Radiol Case Rep
February 2025
Primary non-Hodgkin's lymphoma (NHL) occurring in the cauda equina region within the spinal canal is exceedingly rare. It is characterized by severe clinical symptoms, a high rate of misdiagnosis, rapid progression, poor prognosis, and significant metastasis potential. In this paper, we report 1 case of a 58-year-old female with primary NHL and another case of a 69-year-old male with secondary NHL.
View Article and Find Full Text PDFRecently, dual-metal catalysts have attracted much attention due to their abundant active sites and tunable chemical properties. On the other hand, metal borides have been widely applied in splitting the inert chemical bonds in small molecules (such as N) because of their excellent catalytic performances. As a combination of the above two systems, in this work, 11 kinds of transition metal atoms (TM = Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo, and W) were selected to embed in boron-doped graphene (BG) to construct 66 dual-metal-boron systems, and their performances toward the N reduction reaction (NRR) were examined using first-principles simulations.
View Article and Find Full Text PDFBackground: Bipolar disorder is a complex polygenic disorder that is characterized by recurrent episodes of depression and mania, the heterogeneity of which is likely complicated by epigenetic modifications that remain to be elucidated.
Methods: We performed transcriptomic analysis of peripheral blood RNA from monozygotic (MZ) twins discordant for bipolar disorder to identify disease-associated differentially expressed long noncoding RNAs (DE-lncRNAs), which were further validated in the PsychENCODE brain RNA-seq dataset. We then performed behavioral tests, electrophysiological assays, chromatin immunoprecipitation, and PCR to investigate the function of DE-lncRNAs in the mouse and cell models.
Front Microbiol
September 2024
Introduction: In mountainous tea plantations, which are the primary mode of tea cultivation in China, issues such as soil erosion and declining soil fertility are particularly severe. Although green manure cover is an effective agricultural measure for restoring soil fertility, its application in mountainous tea plantations has been relatively understudied.
Methods: This study investigated the effects of continuous green manure cover using the slope-protecting plant on tea plant growth and soil microbial community structure.
Accurate recognition of tool state is important for maximizing tool life. However, the tool sensor data collected in real-life scenarios has unbalanced characteristics. Additionally, although graph neural networks (GNNs) show excellent performance in feature extraction in the spatial dimension of data, it is difficult to extract features in the temporal dimension efficiently.
View Article and Find Full Text PDFGel permeation chromatography coupled with light scattering (GPC-LS) is among the most common methods for determining the molar masses of polymers. GPC-LS is widely used in polymer science research and has been adopted for many industrial applications owing to its high sensitivity, accuracy, and precision. The determination of polymer molar masses using GPC-LS is an important experimental component of the "Polymer Physics Experiments" course.
View Article and Find Full Text PDFBackground: Myeloid-derived suppressor cells (MDSCs) promote tumor growth, metastasis, and lead to immunotherapy resistance. Studies revealed that miRNAs are also expressed in MDSCs and promote the immunosuppressive function of MDSCs. Currently, few studies have been reported on inducible cellular microvesicle delivery of nucleic acid drugs targeting miRNA in MDSCs for the treatment of malignant tumors.
View Article and Find Full Text PDFArch Insect Biochem Physiol
May 2024
More and more evidence shows that small noncoding RNAs (ncRNAs) play diverse roles in development, stress response and other cellular processes, but functional study of intermediate-size ncRNAs is still rare. Here, the expression profile of 16 intermediate-size ncRNAs in ovary and testis of silkworm Bombyx mori were analyzed. Twelve ncRNAs, including 5 small nucleolar RNAs (snoRNAs) and 7 unclassified ncRNAs, accumulated more in the testis than in the ovary of silkworm, especially Bm-163, Bm-51 and Bm-68.
View Article and Find Full Text PDFIn symmetry-adapted perturbation theory (SAPT), accurate calculations on non-covalent interaction (NCI) for large complexes with more than 50 atoms are time-consuming using large basis sets. More efficient ones with smaller basis sets usually result in poor prediction in terms of dispersion and overall energies. In this study, we propose two composite methods with baseline calculated at SAPT2/aug-cc-pVDZ and SAPT2/aug-cc-pVTZ with dispersion term corrected at SAPT2+ level using bond functions and smaller basis set with MP2 corrections respectively.
View Article and Find Full Text PDFCell Stem Cell
June 2024
Glioblastoma (GBM) is the most common malignant primary brain tumor. Despite comprehensive treatment with traditional surgery, radiotherapy, and chemotherapy, the median survival rate is <14.6% and the 5-year survival rate is only 5%.
View Article and Find Full Text PDFHigh dynamic range 3D measurement technology, utilizing multiple exposures, is pivotal in industrial metrology. However, selecting the optimal exposure sequence to balance measurement efficiency and quality remains challenging. This study reinterprets this challenge as a Markov decision problem and presents an innovative exposure selection method rooted in deep reinforcement learning.
View Article and Find Full Text PDFMany types of cancer cells, including colorectal cancer cells (CRC), can simultaneously enhance glycolysis and repress the mitochondrial tricarboxylic acid (TCA) cycle, which is called the Warburg effect. However, the detailed mechanisms of abnormal activation of the glycolysis pathway in colorectal cancer are largely unknown. In this study, we reveal that the protein arginine methyltransferase 1 (PRMT1) promotes glycolysis, proliferation, and tumorigenesis in CRC cells.
View Article and Find Full Text PDFThe metastasis of non-small cell lung cancer (NSCLC) is the leading death cause of NSCLC patients, which requires new biomarkers for precise diagnosis and treatment. Circular RNAs (circRNAs), the novel noncoding RNA, participate in the progression of various cancers as microRNA or protein sponges. We revealed the mechanism by which circEPB41L2 (hsa_circ_0077837) blocks the aerobic glycolysis, progression and metastasis of NSCLC through modulating protein metabolism of PTBP1 by the E3 ubiquitin ligase TRIP12.
View Article and Find Full Text PDFTo address the complexities, inflexibility, and security concerns in traditional data sharing models of the Industrial Internet of Things (IIoT), we propose a blockchain-based data sharing and privacy protection (BBDSPP) scheme for IIoT. Initially, we characterize and assign values to attributes, and employ a weighted threshold secret sharing scheme to refine the data sharing approach. This enables flexible combinations of permissions, ensuring the adaptability of data sharing.
View Article and Find Full Text PDFBackground: Major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD) are complex genetic mental illnesses. Their non-Mendelian features, such as those observed in monozygotic twins discordant for SCZ or BPD, are likely complicated by environmental modifiers of genetic effects. 5-Hydroxymethylcytosine (5hmC) is an important epigenetic mark in gene regulation, and whether it is linked to genetic variants that contribute to non-Mendelian features remains largely unexplored.
View Article and Find Full Text PDFIn situ bioprinting has emerged as one of the most promising techniques for the sutureless tissue sealing of internal organs. However, most existing in situ bioprinting methods are limited by the complex and confined printing space inside the organs, harsh curing conditions for printable bioinks, and poor ability to suturelessly seal injured parts. The combination of in situ bioprinting and 4D printing is a promising technique for tissue repair.
View Article and Find Full Text PDFBiomass-coal blending combustion is an effective method for utilizing biomass; however, its pollutant emission requires attention. Herein, the effect of biomass-coal blending combustion on lead (Pb) transformation was explored. Combustion experiments were conducted in a fixed-bed reactor, using coal, corn stalk, rice stalk, bamboo flour and their mixtures as fuels, at 1000, 1100, 1200 and 1300 °C.
View Article and Find Full Text PDFA high recurrence rate of non-Hodgkin's lymphoma (NHL) following chimeric antigen receptor T (CAR T) cell treatment remains a bottleneck, and immunosuppressive tumor microenvironment (TME) compromising CAR T cell efficacy in NHL is the primary cause of relapse. Accordingly, modifying the structure of CAR T cells to attenuate the inhibitory effect of TME thus reducing recurrence rate is a valuable research topic. CD47 has been proved to be a promising therapeutic target and is crucial in regulating macrophage function.
View Article and Find Full Text PDFBackground: Blastocystis hominis (Bh) is zoonotic parasitic pathogen with a high prevalent globally, causing opportunistic infections and diarrhea disease. Human immunodeficiency virus (HIV) infection disrupts the immune system by depleting CD4 T lymphocyte (CD4 T) cell counts, thereby increasing Bh infection risk among persons living with HIV (PLWH). However, the precise association between Bh infection risk and HIV-related biological markers and treatment processes remains poorly understood.
View Article and Find Full Text PDFB-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematological disorder with a dismal prognosis. The dysregulation of histone acetylation is of great significance in the pathogenesis and progression of B-ALL. Regarded as a fundamental acetyltransferase gene, the role of HBO1 (lysine acetyltransferase 7/KAT7) in B-ALL has not been investigated.
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