Publications by authors named "Zhongti Gao"
The 5-fluorouracil (5-FU)-based chemotherapy regimen is a primary strategy for treating pancreatic cancer (PC). However, challenges related to 5-FU resistance persist. Investigating the mechanisms of 5-FU resistance and identifying a clinically viable therapeutic strategy are crucial for improving the prognosis of PC.
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- Cadonilimab combined with FLOT chemotherapy shows potential as a neoadjuvant treatment for locally advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma, based on a multicenter trial in China.
- The trial involved treatment-naive patients, achieving a 100% R0 resection rate, a 21.1% pathological complete response rate, and a 44.7% major pathological response rate, indicating significant tumor reduction.
- The treatment had manageable side effects, with 31.6% of patients experiencing grade 3 adverse events, suggesting further research is warranted to explore its efficacy and safety.