Background: Although there is evidence of shared dysregulated pathways between diabetes and Parkinson's disease, epidemiologic research on an association between the two diseases has produced inconsistent results.
Objective: We aimed to assess whether known metabolomic markers of insulin resistance and diabetes are also associated with Parkinson's disease development.
Methods: We conducted a nested case-control study among Nurses' Health Study and Health Professionals Follow-up Study participants who had provided blood samples up to twenty years prior to Parkinson's diagnosis.