Management of Apatinib-Related Adverse Events in Patients With Advanced Osteosarcoma From Four Prospective Trials: Chinese Sarcoma Study Group Experience.

Four prospective trials have reported apatinib-related efficacy in osteosarcoma, with a high response rate of 43.2%. Currently, Adverse Events (AEs) have increasingly gained attention, as treatment with multiple tyrosine kinase inhibitors (TKIs) is potentially lifelong.

[The effect of repeated bonding of octyl-a-cyanoacrylate adhesive on human tibia cortical bone].

During clinical operation, the repeated bonding of octyl-a-cyanoacrylate adhesive is necessary for satisfactory reduction and fixation. This is because the repeated bonding will change the morphologic characteristics of the bone surface in biomechanical study. The influence of repeated bonding of octyl-a-cyanoacrylate on fresh human tibia cortical bone was assessed in this experiment.

Octyl-a-cyanoacrylate adhesive in the treatment of tibial transverse fracture in rabbits.

Objective: To observe the effect of octyl-a-cyanoacrylate upon bone healing and its degradation in vitro after middle tibial transverse fracture in rabbitsì and to establish treatment of higher efficacy with the application of octyl-a-cyanoacrylate.

Methods: Middle tibial transverse fracture model of New Zealand rabbits was established. In the experimental group, internal fixation with 2 mm Kirschner wires was performed and the broken ends were fixed with octyl-a-cyanoacrylate.

Observation and establishment of an animal model of tractive spinal cord injury in rats.

Objective: To establish an animal model of tractive spinal cord injury in rats in order to investigate its pathophysiological changes and clinical significance.

Methods: T(12)-L(3) spines were tracted longitudinally with a special spinal retractor that was put on the proccessus transverses of T(12)-L(3) vertebrae of the rat after exposing T(13)-L(2) spinal cord via dual laminectomy. At the same tine, the spinal cord function was monitored by cortical somatosensory evoked potential (CSEP).

[Biomechanical study of medical hard tissue adhesive bonding butterfly fracture fragment in middle part of fresh human tibia].

A medical hard tissue adhesive, octyl-a-cyanoacrylate, was tested in 6 fresh human tibiae. A 90 degrees butter-fly fracture fragment was made in the middle part of tibia by bandsaw. The compressive stress, torsional stress and angular deflection were assessed before and after osteoectomy respectively.