A novel BODIPY-derived colorimetric and ratiometric dual-mode fluorescent probe for highly sensitive and visual detection of sulfite in food and living organisms.

Sulfite, widely used as a food additive, performs indispensable functions in the field of food sterilization, bleaching, and antisepsis. However, the overuse of sulfite may destroy food nutrition and pose health risks to people. In this work, an innovative BODIPY-based fluorescent probe (BODIPY-DBC) was constructed for highly sensitive recognition of sulfite.

Carbazole-pyrimidine-based novel ratiometric fluorescent probe with large Stokes shift for detection of hydrazine in real environments and organisms.

Widespread application of hydrazine results in serious harm on the natural environments and human health because of its highly toxic, mutagenic, carcinogenic and teratogenic properties. Hence, it is very emergent to develop a convenient and efficient method for detection of hydrazine existed in real environments and living organisms. In this work, a novel ratiometric fluorescent probe PKZ-IN from the natural monoterpenoid 2-hydroxy-3-pinanone was designed and synthesized to detect trace hydrazine.

Synthesis of a new camphor-derived carboxylesterase-activated fluorescent probe for sensitive detection of dimethoate residues in agricultural products and its applications in biological systems.

In this paper, a camphor-derived enzyme activatable probe CPA was synthesized for detecting dimethoate pesticide. The ester bond of probe CPA could be selectively hydrolyzed and fragmented in the presence of carboxylesterase (CE), which caused a remarkably enhanced green fluorescence signal at 501 nm. Probe CPA could function as an effective fluorescent platform for the sequential detection of dimethoate due to the obvious inhibition effect of dimethoate on the activity of CE.

A novel fluorescent probe based on coumarin derivatives-grafted cellulose for specific detection of Fe and its application.

Fe is one of the most important ions for maintaining the normal growth of plants and animals. However, imbalance and accumulation of Fe can lead to serious damage to the environmental system. Hence, it is considerably crucial to monitor the concentration of Fe.

A novel fluorescent probe for fast detection of sulfur dioxide derivatives in water, soil, food samples and its applications in biological imaging.

Sulfur dioxide (SO) has a wide range of applications in food additives and industrial production, and it is one of the main substances that form acid rain, causing serious harm to ecosystems and human health. Hence, it is necessary to construct an effective tool to quickly and accurately detect SO derivatives in environmental, food, and biological samples. In this study, fluorescent probe NPMQ was built to detect SO derivatives from nopinone with the merits of superior water solubility, high sensitivity (12 nM), excellent specificity, large Stokes shift (180 nm), and rapid response time (within 5 s).

Development of a ratiometric fluorescent probe based on caffeic acid for hydrazine detection and its applications in water samples and living cells.

Hydrazine (NH) has been extensively utilized as a highly reactive chemical reagent. However, it is also seriously harmful to human beings and ecosystem. Thus, the development of an efficient detecting method for hydrazine is desirable.

A novel dialdehyde cellulose-based colorimetric and turn-on fluorescent probe for HS detection and its application in red wine.

Hydrogen sulfide (HS) is considered one of the most important gaseous transmitters in the metabolic system, and the abnormal concentration of HS is associated with a variety of diseases. Up to now, it is still a challenge to develop a portable assay for HS even though the research about the detection of HS is booming. Herein, a novel bifunctional dialdehyde-cellulose fluorescent probe DAC-DPD was prepared with high selectivity and sensitivity to HS with colorimetric and fluorescent "turn-on" characteristics, and the limit of detection (LOD) of DAC-DPD for HS was 0.

A highly effective curcumin-based fluorescent probe with single-wavelength excitation for simultaneous detection and bioimaging of Cys, Hcy and GSH.

Cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) act as significant roles in many physiological processes, and their abnormal proliferation will cause multiple diseases including Alzheimer's disease, Parkinson's disease, Cardiovascular disease, atherosclerosis, and soft tissue damage. However, It is challenging work to develop a efficient method for differentiating and detecting GSH, Cys and Hcy because of their significant similarity in structures and functions. In this work, a smart fluorescent probe FBCN based on curcumin was rationally devised and developed by etherifying the phenol hydroxyl group on FBC with NBD-Cl, which emitted strong green at 516 nm.

Rational design of a highly effective cellulose-based macromolecular fluorescent probe for real-time recognition of palladium ion in environmental samples and its applications in plant and zebrafish.

Palladium ion (Pd) plays an important role in our daily life, but poses a great threat to the environment and human health. Thus, it is desirable to exploit a rapid and sensitive approach to realize the detection of Pd. In this study, a cellulose acetate-based macromolecular fluorescent probe CA-NA-PA was successfully prepared for tracking amounts of Pd.

Phenanthroimidazole-based fluorescence probe for discriminative detecting of hydrazine and bisulfite and its applications in environmental samples.

Hydrazine (NH) and bisulfite (HSO) detection methods are urgently needed due to its harmful to the human health and environment safety. Herein, we reported a dual-response fluorescence probe EPC, which is capable of sequential detection of NH and HSO by two different fluorescence signals. The probe EPC itself showed yellow florescence.

A ratiometric fluorescent probe with a large Stokes shift for rapid and sensitive detection of Hg in environmental water samples and its applications in living cells and zebrafish.

Detection of highly toxic mercury ions (Hg) in actual environmental and biological samples is of significant importance for protecting environment and human health. In this paper, a new ratiometric fluorescent probe BTIA was designed and synthesized from 3-pinone based on Internal Charge Transfer (ICT) mechanism. BTIA could selectively recognize Hg over other competitive analytes with short reaction time (5 s), distinct ratiometric response, strong anti-interference ability, large Stokes shift (200 nm), and low detection limit (2.

In-situ evaluation the fluctuation of hypochlorous acid in acute liver injury mice models with a mitochondria-targeted NIR ratiometric fluorescent probe.

Acute liver injury (ALI) is a frequent and devastating liver disease that has been made more prevalent by the excessive use of chemicals, drugs, and alcohol in modern life. Hypochlorous acid (HClO), an important biomarker of oxidative stress originating mainly from the mitochondria, has been shown to be intimately connected to the development and course of ALI. Herein, a novel BODIPY-based NIR ratiometric fluorescent probe Mito-BS was constructed for the specific recognition of mitochondrial HClO.

Comprehensive investigations of four ratiometric fluorescent chemosensors based on 4-(1H-imidazol-2-yl)benzaldehyde skeleton for malononitrile detection.

Malononitrile is a very important chemical material and has wide application fields in production of medicines, pesticides, and extraction of gold. However, its nonnegligible hypertoxicity inspired researchers to develop more efficient analysis techniques to sensitively and selectively detect malononitrile. Nopinone derivatives initiated by our research group have been developed as a class of organic fluorescent chemosensors for identifying multiple analytes in recent years.

Study on the biodynamic characteristics and internal vibration behaviors of a seated human body under biomechanical characteristics.

To provide reference and theoretical guidance for establishing human body dynamics models and studying biomechanical vibration behavior, this study aimed to develop and verify a computational model of a three-dimensional seated human body with detailed anatomical structure under complex biomechanical characteristics to investigate dynamic characteristics and internal vibration behaviors of the human body. Fifty modes of a seated human body were extracted by modal method. The intervertebral disc and head motions under uniaxial white noise excitation (between 0 and 20 Hz at 1.

A novel colormetric and light-up fluorescent sensor from flavonol derivative grafted cellulose for rapid and sensitive detection of Hg and its applications in biological and environmental system.

Mercury ion (Hg) is one of harmful heavy metal ions that can accumulate inside the human organism and cause some health problems. In the article, a highly effective fluorescent probe named EC-T-PCBM was prepared by grafting flavonol derivatives onto ethyl cellulose for the specific recognition of Hg. EC-T-PCBM exhibited a remarkable fluorescence light-up response toward Hg with excellent sensitivity.

A novel dual-responsive colorimetric/fluorescent probe for the detection of NH and ClO and its application in environmental analysis and bioimaging.

Hydrazine (NH) and hypochlorite (ClO) are both reactive chemical substances extensively utilized across various industrial domains. Excessive hydrazine (NH) and hypochlorite (ClO) can pose significant risks to the environment, ecosystems, and human health. In order to assess and control the environmental hazard caused by NH and ClO, there is an imperative need for efficient methods capable of rapid and precise detection of these contaminants.

A ratiometric fluorescent probe with a large Stokes shift for the detection of Hg2+ and its applications in environmental sample and living system analysis.

Toxic mercury ions (Hg2+) can cause serious environmental pollution and accumulate in living organisms the food chain. Therefore, monitoring Hg2+ is crucial in ensuring the safety of ecosystems and organisms. In this work, a novel ratiometric fluorescent probe CMT (5-(4-(diphenylamino)phenyl)-1-(7-hydroxy-coumarin-3-yl)-4-pentene-1,3-dione) based on coumarin was developed for detecting Hg2+, which displayed obvious fluorescence changes, a low detection limit (2.

A novel ratiometric fluorescent sensor from modified coumarin-grafted cellulose for precise pH detection in strongly alkaline conditions.

Accurate and convenient monitoring of pH under extreme alkaline conditions is still a challenge. In this work, 4-(3-(7-hydroxy-2-oxo-2H-chromen-3-yl)-3-oxoprop-1-en-1-yl)benzamide (HCB), a coumarin derivative, was grafted onto dialdehyde cellulose (DAC) to obtain a sensor DAC-HCB, which exhibited a ratiometric fluorescent response to the pH of alkaline solutions, resulting in a significant fluorescent color change from yellow to blue (FI/FI) at pH 7.5-14.

An ultrasensitive cellulose-based fluorescent sensor for Al detection and its applications in plant tissue and food samples.

Fluorescent sensors available for metal ions detection have been extensively developed in recent years. However, developing an ultrasensitive fluorescent sensor for highly selectively detecting Al based on cellulose remains a challenge. In this study, an ethylcellulose-based flavonol fluorescent sensor named EC-BHA was synthesized by the esterification of ethylcellulose (EC) with a new flavonol derivative 4-(2-(2,3-bis(ethoxymeothy)phenyl)-3-hydroxy-4-oxo-4-H-chromen-7-yl) benzoic acid (BHA).

Rational design and comparison of three curcumin-based fluorescent probes for viscosity detection in living cells and zebrafish.

Viscosity is a crucial indicator of the cellular microenvironment, which can affect the normal level of cellular metabolism. Aberrant levels of viscosity can result in the emergence of a variety of physiological problems including diabetes, Parkinson's disease, inflammation, . Therefore, it is crucial to exploit effective assays that can detect viscosity levels in living cells and organisms.

A novel reversible fluorescent probe for sequential detection of Al and HPO based on caffeic acid and its applicability in cell imaging.

In this work, we focused on synthesizing a new fluorescent probe HBA based on caffeic acid for detecting Al/HPO by the mode of "off-on-off". HBA alone exhibited a weak fluorescence emission in aqueous solution. When Al was added into the HBA solution, a significant green fluorescence was found at 498 nm.

A highly specific chalcone derivative grafted ethylcellulose fluorescent probe for rapid and sensitive detection of Al in actual environmental and food samples.

Al is commonly utilized in daily life, however, the excessive accumulation of Al within organisms can result in severe health problems. Herein, a highly efficient fluorescent probe EC-HTC for Al was synthesized through chemical modification of ethyl cellulose. This probe exhibited a significant fluorescence enhancement response to Al, and it interestingly also possessed an obvious aggregation-induced emission (AIE) effect.

Fluorescent probe for sensitive discrimination of GSH and Hcy/Cys with single-wavelength excitation in biological systems via different emission.

Biothiols (GSH, Hcy, Cys) are important active sulfur substances in biological systems and widely participate in various physiological processes. The three kinds of biothiols have similar chemical structures, including the sulfhydryl group (-SH) and an amino group (-NH), so distinguishing two or more of them simultaneously is an important challenge. Herein, a nopinone-based fluorescent probe 3-(3-((4-nitrobenzoxadiazole vinyl) nopinyl difluoride (NF-NBD) was designed to distinguish GSH and Hcy/Cys by generating different fluorescence channels with a single excitation wavelength.

An efficient chitosan-naphthalimide fluorescent probe for simultaneous detection and adsorption of Hg and its application in seafood, water and soil environments.

As a virulent heavy metal ion, Hg will lead to a serious threat to ecosystem and human health. In this work, we reported a chitosan-naphthalimide fluorescent probe CS-NA-ITC for specific recognition and efficient adsorption of Hg. CS-NA-ITC showed no fluorescence in solution state, while the fluorescence intensity increased obviously at the presence of Hg, accompanied by the fluorescence color becomes from colorless to bright yellow.

A naphthalimide functionalized chitosan-based fluorescent probe for specific detection and efficient adsorption of Cu.

As one of the most abundant metal ions, Cu has turned into a great threat to human health and the natural environment due to its widely utilized in various industries. In this paper, a chitosan-based fluorescent probe CTS-NA-HY for detection and adsorption of Cu was rationally prepared. CTS-NA-HY exhibited a specific "turn off" fluorescence response to Cu and the fluorescence color changed from bright yellow to colorless.