IL22 furthers malignant transformation of rat mesenchymal stem cells, possibly in association with IL22RA1/STAT3 signaling.

Mesenchymal stem cells (MSCs) hold great promise as potential therapies for tumors through the delivery of various anticancer agents. However, exogenous tissue‑derived MSCs, such as those of bone marrow, have exhibited a tendency for malignant transformation in the tumor microenvironment. This issue remains controversial and is poorly understood.

Mining Prognostic Significance of MEG3 in Human Breast Cancer Using Bioinformatics Analysis.

Background/aims: Maternally expressed gene 3 (MEG3) is an imprinted gene with maternal expression, which may function as a tumor suppressor by inhibiting angiogenesis. To identify the prognostic value of MEG3 in breast cancer, systematic analysis was performed in this study.

Methods: To evaluate gene alteration during breast carcinogenesis, we explored MEG3 expression using the Serial Analysis of Gene Expression Genie suite and Oncomine analysis.

Thermal behavior and kinetic study for co-pyrolysis of lignocellulosic biomass with polyethylene over Cobalt modified ZSM-5 catalyst by thermogravimetric analysis.

The thermal behavior and kinetic study of lignocellulosic biomass (rice straw (RS)) and linear low-density polyethylene (LLDPE) pyrolysis over modified ZSM-5 catalyst were investigated using thermo-gravimetric analysis (TGA). Cellulose and lignin were used as model compounds of biomass in order to investigate the reaction mechanism of lignocellulosic biomass and polyethylene co-pyrolysis. Results showed that RS&LLDPE co-pyrolysis was more complicated than that of the individual components.

Systematic analysis of gene expression alterations and clinical outcomes of STAT3 in cancer.

Accumulated studies have provided controversial evidences of prognostic value for signal transducer and activator of transcription proteins 3 (STAT3) in cancers. To address this inconsistency, we performed a systematic analysis to determine whether STAT3 can serve as a prognostic marker in human cancers. STAT3 expression was assessed using Oncomine analysis.