Integrating microfluidics, hydrogels, and 3D bioprinting for personalized vessel-on-a-chip platforms.

Thrombosis, a major cause of morbidity and mortality worldwide, presents a complex challenge in cardiovascular medicine due to the intricacy of clotting mechanisms in living organisms. Traditional research approaches, including clinical studies and animal models, often yield conflicting results due to the inability to control variables in these complex systems, highlighting the need for more precise investigative tools. This review explores the evolution of thrombosis models, from conventional polydimethylsiloxane (PDMS)-based microfluidic devices to advanced hydrogel-based systems and cutting-edge 3D bioprinted vascular constructs.

Structural characteristics and nonvolatile metabolites of theabrownins and their impact on intestinal microbiota in high-fat-diet-fed mice.

This study prepared enzymatic theabrownins (TBs-e), alkaline theabrownins (TBs-a), and Pu-erh tea theabrownins (TBs-f), and investigated whether different preparation processes affected the structures, nonvolatile metabolites, and biofunctional activities of TBs. Structural characterization revealed that TBs were polymeric phenolic compounds rich in hydroxyl and carboxyl groups. Nontargeted metabolomics revealed that amino acids were the primary nonvolatile metabolites in TBs-e and TBs-a, accounting for over 70 % of the total nonvolatile content.

EIF3B correlates with advanced disease stages and poor prognosis, and it promotes proliferation and inhibits apoptosis in non-small cell lung cancer.

Background: Although up-regulation of EIF3B correlates with poor prognosis in carcinomas, the role of EIF3B in non-small cell lung cancer (NSCLC) is rarely known.

Objective: We aimed to investigate correlation of EIF3B with clinicopathological features and prognosis in NSCLC patients, and clarify its effect on cells proliferation and apoptosis.

Methods: Two hundred and eleven NSCLC patients underwent surgery were retrospectively reviewed.

Investigation of inner mechanism of anisotropic mechanical property of antler bone.

Bones have different functions and various applications depending on the roles they play in different mammal bodies. The internal relationships between the functions and microstructures of bones need further expounding to understand their specific mechanical properties. In this study, the relationships between the mechanical properties and microstructures of the compact bone of antler (called as antler bone for short) along its three different orientations are investigated.

Effects of Shape and Orientation of Pore Canals on Mechanical Behaviors of Lobster Cuticles.

The work is to investigate the relationships between the microstructures and mechanical behaviors of lobster cuticles and reveal the inner mechanisms of the anisotropic mechanical properties of the cuticles and give the helpful guidance for the design of high-performance man-made composites. First, the tensile mechanical properties of the longitudinal and transverse specimens of the cuticles of American lobsters were tested with a mechanical-testing instrument. It is was found that the fracture strength and elastic modulus of the longitudinal specimens are distinctly larger than those of the transverse specimens.