Publications by authors named "Zhongwu Lin"

Microwave radiation, a prevalent environmental stressor, significantly impacts human health. Based on previous studies, we hypothesize that microwave-induced cognitive impairments and vulnerability in the hippocampal dentate gyrus (DG) region are due to abnormal synaptic plasticity regulated by both newborn and mature neurons derived from neural stem cells (NSCs). Epigenetics links external factors to organisms, offers insights into the health effects of environmental influences.

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The annual increase of microwave exposure in human environments continues to fuel debates regarding its potential health impacts. This study monitored the EEG and ECG responses of three Cynomolgus monkeys before and at 0, 3, 7, 14, and 30 days after exposure to 50 mW/cm² microwave radiation for 15 min. The findings revealed no significant differences in the power spectral densities (PSDs) of the whole brain, frontal, and temporal lobes across various frequency bands (δ, θ, α, β, low-γ, and high-γ) immediately and up to 30 days postexposure.

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Article Synopsis
  • Small nucleolar RNAs (snoRNAs) were once thought to mainly assist in modifying ribosomal RNA for ribosome production, but they also play roles in various biological processes beyond this traditional view.
  • Recent findings indicate that snoRNAs participate in the DNA damage response (DDR), a crucial mechanism for preserving genomic stability and preventing diseases.
  • The review discusses snoRNA biosynthesis, their regulatory mechanisms, their involvement in DDR, and their potential applications in diagnosing and treating diseases, highlighting their importance in genomic stability and pathology.
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Infrared small target detection is widely applied in military and civilian fields. Due to the small size of infrared targets, textural detail is missing. Common target detection methods extract semantic feature by narrowing down the feature map several times, which may lead to the small targets lost in deep layers and are not effective for infrared small target detection.

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Background: Current dosimeters cannot cope with the two tasks of medical rescue in the early stage of nuclear accident, the accurate determination of radiation exposure and the identification of patients with fatal radiation injury. As radiation can cause alterations in serum components, it is feasible to develop biomarkers for radiation injury from serum. This study aims to investigate whether serum BPIFA2 could be used as a potential biomarker of predicting fatal radiation injury in the early stage after nuclear accident.

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Background: Fast and reliable biomarkers are needed to distinguish whether individuals were exposed or not to radiation and assess radiation dose, and to predict the severity of radiation damage in a large-scale radiation accident. Serum amyloid A1 (SAA1) is a protein induced by multiple factors including inflammatory. Therefore, this study aimed at exploring the role of SAA1 in the radiation dose estimation and lethality prediction after radiation.

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In response to large-scale radiological incidents, rapid, accurate, and early triage biodosimeters are urgently required. In this study, we investigated candidate radiation-responsive biomarkers using proteomics approaches in mouse models. A total of 452 dysregulated proteins were identified in the serum samples of mice exposed to 0, 2, 5.

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