Publications by authors named "Zhongwei Dong"
Article Synopsis
- The COVID-19 pandemic has resulted in increased cases of co-infection with SARS-CoV-2 and the Kaposi's sarcoma-associated herpesvirus (KSHV), leading to higher mortality rates due to the lack of targeted treatments.
- Cambogin, a natural product, has shown promise in reducing tumors associated with KSHV in mice, but its effects on SARS-CoV-2 were not fully understood until recent research.
- The study reveals that Cambogin targets 46 host genes affected by both viruses and effectively inhibits SARS-CoV-2 replication while also slowing the growth of KSHV-induced tumors, suggesting its potential as a treatment for patients co-infected with both viruses.
Unlabelled: TRIM32 is often aberrantly expressed in many types of cancers. Kaposi's sarcoma-associated herpesvirus (KSHV) is linked with several human malignancies, including Kaposi's sarcoma and primary effusion lymphomas (PELs). Increasing evidence has demonstrated the crucial role of KSHV lytic replication in viral tumorigenesis.
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- - The creation of broad-spectrum SARS-CoV-2 vaccines aims to alleviate global economic and public health challenges caused by the COVID-19 pandemic.
- - Combining conserved T-cell epitopes with spike antigens could improve immune responses, making COVID-19 vaccines more effective.
- - Research indicates that dual vaccination strategies can boost both systemic and mucosal immunity, enhancing protection against respiratory viruses.
Lactate is associated with the poor prognosis of many human malignancies. Cervical cancer, one of main causes of women mortality worldwide, is aggressive and absent of effective pharmacological treatment, and its underlying mechanisms of progression remain elusive. The regulation of β-catenin to fascin protrusion formation upon acidic lactate (Lactic acid [LA]) stimulation was evaluated through in β-catenin or fascin deficiency cell line models by immunofluorescence assays, and subcellular fractionation.
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