protein that is localized to both the nucleus and cytoplasm.